Dentifrice composition

A technology of composition and dentifrice, which is applied in medical science, dentistry, oral care, etc., to achieve the effects of inhibiting inflammation, improving bitter taste, and excellent hyperesthesia inhibition effect

Active Publication Date: 2013-07-10
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology does not disclose the combined use of ascorbic acid ester or its salt, aluminum lactate and / or potassium nitrate, nor does it disclose the content ratio of the two components, and does not suggest the above-mentioned problem.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0074] Hereinafter, the present invention will be specifically described by showing experimental examples, examples, and comparative examples, but the present invention is not limited to the following examples. In addition, in the following examples, the compounding quantity is all mass %.

[0075] [Example, Comparative Example]

[0076] The dentifrice composition (toothpaste) of the composition shown in Table 1-Table 4 was prepared by the usual method, and the following experiment was performed and evaluated. The results are shown in Tables 1-4.

[0077] Ascorbic acid-2-phosphate magnesium (ascorbic acid PM, manufactured by Showa Denko Co., Ltd.), and sodium ascorbic acid-2-phosphate (Stei C-50, manufactured by DSM Nutrition Japan) were used for each component used in the preparation of these dentifrice compositions. , ascorbic acid-2-sulfate (manufactured by ITO Co., Ltd.), aluminum lactate (manufactured by Musashino Chemical Research Institute), potassium nitrate (manufac...

experiment example 1

[0078] [Experimental Example 1] Evaluation of improvement rate of bad breath due to periodontal disease

[0079] Evaluation of symptoms of hyperesthesia and subjective symptoms of periodontal disease (swelling and bleeding of gums) was performed with 10 volunteers with bad breath. First, the subject stopped oral hygiene for one day, collected 1 L of exhaled breath in a collection container made of fluororesin (Tedra Bag N type 1L size, manufactured by Sunplatec Co., Ltd.), and 10 perfumers evaluated the source according to the criteria described later. For the level of bad breath in periodontal disease, it was scored as S1.

[0080] Then, 1 g of the tested dentifrice was used once, twice a day, and after using it in the usual way (brushing teeth for 3 minutes with a toothbrush) for 1 month, the oral cleaning was also suspended for 1 day. 1 L of exhaled breath was collected in Bag N type 1 L size (manufactured by Sunplatec Co., Ltd.), and 10 perfumers evaluated the level of ba...

experiment example 2

[0095] [Experimental example 2] Evaluation of usability

[0096] Using each toothpaste, 10 people with symptoms of dentin hypersensitivity used 1 g of the tested dentifrice once, and used it for 3 minutes by the usual method (brushing teeth with a toothbrush for 3 minutes), and evaluated the toothpaste at this time by the following criteria Sensory sense of use such as bitterness, the average value of 10 people was calculated|required. This average value was judged according to the judgment criteria mentioned later.

[0097]

[0098] 4: Bitterness is not sensed at all, and the usability is very good.

[0099] 3: Almost no bitterness is sensed, and there is no problem with usability.

[0100] 2: Weak bitterness is sensed, and the usability is slightly problematic.

[0101] 1: Strong bitterness is sensed, and use cannot be tolerated.

[0102]

[0103] ◎: More than 3.5 points and less than 4 points

[0104] ○: More than 3 points, less than 3.5 points

[0105] △: More th...

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PUM

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Abstract

Disclosed is a dentifrice composition characterized by containing (A) at least one or more selected from ascorbic acid ester and salts thereof and (B) aluminum lactate and / or potassium nitrate, wherein the content ratio of ingredient (B) / ingredient (A) is 2-50 by mass ratio.

Description

technical field [0001] The present invention relates to a dentifrice composition which is excellent in suppressing hypersensitivity, exhibits a high preventive effect against bad breath and inflammation in the oral cavity derived from periodontal disease, and has a good plaque removal effect, and has a good usability, It is very effective in suppressing or preventing hyperesthesia symptoms, bad breath, inflammation, and other symptoms derived from periodontal disease. Background technique [0002] Periodontal disease is two major diseases in the oral cavity along with dental caries, and it is disease causing about half of the cause of loss of tooth. Most periodontal diseases are considered to be infectious diseases caused by bacteria mainly obligate anaerobic gram-negative bacilli, and as a result, connective tissue and alveolar bone are destroyed. The clinical manifestations of this process are inflammation, swelling, hemorrhage, pus discharge, bad breath, shrinkage of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/67A61K8/19A61K8/365A61Q11/00
CPCA61K8/365A61Q11/00A61K8/26A61K8/676A61K8/19
Inventor 寺林继乃近泽贵士天野步角谷治夫
Owner LION CORP
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