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Preparation method of tetramine platinum chloride

A kind of technology of tetraammine platinum chloride and tetraammine chloride, which is applied in the field of preparation of platinum complex tetraammine platinum chloride

Inactive Publication Date: 2012-01-25
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006]This method is characterized by a high conversion rate, which can reach more than 95%. The disadvantage is that cisplatin is used as a reactant, which leads to an increase in cost and is not suitable for industrial production

Method used

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  • Preparation method of tetramine platinum chloride
  • Preparation method of tetramine platinum chloride
  • Preparation method of tetramine platinum chloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: take by weighing the 10g Magnus salt that purity is 96%, join in the round bottom flask, add the 30ml ammoniacal liquor that concentration is 24%, under normal pressure, boiling condition, reflux 8h, until green Magnus salt all disappears, obtains pale Yellow tetraammineplatinum chloride solution was distilled under reduced pressure to obtain 3.49 g of pale yellow to colorless tetraammineplatinum chloride solid.

[0021] The model is 353[M+H] + Electrospray mass spectrometer (ESI-MS) for elemental analysis: actual value N% 15.97, H% 3.50 Pt% 55.48; theoretical value N% 15.91, H% 3.41 Pt% 55.40.

Embodiment 2

[0022] Embodiment 2: take by weighing the 20g Magnus salt that purity is 98%, join in the round bottom flask, add the 70ml ammoniacal liquor that concentration is 26%, under normal pressure, boiling condition, reflux 7h, until green Magnus salt all disappears, obtains pale Yellow to colorless tetraammine platinum chloride solution was distilled under reduced pressure to obtain 7.13 g of light yellow to colorless tetraammine platinum chloride solid.

[0023] The model is 353[M+H] + Electrospray mass spectrometer (ESI-MS) was used for elemental analysis, the actual value N%15.60, H%3.45 Pt%55.41; theoretical value N%15.91, H%3.41 Pt%55.40.

Embodiment 3

[0024] Embodiment 3: take by weighing the 30g Magnus salt that purity is 99%, join in the round bottom flask, add the 120ml ammoniacal liquor that concentration is 28%, under normal pressure, boiling condition, reflux about 6h, until green Magnus salt all disappears, obtains Light yellow to colorless tetraammine platinum chloride solution, this solution was distilled under reduced pressure to obtain 10.45 g of light yellow to colorless tetraammine platinum chloride solid.

[0025] The model is 353[M+H] + Electrospray mass spectrometer (ESI-MS) for elemental analysis: actual value N% 15.99, H% 3.47 Pt% 55.47; theoretical value N% 15.91, H% 3.41 Pt% 55.40.

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Abstract

The invention relates to a preparation method of a platinum complex, namely tetramine platinum chloride, which belongs to the field of pharmacochemistry. The preparation method comprises the following steps: carrying out a reaction on a Magnus salt and concentrated ammonia solution under the condition of heating reflux till the green Magnus salt disappears completely so as go generate pale yellow or colorless clear liquid, and concentrating to get a solid of the tetramine platinum chloride. According to the preparation method of the tetramine platinum chloride, the higher conversation rate is kept, the cyclic utilization of byproducts can be simultaneously achieved when a target compound is synthesized, the cost is saved, and the preparation method is suitable for large-batch industrial production and conductive to environmental protection.

Description

technical field [0001] The invention relates to the preparation of a platinum complex tetraammineplatinum chloride, which belongs to the field of medicinal chemistry. Background technique [0002] Mixed aminoplatinum is a new direction for the development of platinum-based antineoplastic drugs, and its representatives Satraplatin and Meciplatin have entered the stage of Phase III clinical trials. Platinum compound K[Pt(NH 3 )Cl 3 ] is an important intermediate for the preparation of mixed amine platinum complexes, while tetraammine platinum chloride is the synthesis of K[Pt(NH 3 )Cl 3 ] One of the main reactants. Tetraamminoplatinate(II) diChloride, its full name is Tetraamminoplatinate(II) diChloride, its molecular weight is 352.14, and its chemical structure is: [0003] [0004] The traditional preparation method of tetraammineplatinum chloride is the ammoniation method of cisplatin, that is, reacting cisplatin with concentrated ammonia water at 40~50°C to obtain t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G55/00
Inventor 普绍平丛艳伟胡劲王庆琨孙加林
Owner KUNMING UNIV OF SCI & TECH
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