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Chemical synthesis method of glycocyamine

A technology of chemical synthesis of guanidinoacetic acid, applied in chemical instruments and methods, organic chemistry, preparation of organic compounds, etc., can solve the problems of poor product quality, complicated process, unsuitable for large-scale industrial production, etc., and achieve cost saving and reduction pollution effect

Inactive Publication Date: 2012-01-25
周彬
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

This method has complicated process, low yield and poor product quality, and is not suitable for large-scale industrial production.

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0009] 1. Put 150g of isopropanol, 50g of glycine and 10g of 10% sodium hydroxide solution into a 300ml reactor, stir and dissolve at room temperature, and then cool to below 5°C.

[0010] 2. Slowly add 56g of 50% cyanamide solution dropwise in the reaction kettle, the reaction temperature is controlled below 5°C, after the dropwise addition is completed, the temperature is raised to 75-80°C, stirred and refluxed for 2 hours, after the reaction is completed, concentrate under reduced pressure, evaporate The solvent was removed to obtain 72.3 g of crude product of guanidinoacetic acid.

[0011] 3. Put 72.3g of crude guanidinoacetic acid and 110g of water into a 300ml reaction kettle, stir, heat up to 85-90°C, keep warm for 30 minutes, then cool to room temperature, filter with suction, wash with a small amount of water, and decompress the wet product Dried to obtain 65 g of guanidinoacetic acid finished product, with a content greater than 99%.

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PUM

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Abstract

The invention discloses a chemical synthesis method of glycocyamine. The method comprises the following steps: 1. adding isopropanol, glycine and 10% of sodium hydroxide solution to a reactor and stirring the materials at room temperature until the materials are dissolved to obtain alkaline mixed solution; 2. dropwise adding cyanamide solution to the alkaline mixed solution, then carrying out stirring and reflex at certain temperature for a while, carrying out concentration under reduced pressure after reaction to vaporize a solvent to obtain the crude product of glycocyamine; and 3. throwing the crude product of guanidinobenzoic acid and water into the reactor, raising the temperature and stirring the materials and then carrying out leaching, washing and drying, thus finally obtaining glycocyamine. The chemical synthesis method provided by the invention is more suitable for industrial scale production.

Description

technical field [0001] The present invention relates to the chemical synthesis method of guanidinoacetic acid. Background technique [0002] Guanidinoacetic acid is a white or off-white powder, which is mainly used as animal feed additive and main raw material for chemical synthesis. According to relevant literature reports, the main production process of guanidinoacetic acid is: reacting thiourea with ethyl bromide to generate S-ethylthiourea hydrobromide, and then reacting with glycine to prepare guanidinoacetic acid. Mix thiourea, ethyl bromide and absolute ethanol and warm in a water bath for 3 hours to dissolve all thiourea. Then distill off ethanol and excess bromoethane under reduced pressure, crystallize the residue, and dry to obtain S-ethylthiourea hydrobromide. Then add sodium hydroxide solution into the obtained S-ethylthiourea hydrobromide, and quickly add the hot solution made of glycine and water under cooling. After crystallization, diethyl ether was added...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C279/14C07C277/08
Inventor 周彬
Owner 周彬
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