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Vitamin C injection and preparation method thereof

A technology of vitamins and injections, applied in the field of medicine, can solve problems such as inability to meet clinical needs, and achieve the effect of improving the stability of the main drug

Inactive Publication Date: 2011-11-23
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current specifications of injections cannot meet clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Vitamin C injection prescription: composed of 50% vitamin C, 0.1% sodium bisulfite, 0.1% cysteine ​​hydrochloride, 0.025% edetate disodium, 23.2% bicarbonate Sodium and 70% injection consists of water.

[0011] Preparation method of vitamin C injection: take water for injection with a weight-volume ratio of 70% of the total preparation amount to be saturated with CO2, add cysteine ​​hydrochloride, sodium bisulfite and disodium edetate dissolved in warm water, stir Make it dissolve, add vitamin C, slowly add sodium bicarbonate to the full amount under stirring, filter after dissolving, fill, and sterilize at 121°C for 8 minutes.

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PUM

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Abstract

The invention relates to a vitamin C injection and a preparation method thereof. An antioxidant, a metal chelating agent, and 20-26% of sodium bicarbonate for adjusting the pH to 5-7 are added to prevent preparation oxidation. The vitamin C injection prepared through adopting the method disclosed by the present invention has a good stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a vitamin C injection and a preparation method thereof. Background technique [0002] Vitamin C, also known as L-ascorbic acid, has been widely used since the 1920s when humans discovered that vitamin C could cure scurvy. Vitamin C can promote the formation of gamma globulin in the body, enhance the anti-infection ability; participate in the biological redox process in the body, which is beneficial to the synthesis of erythropoiesis, adrenal cortex hormone and neurotransmitter, etc., and participate in the detoxification process; protect other antioxidant activities in the body Substances against free radicals; can promote the excretion of heavy metal ions, and prevent the formation of carcinogens (nitrosamines); can improve myocardial metabolism, enhance contractility; can promote the formation of collagen fibers and tissue adhesives, and promote wound healing . Therefore, vita...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/375A61P3/02A61P31/00A61P7/00A61P9/00A61P39/02
Inventor 牛战旗牛锋张永强焦魁良孙晶波张甜
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD