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Thermal responsive composition for treating bone diseases

A combination and sensitive technology, applied in bone diseases, drug combination, tissue regeneration, etc., can solve problems such as prolonging recovery time

Active Publication Date: 2012-01-11
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, regarding the repair of avascular necrosis of the femoral head, for example, in the tissue reconstruction of the hip joint, AVN (avascular necrosis, avascular necrosis) is more common in young adults. 75% of AVN patients can be cured. The current treatment method is core decompression, which involves drilling a hole from the side of the femoral head to the front end of the femoral head, or implanting autologous bone material full of blood vessels, so that blood can flow to the blood vessels and cannot stay. In order to accelerate bone regeneration, but it is necessary to obtain autologous bone full of blood vessels, so patients will suffer more injuries, and the recovery time will be prolonged later

Method used

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  • Thermal responsive composition for treating bone diseases
  • Thermal responsive composition for treating bone diseases
  • Thermal responsive composition for treating bone diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0046] The reactor is connected with a condenser, a heater and a temperature controller, and the condenser is wrapped with a heating tape, and the monomers precipitated through the condenser during the reaction process are melted back. The reactor is a 250ml columnar glass vessel (8cm×8cm×10cm). Mechanical agitation is used to carry out the polymerization reaction. Before the polymerization, the temperature is raised to 110° C. and nitrogen gas is passed for 30 minutes to remove impurities and moisture.

[0047] First, 10.04g mPEG (methoxy poly(ethylene glycol) (molecular weight: 550g / mole), 20g lactide (Lactide) and 5.64g glycolide (Glycolide) were sequentially added into the reactor, and the temperature was raised slowly until complete Dissolved. The temperature continued to rise to 160 ° C. At this time, 14.0 μl of the catalyst 2-ethyl-hexanoate (Stannous 2-ethyl-Hexanoate) was added, and the reaction was carried out for 8 hours (lactide and glycolide were polymerized into p...

Embodiment 2

[0054] The reactor is connected with a condenser, a heater and a temperature controller, and the condenser is wrapped with a heating tape, and the monomers precipitated through the condenser during the reaction process are melted back. The reactor is a 250ml columnar glass vessel (8cm×8cm×10cm). Mechanical agitation is used to carry out the polymerization reaction. Before the polymerization, the temperature is raised to 110° C. and nitrogen gas is passed for 30 minutes to remove impurities and moisture.

[0055] First, 11.18g mPEG (methoxy poly(ethylene glycol) (molecular weight: 550g / mole), 20g lactide (Lactide) and 8.57g valerolactone (Valerolactone) were successively added into the reactor, and the temperature was raised slowly until complete Dissolved. The temperature continued to rise to 160°C. At this time, 16.0 μl of the catalyst 2-ethyl-hexanoate (Stannous 2-ethyl-Hexanoate) was added and reacted for 8 hours (lactide and valerolactone were polymerized into poly(valerola...

Embodiment 3

[0061] The reactor is connected with a condenser, a heater and a temperature controller, and the condenser is wrapped with a heating tape, and the monomers precipitated through the condenser during the reaction process are melted back. The reactor is a 250ml columnar glass vessel (8cm×8cm×10cm). Mechanical agitation is used to carry out the polymerization reaction. Before the polymerization, the temperature is raised to 110° C. and nitrogen gas is passed for 30 minutes to remove impurities and moisture.

[0062] First, 12.01g PEG (poly(ethylene glycol)) (molecular weight 1000g / mole), 25.0g lactide (Lactide) and 5.68g glycolide (Glycolide) were sequentially added to the reactor, and the temperature was raised slowly until completely dissolved. The temperature continued to rise to 160°C. At this time, 17.07 μl of a catalyst, Stannous 2-ethyl-Hexanoate (Stannous 2-ethyl-Hexanoate), was added and reacted for 8 hours. After the reaction was completed, 4.81 g of succinic anhydride ...

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PUM

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Abstract

Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer, wherein the biodegradable copolymer is provided with an A high polymer and a B high polymer, and satisfies Formula (I) or Formula (II): A-B-BOX-B-A (Formula I) and B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II), wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2'-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.

Description

technical field [0001] The present invention relates to a temperature-sensitive composition, and in particular it relates to a temperature-sensitive composition for the treatment of bone diseases. Background technique [0002] Body tissues are often damaged due to disease. If the original function needs to be restored, unless the original tissue has a strong ability to heal and regenerate, in most cases it is necessary to use a substitute. The replacement produced by the method of tissue and organ transplantation (transplant) has many limitations due to the source and rejection. However, if biomedical materials can be used, that is, a synthetic or natural substrate (matrix) is used as a carrier, and tissue cells or stem cells are implanted (cell seeding) to move into the damaged part, then this biomedical material can become a tissue repair Regenerated bridges. [0003] According to medical statistics, in tissue repair, the repair of bone tissue accounts for about 30%. Th...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/52A61L27/54
CPCA61L2300/414A61L27/18A61L27/50A61L2430/02A61L27/58A61L27/54A61P19/00A61P19/08
Inventor 彭申桦沈欣欣杨良友谢孟佑李佩珊余惟琳林才佑赖伯亮孙瑞升张至宏林溢泓
Owner IND TECH RES INST
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