Application of gingkolic acid in preparation of external preparation for treating osmidrosis

Abstract

The invention relates to application of gingkolic acid in preparation of an external preparation for treating osmidrosis. The gingkolic acid comprises ginkgoic acid, ginkgol, ginkgo diphenol and the like, and can be extracted from leaf, fruit, external exotesta, rhizome and other parts of ginkgo through a chemical separation method. The osmidrosis includes the osmidrosis of axillary part, foot part, perineum and other parts. The drug, cosmetic or disinfectant external preparation containing gingkolic acid for treating osmidrosis contains 0.001-80wt% of gingkolic acid and a pharmaceutically common external preparation matrix or acceptable carrier; and the preparation is any one pharmaceutically external dosage form. Pharmacological experiment researches show that the external preparation has the effects of inhibiting the growth and propagation of bacteria on skin surface and permeating into skin to destroy large sudoriferous gland, and inhibiting the generation of free fatty acid, ammonia nitrogen compound and other smelling substances in sweat. Clinical trial shows that the external preparation has significant treatment effect on the osmidrosis, has effective rate up to 100%, is safe to use and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and therapeutic cosmetics, and in particular relates to the use of ginkgolic acid in the preparation of external preparations for treating bromidrosis. Background technique [0002] Bromidrosis can be divided into systemic bromidrosis and local bromidrosis, the latter being more common with underarm odor and foot odor. Underarm odor is a common hereditary skin metabolic disease, commonly known as body odor. Human sweat glands include small sweat glands and apocrine sweat glands. Apocrine sweat glands, also known as apocrine sweat glands and odor glands, are distributed in the armpits, perineum, feet, groin and areola. They are located at the junction of the dermis and subcutaneous tissue and in the subcutaneous tissue. In the hair follicle, the excrement is discharged from the skin surface along the hair shaft. The apocrine gland fluid that has just been discharged from the skin surface is m...

AI Technical Summary

Problems solved by technology

Topical topical drugs include topical application of antibiotics, aromatic deodorants, antiperspirants, chemical hormones, etc., the purpose of which is to reduce sweating in the armpit skin, control bacterial invasion, or mask unpleasant odors, thereby relieving symptoms; however, topical drugs currently have curative effects The maintenance time is short, and it is easy to relapse. Some patients rebound more seriously after stopping the drug, and can not achieve a true radical effect; there will also be a variety of adverse reactions, such as redness, itching and other allergic reactions at the medication site, as well as varying degrees of skin roughness , pigmentation, desquamation and other symptoms; chemical hormones can easily cause skin hardening, which will be more difficult to treat in the future, and such drugs should be avoided as much as possible

Subcutaneous injection of botulinum toxin can inhibit the secretion of sweat glands, but the effect is affected by individual differences, the effect is not durable, and repeated injections are required; and local paresthesia and bruising are prone to occur at the injection site, and antibodies will be formed in the body after multiple injections and affect the therapeutic effect

The laser treatment method will cause thermal damage to the skin and surrounding tissues during the treatment process, and has the disadvantages of incomplete treatment and a high recurrence rate after surgery

At present, surgical removal of part of the axillary skin tissue is a commonly used method to radically cure underarm odor, but this method will cause trauma and pain to the patient, including a series of complications such as pain, bleeding, incision infection, and scar contracture that affect the appearance and function. It may even affect the function of the upper limbs, and there is still a certain recurrence rate after surgery, so surgical resection is not accepted by most patients with underarm odor

There is no report on the use of ginkgolic acid in the preparation of external preparations for the treatment of bromidrosis

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