Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma

Abstract

A method for treatment of severe and uncontrollable asthma by providing means for delivery of high doses of a suitable inhalable corticosteroid directly to the small airways of the lower lungs with substantial decrease in need for simultaneous administration of oral corticosteroids and with a significant reduction in undesirable secondary side effects in an oropharyngeal area. The method utilizes devices allowing individualization of treatment parameters in asthmatic patients having compromised breathing pattern due to severe and uncontrollable asthma.

Description

Background of the invention [0001] The present invention relates to methods, devices and compositions for the treatment of severe and uncontrolled asthma. It provides a means of delivering high doses of suitable inhalable corticosteroids to the small and central airways of the lower lungs without requiring or significantly reducing the need for such simultaneous administration of oral corticosteroids. This approach significantly increases the delivery of aerosolized inhalable corticosteroids to the bronchi, bronchioles and alveoli of the central and lower peripheral lungs and reduces deposition of corticosteroids into the bronchi and trachea of ​​the upper lungs and the oropharyngeal region and thereby significantly reduces or completely Elimination of undesirable secondary (e.g., oropharyngeal) symptoms associated with administration of high-dose inhalable corticosteroids. The method utilizes a device that allows individualization of treatment parameters for asthmatic patien...

AI Technical Summary

Problems solved by technology

However, serious adverse side effects occur when such high doses of inhalable corticosteroids are administered, preventing effective treatment of these patients