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Pharmaceutical composition for preventing and treating respiratory anaphylactic disease

A technology for allergic diseases and respiratory tract, applied in the direction of allergic diseases, drug combinations, respiratory system diseases, etc., to achieve the effect of improving the body's immunity, preventing respiratory allergic diseases, and strong proliferation

Inactive Publication Date: 2011-11-09
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As the respiratory mucous membrane inflammatory lesions caused by allergic reactions are caused by a variety of independent factors, most of the current chemically synthesized drugs are designed for one of the pathways, so often only partial curative effects can be obtained

Method used

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  • Pharmaceutical composition for preventing and treating respiratory anaphylactic disease
  • Pharmaceutical composition for preventing and treating respiratory anaphylactic disease
  • Pharmaceutical composition for preventing and treating respiratory anaphylactic disease

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1 Preparation of sensitized mouse spleen lymphocytes

[0030] Healthy male 6-week-old Balb / c mice were provided by the Department of Experimental Animals, Shanghai Medical College, Fudan University, SPF grade. On the first day, intraperitoneally inject 0.3 mL of OVA 100 μg mixed with aluminum hydroxide gel to make it sensitized. On the 8th and 15th days, the sensitization was strengthened twice with the same method. On days 22-28, 20 μL nasal drops of 4% 0VA normal saline solution were challenged every day. Twenty-eight days after modeling, the mice were sacrificed by neck dislocation. Spleen was taken aseptically, adipose tissue and connective tissue were removed, the tissue was cut into pieces with small scissors, and 2ml Hanks solution was added to make spleen lymphocyte suspension. Spleen lymphocytes were separated by density gradient centrifugation using mouse lymphocyte separation medium. Use a dropper to first suck out the upper layer to a distance of...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition containing traditional Chinese medicinal active components baicalin, icariin and astragaloside IV for preventing and treating respiratory anaphylactic disease. The invention determines the dose range of the traditional Chinese medicinal active components for inhibiting splenic lymphopoiesis of sensitized mice; and proven by further experiments in vitro, compared with single use of baicalin, icariin and astragaloside IV, the pharmaceutical composition provided by the invention has a stronger effect on inhibiting the splenic lymphopoiesis of sensitized mice, and a stronger effect on regulating Th cell differentiation and transformation of corresponding cell factors into the normalstate. The pharmaceutical composition provided by the invention can be used for further preparing a target organ protecting medicament, and preparing a monomer small compound medicament for improvingthe body immunity and preventing and treating respiratory anaphylactic disease.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a pharmaceutical composition for preventing and treating respiratory allergic diseases. In particular, it relates to a pharmaceutical composition for preventing and treating respiratory allergic diseases containing effective components of traditional Chinese medicines, baicalin, icariin and astragaloside. Background technique [0002] With the acceleration of the modern industrialization process, the improvement of people's living standards, and the change of the environment, the incidence of respiratory allergic diseases (allergic rhinitis, asthma) continues to increase. Allergic rhinitis and asthma are a kind of allergic diseases. Clinically, they are characterized by nasal itching, repeated sneezing, clear water nasal discharge, nasal congestion or dyspnea. They are extremely painful during attacks. Severe asthma can be life-threatening and seriously affect people’s qu...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P11/00A61P37/08
Inventor 张新民沈自尹弓唯一张卫东张素琴刘闰红顾一峰
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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