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Method for extracting magnolol from Magnolia officinalis tree leaves

A technology of magnolol and leaves, which is applied in the field of extracting active ingredients of plants, can solve the problems of unstable magnolol content, high production cost, and difficulty in factory production, so as to achieve simple and easy extraction process and avoid oxidative deterioration , the effect of reducing the impact

Inactive Publication Date: 2014-01-08
SHAANXI SHENLONG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few studies on extracting magnolol from Magnolia officinalis leaves. Even the published methods are only laboratory methods, which have the disadvantages of cumbersome extraction steps, complicated procedures, and high production costs. Moreover, the extracted Magnolia officinalis The content of phenol is unstable, and the extraction rate is also unstable, making it difficult to realize factory production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] Weigh 6.0kg of magnolia bark leaf powder, add 18kg of methanol to soak for 24h, filter with suction, repeat the leaching three times, concentrate the filtrate to a viscous extract, leaching with 1.3kg of saturated clarified lime water, stir for 1h, centrifuge , take the supernatant, repeat three times, acidify the supernatant with concentrated hydrochloric acid to pH = 3, stir for 30 minutes, centrifuge, mix the solid with 2-3 amounts of silica gel, add 1kg of 60-90℃ petroleum ether and heat to Slightly boil, keep warm for 10min, filter petroleum ether while hot, and use anhydrous Na 2 SO 4 Drying, taking the supernatant, concentrating, and cooling to obtain magnolol crystals, the extraction rate is 98.1%, and the content is 99.1%.

example 2

[0018] Accurately weigh 12.0kg of Magnolia officinalis leaf powder, add 32kg of methanol to soak for 24h, suction filter, and repeat the leaching three times, the filtrate is concentrated to a viscous extract, leaching with 3.2kg of saturated clarified lime water, stirring for 1h, centrifuging, and taking The supernatant was repeated three times, the supernatant was acidified with concentrated hydrochloric acid to pH = 2, stirred for 30 minutes, centrifuged, the solid was mixed with 2-3 amounts of silica gel, and 2.4kg of 60-90°C petroleum ether was added and heated to Slightly boil, keep warm for 10min, filter petroleum ether while hot, and use anhydrous Na 2 SO 4 Drying, taking the supernatant, concentrating, and cooling to obtain magnolol crystals, the extraction rate is 98.6%, and the content is 99.0%.

example 3

[0020] Accurately weigh 18.0kg of magnolia bark leaf powder, add 48kg of methanol to soak for 24h, filter with suction, repeat the leaching three times, concentrate the filtrate to a viscous extract, leaching with 4.2kg of saturated clarified lime water, stir for 1h, centrifuge , take the supernatant, repeat three times, acidify the supernatant with concentrated hydrochloric acid to pH = 3, stir for 30 minutes, centrifuge, mix the solid with 2-3 amounts of silica gel, add 3.6kg of 60-90℃ petroleum ether Heat to slightly boiling, keep warm for 10min, filter petroleum ether while hot, and use anhydrous Na 2 SO 4 Drying, taking the supernatant, concentrating, and cooling to obtain magnolol crystals, the extraction rate is 98.2%, and the content is 99.1%.

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PUM

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Abstract

The invention discloses a method for extracting magnolol from Magnolia officinalis tree leaves. The method comprises the following steps of: 1, immersing Magnolia officinalis tree leaf powder by methanol for 24 hours, filtering and repeatedly leaching for 3 times; and concentrating the filtering solution to obtain extract; 2, adding saturated clean lime water and agitating for 1 hour; centrifuging and repeating the step for three times; 3, acidifying liquid supernatant until the pH value is equal to 2-3, agitating for 30 min and centrifuging; mixing solid by silica gel and then heating the mixture to be slightly boiled by petroleum ether; preserving the heat for 10 min, filtering and drying the solution by anhydrous Na2SO4; and 4, concentrating the dried petroleum ether solution, cooling and crystallizing to obtain the magnolol product. The extracting processes of the method provided by the invention are all carried out at a normal temperature, the extracting rate can reach 98.1-98.6% and the content reaches 99.1%; the method has a simple and feasible process, and fewer steps, can obtain crystals with higher purity without complicated treatments, and is suitable for the industrial production in a large scale.

Description

technical field [0001] The invention relates to a method for extracting effective plant components, in particular to a method for extracting magnolol from magnolia bark leaves. Background technique [0002] Magnolia officinalis (Magnolia officinalis Rehd et Wils) or Magnolia biloba Rehded Wils Cheng (Magnolia biloba Rehded Wils Cheng) is an important traditional Chinese medicine. Magnolia officinalis contains many biologically active components, mainly containing magnolol and honokiol. Magnolol is mainly used as antibacterial and antifungal drugs in clinical practice. The content of magnolol in magnolobar bark is the highest, and magnolol It is basically extracted from the bark of Magnolia officinalis. Magnolia officinalis bark generally needs to grow for 15-20 years to meet the medicinal quality requirements, and the production cycle is very long. With the rapid development of social economy, the demand for magnolia is increasing, and the current magnolia resources can no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C39/21C07C37/84
Inventor 赖普辉田光辉廖德宏彭小涛刘存芳王敏孙志锋雷迎蒋翔
Owner SHAANXI SHENLONG PHARMA