Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma

A technology of glucocorticoid and composition, which is applied in the application field of glucocorticoid composition to treat severe and uncontrolled asthma, and can solve problems such as adverse side effects and hindering effective treatment of patients

Inactive Publication Date: 2012-01-04
ACTIVAERO GMBH RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, serious adverse side effects occur when such high doses of inhalable corticosteroids are administered, preventing effective treatment of these patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124]This example describes the therapy of the invention using a fluticasone composition and an AKITA device adapted to practice the invention. The study was conducted at the Davos Pulmonary Clinic. More than 100 patients with severe asthma who have been chronically maintained on oral corticosteroids are now treated with once-daily inhaled high-dose fluticasone (2000 microgram fluticasone filler dose) using the AKITA system. Patients are selected based on their need for OCS and based on poor symptom control. All patients had been previously treated with an inhaled corticosteroid / beta agonist combination using a metered dose inhaler and a dry powder inhaler and oral steroids at a mean of 22.9 mg / day prednisolone or equivalent. None of the patients had adequately controlled asthma symptoms and adequate lung function as measured by FEV1.

[0125] The treatment period was approximately 1 to 9 weeks, with an average of 3 weeks, inhaled fluticasone 2000 micrograms once daily in a...

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Abstract

A method for treatment of severe and uncontrollable asthma by providing means for delivery of high doses of a suitable inhalable corticosteroid directly to the small airways of the lower lungs with substantial decrease in need for simultaneous administration of oral corticosteroids and with a significant reduction in undesirable secondary side effects in an oropharyngeal area. The method utilizes devices allowing individualization of treatment parameters in asthmatic patients having compromised breathing pattern due to severe and uncontrollable asthma.

Description

Background of the invention [0001] The present invention relates to methods, devices and compositions for the treatment of severe and uncontrolled asthma. It provides a means of delivering high doses of suitable inhalable corticosteroids to the small and central airways of the lower lungs without requiring or significantly reducing the need for such simultaneous administration of oral corticosteroids. This approach significantly increases the delivery of aerosolized inhalable corticosteroids to the bronchi, bronchioles and alveoli of the central and lower peripheral lungs and reduces deposition of corticosteroids into the bronchi and trachea of ​​the upper lungs and the oropharyngeal region and thereby significantly reduces or completely Elimination of undesirable secondary (e.g., oropharyngeal) symptoms associated with administration of high-dose inhalable corticosteroids. The method utilizes a device that allows individualization of treatment parameters for asthmatic patien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/573
CPCA61K9/0078A61K31/573A61P11/00A61P11/06A61K9/0053A61K9/12
Inventor B.米林格G.索伊希T.霍夫曼P.克罗内贝格
Owner ACTIVAERO GMBH RES & DEV
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