Chinese medicinal composition for treating chronic hepatitis B and preparation method and application thereof

A technology for chronic hepatitis B and composition, which is applied in the field of traditional Chinese medicine composition for treating chronic hepatitis B and its preparation field, can solve problems such as no curative effect, and achieve the effects of improving clinical symptoms, reasonable design and satisfactory curative effect.

Inactive Publication Date: 2012-01-18
朱方石
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Today, there are hundreds of liver-protecting and enzyme-lowering Chinese medicine preparations for the treatment of chronic hepatitis B, most of which have no particularly recognized curative effect

Method used

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  • Chinese medicinal composition for treating chronic hepatitis B and preparation method and application thereof
  • Chinese medicinal composition for treating chronic hepatitis B and preparation method and application thereof
  • Chinese medicinal composition for treating chronic hepatitis B and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of capsule

[0031] According to the raw material ratio in Table 1 and the conventional method of capsule dosage form, it is prepared into capsules, and the specific methods are as follows:

[0032] Take 10g of Solanum nigrum, 10g of Bupleurum radix, 20g of Hedyotis diffusa, 40g of Hedyotis diffusa, 10g of Ligustrum lucidum, 11g of jasmine jasmine, 3g of licorice and combine them with seven herbs, add water to decoct twice, and add water for the first time to equal the weight of the herbs. 8 times the amount, decocting for 1 hour, adding water for the second time is 6 times the weight of the medicinal materials, decocting for 1 hour, combining the decoction, and concentrating to 65 °C, the relative density is 1.15, adding ethanol to make the volume percentage of the alcohol content reach 75% , stirred, left to stand, filtered, the relative density of the filtrate was 1.20 when the filtrate was concentrated under reduced pressure to 65°C and...

Embodiment 2

[0033] Embodiment 2: the preparation of granule

[0034]According to the ratio of raw materials in Table 1 and the conventional method of granule dosage form, it is prepared into granules, and the specific method is as follows:

[0035] Take 15g Solanum nigrum, 8g Bupleurum bupleurum, 30g Hedyotis diffusa, 30g Weeping grass, 12g Ligustrum lucidum, 9g Jasmine jasmine, and 5g licorice. 10 times the amount, decocting for 1.5 hours, adding water for the second time is 8 times the weight of the medicinal materials, decocting for 1.5 hours, combining the decoctions, concentrating to 65 °C, the relative density is 1.20, adding ethanol to make the volume percentage of the alcohol content reach 80%, stirring, standing still, filtering, the relative density of the filtrate is 1.25 when the filtrate is concentrated under reduced pressure to 65°C and the ethanol is recovered to obtain a concentrated solution, which is spray-dried to obtain a dry extract powder. The spray-drying conditions...

Embodiment 3

[0036] Embodiment 3: the preparation of tablet

[0037] Prepare by the raw material proportioning of table 1 and tablet dosage form conventional method, be prepared into tablet, concrete method is as follows:

[0038] Take 20g of Solanum nigrum, 6g of Bupleurum radix, 40g of Hedyotis diffusa, 20g of Hedyotis diffusa, 14g of Ligustrum lucidum, 7g of Jasmine jasmine, and 7g of licorice. 12 times the amount, decoct for 2 hours, add water for the second time to 10 times the weight of the medicinal materials, decoct for 2 hours, combine the decoction, concentrate to 65 ° C, the relative density is 1.20, add ethanol to make the volume percentage of the alcohol content reach 85% , stir, stand still, filter, the relative density of the filtrate is 1.30 when the filtrate is concentrated under reduced pressure to 65°C and the ethanol is recovered to obtain a concentrated solution, which is prepared into an oral liquid by adding water and auxiliary materials to the concentrated solution,...

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Abstract

The invention discloses a Chinese medicinal composition for treating chronic hepatitis B and a preparation method and application thereof. The Chinese medicinal composition comprises the following raw materials: solanum nigrum, bupleurum, spreading hedyotis herb, stringy stonecrop herb, glossy privet fruit, fructus fardeniae praeparatus and liquoric root, and is prepared into various preparationsby performing water extraction and alcohol precipitation, performing spray drying and adding auxiliary materials. The Chinese medicinal composition has the effects of clearing heat, detoxifying, regulating the spleen and stomach, resisting viruses and protecting liver. The invention further discloses the application of the Chinese medicinal composition to a medicament for treating chronic hepatitis B.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating chronic hepatitis B, a preparation method and application thereof. Background technique [0002] According to the survey, the chronic hepatitis B virus infection in my country accounts for about 10% of the total population, among which there are about 15 million chronic hepatitis B patients, and more than 30% of the chronic hepatitis patients develop into liver cirrhosis. The main point of current treatment is to control the chronic injury of liver cells, protect the liver cells, resist hepatitis B virus infection and control the development of chronic liver disease to liver fibrosis. Although there are many medicines for the treatment of chronic hepatitis B both at home and abroad, western medicine nucleosides (acyclovir, lamivudine, adefovir dipivoxil, heptin) and interferon are effective a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P31/20A61P1/16
Inventor 朱方石金实徐婷婷吴晓燕
Owner 朱方石
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