anti-muc1 antibody

An antibody and antigen technology, applied in the direction of antibodies, anti-tumor drugs, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, etc., can solve the problems of insufficient selectivity and unclear sugar chain specificity, etc. achieve less side effects
CN102264765AInactive Publication Date: 2011-11-30SHIONOGI & CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHIONOGI & CO LTD
Publication Date
2011-11-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The object of the present invention is to provide antibodies specific to cancer cells that do not bind to normal cells. The inventors of the present invention found that: using 2,3ST glycopeptides as antigens to immunize animals, the antibodies obtained unexpectedly, significantly and specifically recognize cancer-specific sugar chains, and then can recognize and kill cancer cells expressing such Cancer cells with specific sugar chains of MUC1, thereby solving the above-mentioned problems. The present invention provides an antibody, an antigen-binding fragment thereof, or a MUCl-binding molecule, which is, for example, 100-fold or more specific for a cancer-associated structure of MUCl as compared to a normal tissue-associated structure of MUCl.
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Description

technical field

[0001] The present invention relates to the technology in the field of antibodies. If further specified, it relates to an anti-Mucin-1 antibody and a cancer treatment technology using the antibody. Background technique

[0002] Mucin-1 (Mucin1, hereinafter also referred to as MUC1 in this specification), which is a kind of mucin, is a tumor-associated antigen and is a high-molecular-weight glycoprotein expressed in various adenocarcinomas. Studies have shown that: in this protein, the extracellular domain of the indispensable membrane glycoprotein is mainly composed of 20 amino acid core sequences rich in serine, threonine and proline (hereinafter also referred to as "Tn20-mer" in this specification). ; 30-90 tandem repeats of HGVTSAPDTRPAPGSTAPPA (SEQ ID NO: 1)). The repeat number of "Tn20-mer" expressed by individuals is genetically determined, resulting in size polymorphism.

[0003] Minimal sequence recognition for nearly all MUCl-reactive mAbs resides...

Claims

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