Application of lycium barbarum polysaccharides for preparing drugs for preventing and treating chronic stress and posttraumatic stress disorder

A post-traumatic stress and Lycium barbarum polysaccharide technology, which is applied in the field of Lycium barbarum polysaccharides in the preparation of drugs for post-traumatic stress disorder, can solve the problems of unseen prevention and treatment of stress, and achieve the prevention and treatment of stress disorder, Clear efficacy and high safety

Active Publication Date: 2012-11-21
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are good research results in the prevention and treatment of chronic stress and post-traumatic stress disorder, they are mainly in the form of compound preparations, and there are no ingredients that can be used for both medicine and food. Lycium barbarum and its extract - Lycium barbarum polysaccharide components are used alone to prevent and treatment stress reports

Method used

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  • Application of lycium barbarum polysaccharides for preparing drugs for preventing and treating chronic stress and posttraumatic stress disorder
  • Application of lycium barbarum polysaccharides for preparing drugs for preventing and treating chronic stress and posttraumatic stress disorder
  • Application of lycium barbarum polysaccharides for preparing drugs for preventing and treating chronic stress and posttraumatic stress disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Preparation of Lycium barbarum polysaccharide

[0037]Weigh 100 g of dried wolfberry pulp powder, reflux and degrease with petroleum ether (60-90°C) twice, each time for 1 h. Reflux extraction with 80% ethanol for 2 more times, 2 hours each time, to remove monosaccharides and oligosaccharides. Add 500ml of water to the dregs and extract twice in a 90°C water bath, and combine the second extracts. Concentrate under reduced pressure on a rotary thin film evaporator to 150 ml, add a small amount of activated carbon for decolorization, and filter. Add 5 times the amount of 95% ethanol to the filtrate, let it stand overnight, dissolve the precipitate after suction filtration with 100 ml of water and repeat alcohol precipitation once. The precipitate was washed several times with 95% ethanol, absolute ethanol, acetone, and ether, and dried at 60°C to obtain Lycium barbarum polysaccharide with a purity of ≥50%. Sieve and pack into capsules to obtain Lycium bar...

experiment example 1

[0058] Experimental example 1: Observation of Lycium barbarum polysaccharide on the general state, body weight and refusal reaction of PTSD rats induced by claustrophobic shock.

[0059] 72 SD rats, male, weighing 210±26g, were divided into experimental groups: control group, 18; claustrophobic electric shock stress group, 18; LBP low-dose prevention group, 18; LBP high-dose treatment group, 18;

[0060] The rats in the control group were fed with the same amount of normal saline every day, without stress;

[0061] In the LBP low-dose prevention group, 3 days before the electric shock, once a day, at a fixed time of 8:00 a.m., 10 mg / kg each time, for 3 consecutive days;

[0062] The LBP high-dose treatment group was 20 mg / kg per day, with 18 rats in each group, and the observation time points were 1w, 2w, and 4w after stress.

[0063] Rejection reaction: Grab the rat with a glove that the animal has never touched, and observe its reaction. Scoring criteria: 0: catches the ...

experiment example 2

[0068] Experimental example 2: Effects of Lycium barbarum polysaccharide on intrusive memory in post-traumatic stress disorder.

[0069] The freezing behavior of rats was used to detect. SD rats, male, body weight 210±26g; experimental grouping: control group, claustrophobic electric shock stress, LBP low-dose prevention group, LBP high-dose treatment group.

[0070] The rats in the control group were fed with the same amount of normal saline every day without stress. In the LBP low-dose prevention group, 3 days before the electric shock, once a day, at a fixed time of 8:00 in the morning, 10 mg / kg per animal, for 3 consecutive days; 20 mg / kg. There were 24 rats in each group, and the observation time points were 1w, 2w, and 4w after stress. Intrusive memory is mainly reflected by freezing behavior, and the freezing behavior measurement: Put the stressed rats into the reflex box, and measure the freezing behavior for 3 minutes. Freezing behavior is defined as a defensive...

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Abstract

The invention discloses application of lycium barbarum polysaccharides for preparing drugs for preventing and treating chronic stress and posttraumatic stress disorder. The application is characterized by comprising the following steps of: filling the extracted lycium barbarum polysaccharides with the purity of more than or equal to 50% in capsules or preparing the lycium barbarum polysaccharidesinto tablets, wherein each capsule contains 500 mg of the lycium barbarum polysaccharides, or each tablet contains 500 mg of the lycium barbarum polysaccharides; uniformly mixing the extracted lyciumbarbarum polysaccharides with the purity of more than or equal to 50% and corn startch; and filling the mixture into capsules or preparing the mixture into tablets, wherein each capsule contains 500 mg of the lycium barbarum polysaccharides and 100 mg of the corn starch, or each tablet contains 500 mg of the lycium barbarum polysaccharides and 100 mg of the corn starch. The application disclosed by the invention has the benefits that: the drugs are prescribed preparations composed of the lycium barbarum polysaccharides; the drugs have anti-stress effect and are capable of preventing and treating chronic stress and / or posttraumatic stress disorder and improving cognitive function; the pharmaceutical effect is clear; the safety is high; and the novel drug application selection is provided in clinical.

Description

technical field [0001] The invention relates to a new application of wolfberry extract, in particular to the application of wolfberry polysaccharide in the preparation of medicaments for post-traumatic stress disorder. Background technique [0002] Chronic stress disorder refers to the continuous emotional changes and psychological pressure experienced by individuals when they face long-term special environmental changes and cannot adjust and stabilize homeostasis. Its pathogenic mechanism is: the stressor stimulates the body to destabilize the state and the stress stimulus persists or repeatedly exists, then the effects of stress accumulate to form a steady-state strain load, and the stress-related neuroendocrine mediators and cytokines in the circulation and tissues continue to rise. High, and then developed into a steady-state strain overload. Due to the long-term action of a large number of neuroendocrine mediators and cytokines, various system organs, tissues and cells...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P25/22A61P25/28
Inventor 高洁杨策刘良明伍亚民
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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