The invention discloses premix-containing feed and application thereof. The premix is prepared from traditional Chinese medicinal materials and microecologic components, including 7-10 parts of astragalus roots, 5-8 parts of baikal skullcap roots, 3-5 parts of perilla seeds, 6-9 parts of cyrtomium rhizomes, 4-6 parts of pilose asiabell roots, 3-5 parts of coptis rhizomes, 3-5 parts of dried rehamnnia roots, 8-12 parts of malt, 4-6 parts of polygala roots, 4-6 parts of the rhizome of Chinese atractylode, 20-50 parts of garlic skin, 10-30 parts of aloe powder, 30-60 parts of zeolite, 3-5 parts of lactobacillus delbrueckii, 4-6 parts of selenium-enriched yeast, 2-4 parts of bacillus subtilis, 3-5 parts of bacteroides ruminocola and 2-4 parts of aspergillus oryzae, vitamin complex and trace mineral elements. The feed further comprises a feed main material prepared from yellow corn, yellow corn silage, sesame cake, hay meal, distiller grains and edible salt, and is mainly applied to feedingof beef cattle at the growing stage. The feed is environment-friendly feed, can be used for improving the yield, quality and flavor of beef cattle cultivation products, and can replace feed antibiotics and other drugs.