Preparation method of ciprofloxacin and enrofloxacin residue freeze-dried powder standard sample in carp muscle

Abstract

The invention discloses a preparation method of a ciprofloxacin and enrofloxacin residue freeze-dried powder standard sample in carp muscle, which takes the carp as a research object to research a carp muscle material object standard sample containing ciprofloxacin and enrofloxacin of certain concentration in a breeding mode of adding target medicine. The key production control technology of the material object standard sample disclosed by the invention is mastered and comprises the control of content level, evenness, stability, constant value and the like, and the standard sample is produced and prepared in a standardization and scale mode. The standard sample is used for detection quality control and detection capability evaluation for residue of veterinary drug in animal-derived food and has an important significance on food safety detection.

Description

technical field [0001] The invention belongs to the technical field of animal food matrix standard substances for detection of veterinary drug residues, and in particular relates to a method for preparing standard samples of ciprofloxacin and enrofloxacin residual matrix freeze-dried powder in carp muscle. [0002] Reference material is a measurement standard with accurate value. It is used to study and evaluate measurement methods, ensure the consistency and comparability of measurement results, and ensure the differences between countries, departments, commodity exchanges or technical exchanges, and production process control. The comparability and consistency of analytical results between times is materially important. [0003] Reference Material (RM for short) includes pure chemical substances and physical standard samples with certain physical and chemical properties Background technique [0004] Ciprofloxacin and enrofloxacin are typical quinolones. Quinolones are a k...

AI Technical Summary

Problems solved by technology

At present, the standard substances used for the detection of quinolone drug residues are mainly various pure standard samples, and the quality control of the detection is mainly performed by adding various pure standard substances to the sample for detection and analysis. This analysis method cannot represent the target analyte. The state that actually exists in vivo, that is, it cannot represent the "internalized" state of the target analyte in the animal

The standard sample obtained in this way is not a real physical standard sample. Because the combination of the target object and the matrix is ​​not completely consistent with the real test sample, the results of extraction, purification, etc. are quite different from the daily analysis samples, thus affecting the accuracy of the results. Reliability and Validity

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