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Application of levo-camphor in preparation of drug for preventing and treating ischemic stroke

An ischemic stroke, drug technology, applied in the field of medicine

Active Publication Date: 2012-01-25
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report that camphor has other medicinal uses

Method used

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  • Application of levo-camphor in preparation of drug for preventing and treating ischemic stroke
  • Application of levo-camphor in preparation of drug for preventing and treating ischemic stroke
  • Application of levo-camphor in preparation of drug for preventing and treating ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] The preparation of embodiment 1 left-handed camphor dripping pills

[0140] Take 10g of left-handed camphor and add it to 10ml of ethanol to dissolve; add the mixture of polyethylene glycol-4000 20g and polyethylene glycol-6000 70g melted at 80°C to the medicine, mix well, and after the air bubbles are gone, draw the medicine solution to the appropriate Dropping speed drops into liquid paraffin and other coolants, let it stand for molding, take it out, and dry it. That is to make drop pills containing 10% L-camphor.

Embodiment 2

[0141] Example 2 Preparation of L-camphor Injection

[0142] Take 1g of left-handed camphor, dissolve it completely with 0.5ml of ethanol, add 8g of Tween-80 and mix well, dissolve 9g of sodium chloride in 500ml of water, mix well with the above liquid medicine, dilute to 1000ml, and fill it into an ampoule , drawing and sealing, autoclaving, made into 1mg·ml -1 Injection of L-camphor.

Embodiment 3

[0143] Example 3 Preparation of L-camphor Oral Liquid

[0144] Get 10g of left-handed camphor, 15g of Tween, 10g of sucrose, add water to 1000ml, be configured into a 1% aqueous solution, mix well, filter, put into a glass bottle and seal, press the cap, and sterilize at high temperature to obtain the oral liquid. 1ml contains about 10mg of L-camphor.

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Abstract

The invention discloses application of levo-camphor in preparation of a drug for preventing and treating ischemic stroke, relating to the field of medicines. The application of levo-camphor in preparation of the drug for preventing and treating ischemic stroke is characterized in that the drug is a composition composed of levo-camphor and pharmaceutically acceptable carriers; the use dosage of the levo-camphor is about 0.3-0.9 mg / kg for a human body; and the drug composition can be prepared into injections, dropping pills, tablets, hard capsules, soft capsules or oral liquid.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of L-camphor in the preparation of medicines for preventing and treating ischemic stroke. Background technique [0002] Ischemic stroke is a common and frequently-occurring disease with high mortality and disability rates, which seriously threatens human life and quality of life. These constitute a serious social problem. One of the pathological features of ischemic stroke is nerve dysfunction caused by nerve cell damage. Therefore, drugs that have a protective effect on ischemic nerve cells are effective drugs for ischemic stroke. See literature: Tuttolomondo A, Di Sciacca R, Di Raimondo D, Arnao V, Renda C, Pinto A, Licata G. Neuron protection as a therapeutic target in acute ischemic stroke. Curr Top Med Chem. 2009; 9 (14):1317-34). The literature Wu D. Neuroprotection in experimental stroke with targeted neurotrophins. NeuroRx. 2005; 2(1):120-8 proved that brain-derived neur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/125A61P9/10
Inventor 魏刚陈东风刘东辉周健洪邓汝东张琼丹
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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