Composition for killing microbes

A technology for killing microorganisms and compositions, used in biocides, chemicals for biological control, animal repellents, etc. problems, to achieve the effect of overcoming dry skin and lack of water, easy to obtain raw materials, and good sterilization effect

Active Publication Date: 2011-11-23
JIANGZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above-mentioned invention, or containing a large amount of alcohol substances, is used for long-term disinfection of hands and skin, which may lead to dryness, dehydration, redness, and chapping of the skin, and puts forward higher requirements for the transportation and storage of disinfection products; or the bactericidal effect Generally, it takes a long time to achieve or cannot achieve the ability to quickly kill bacteria and viruses equivalent to the composition of the present invention; or the formula has too many ingredients, the preparation process is cumbersome, and the process is complicated

Method used

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  • Composition for killing microbes
  • Composition for killing microbes
  • Composition for killing microbes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prepare the disinfectant according to the following steps: Add 40L of hot purified water into a stainless steel bucket, weigh in 1kg of hypromellose and stir until transparent and clear. Add 200L of purified water into the preparation tank, add bronopol 0.3kg, 20% polyhexamethylene biguanide hydrochloride aqueous solution 15kg, 95% ethanol (volume ratio, converted to mass ratio is 92.3%, the same below) under stirring ) 440kg, isopropanol 39kg, glycerin 10kg, hypromellose solution, stop stirring after 5-10 minutes after adding, add purified water to 1000L scale, and continue stirring for 15 minutes. Subpackage after inspection and passing.

[0037] Among them, glycerin has the effect of emollient and skin care, and can slow down the irritation of alcohol solvents to the skin; hydroxypropyl methylcellulose can make the disinfectant form a film on the surface of the skin and articles, prolonging the antibacterial time; bronopol in this product used as a stabilizer.

[0...

Embodiment 2

[0042] The preparation method of the disinfectant composition is the same as that of Example 1, and the prepared disinfectant solution is absorbed in the non-woven fabric as a wet wipe additive solution to make sanitary wet wipes.

[0043] After testing, under the condition of 20°C±1°C, the sanitary wet wipes have an average killing rate of 100% on Escherichia coli and Staphylococcus aureus, and have an average killing rate of 100% on Staphylococcus aureus. The average killing rate of Monomonas is 100%, the average killing rate of hemolytic streptococcus is 99.94%, the average killing rate of Candida albicans is 99.91%, and the average killing rate of influenza virus is > 3.00, the inactivation logarithmic value of HIV virus > 3.00.

[0044] Hand disinfection field test: After 30 person-time repeated tests, the sanitation wipes act for 1 minute, and the average log value of killing natural bacteria on the surface of the hand is > 1.00.

[0045] Escherichia coli simulated on-s...

Embodiment 3

[0048] Prepare the product according to the following steps: add 40L of hot purified water into a stainless steel bucket, weigh in 0.5kg of hypromellose and stir until transparent and clear. Add 200L of purified water into the preparation tank, add bronopol 0.3kg, 20% polyhexamethylene biguanide hydrochloride aqueous solution 5kg, 95% ethanol 258kg, isopropanol 9kg, glycerin 12kg, hypromellose Add plain solution, stir for 5-10 minutes after adding, stop stirring, add purified water to 1000L mark, and continue stirring for 15 minutes. Subpackage after inspection and passing.

[0049] The prepared product can also be used as an additive liquid for wet wipes to be absorbed in non-woven fabrics to make wet wipes.

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Abstract

The invention relates to a composition for killing microbes, which is mainly used for hand antisepsis, surgical hand antisepsis and antisepsis of skins and mucosa and can be also used for killing the microbes at the surfaces of the articles; polyhexamthylene guanidine hydrochloride and ethanol are adopted as main active fungicide ingredients to be combined with a fungicide synergistic agent isopropanol, wherein the concentration of the ethanol is 79-467 g / L, the concentration of the polyhexamthylene guanidine hydrochloride is 0.01-15 g / L and the concentration of the isopropanol is 3-54 g / L; meanwhile, a moisturizer, a stabilizing agent, a thickening agent and other agents can be added as needed to obtain different dosage forms; and the composition has the advantages of good fungicide effect, high speed, no washing, high stability, reduction of skin irritation of the product and functions of protecting and moisturizing skins.

Description

technical field [0001] The present invention relates to a disposable, high-efficiency microorganism-killing composition for use on hands, skin, mucous membranes, and surfaces of articles including eating and drinking utensils. Background technique [0002] Due to the aggravation of global warming and environmental pollution, the mutation of pathogenic microorganisms is accelerating; the abuse of various antibiotics and antiviral drugs, viruses immune to antibiotics and antiviral drugs, and the emergence of highly pathogenic and highly infectious pathogenic microorganisms The emergence is also accelerating. To deal with and control the outbreak and prevalence of infectious diseases caused by pathogenic microorganisms, it is necessary to control the source of infection, cut off the transmission route and protect the susceptible population. Among them, cutting off the transmission route is an important safe and reliable means. [0003] Different from traditional antimicrobial p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A61K31/785A01N25/02A01P1/00A61P31/02A61P31/12A47K10/02A47K10/16
Inventor 钟虹光易敏之张文福陈芳夏春保卢建中李诒光马莉
Owner JIANGZHONG PHARMA
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