Application of gingkolic acid in preparation of external preparation for treating osmidrosis

A technology of ginkgolic acid and external preparations, applied in the field of biomedicine and therapeutic cosmetics, can solve problems such as thermal damage to the skin and surrounding tissues, affect the treatment effect, and trauma of patients, and achieve inhibition of bacterial growth and reproduction, significant therapeutic effect, and use Effect without side effects

Active Publication Date: 2012-02-15
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical topical drugs include topical application of antibiotics, aromatic deodorants, antiperspirants, chemical hormones, etc., the purpose of which is to reduce sweating in the armpit skin, control bacterial invasion, or mask unpleasant odors, thereby relieving symptoms; however, topical drugs currently have curative effects The maintenance time is short, and it is easy to relapse. Some patients rebound more seriously after stopping the drug, and can not achieve a true radical effect; there will also be a variety of adverse reactions, such as redness, itching and other allergic reactions at the medication site, as well as varying degrees of skin roughness , pigmentation, desquamation and other symptoms; chemical hormones can easily cause skin hardening, which will be more difficult to treat in the future, and such drugs should be avoided as much as possible
Subcutaneous injection of botulinum toxin can inhibit the secretion of sweat glands, but the effect is affected by individual differences, the effect is not durable, and repeated injections are required; and local paresthesia and bruising are prone to occur at the injection site, and antibodies will be formed in the body after multiple injections and affect the therapeutic effect
The laser treatment method will cause thermal damage to the skin and surrounding tissues during the treatment process, and has the disadvantages of incomplete treatment and a high recurrence rate after surgery
At present, surgical removal of part of the axillary skin tissue is a commonly used method to radically cure underarm odor, but this method will cause trauma and pain to the patient, including a series of complications such as pain, bleeding, incision infection, and scar contracture that affect the appearance and function. It may even affect the function of the upper limbs, and there is still a certain recurrence rate after surgery, so surgical resection is not accepted by most patients with underarm odor
There is no report on the use of ginkgolic acid in the preparation of external preparations for the treatment of bromidrosis

Method used

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  • Application of gingkolic acid in preparation of external preparation for treating osmidrosis
  • Application of gingkolic acid in preparation of external preparation for treating osmidrosis
  • Application of gingkolic acid in preparation of external preparation for treating osmidrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).

...

Embodiment 2

[0029]The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0030] Gi...

Embodiment 3

[0034] The extraction process of ginkgophenolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0035] Ginkgo...

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Abstract

The invention relates to application of gingkolic acid in preparation of an external preparation for treating osmidrosis. The gingkolic acid comprises ginkgoic acid, ginkgol, ginkgo diphenol and the like, and can be extracted from leaf, fruit, external exotesta, rhizome and other parts of ginkgo through a chemical separation method. The osmidrosis includes the osmidrosis of axillary part, foot part, perineum and other parts. The drug, cosmetic or disinfectant external preparation containing gingkolic acid for treating osmidrosis contains 0.001-80wt% of gingkolic acid and a pharmaceutically common external preparation matrix or acceptable carrier; and the preparation is any one pharmaceutically external dosage form. Pharmacological experiment researches show that the external preparation has the effects of inhibiting the growth and propagation of bacteria on skin surface and permeating into skin to destroy large sudoriferous gland, and inhibiting the generation of free fatty acid, ammonia nitrogen compound and other smelling substances in sweat. Clinical trial shows that the external preparation has significant treatment effect on the osmidrosis, has effective rate up to 100%, is safe to use and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and therapeutic cosmetics, and in particular relates to the use of ginkgolic acid in the preparation of external preparations for treating bromidrosis. Background technique [0002] Bromidrosis can be divided into systemic bromidrosis and local bromidrosis, the latter being more common with underarm odor and foot odor. Underarm odor is a common hereditary skin metabolic disease, commonly known as body odor. Human sweat glands include small sweat glands and apocrine sweat glands. Apocrine sweat glands, also known as apocrine sweat glands and odor glands, are distributed in the armpits, perineum, feet, groin and areola. They are located at the junction of the dermis and subcutaneous tissue and in the subcutaneous tissue. In the hair follicle, the excrement is discharged from the skin surface along the hair shaft. The apocrine gland fluid that has just been discharged from the skin surface is m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K31/05A61P17/00A61P31/02A61K8/368A61Q19/00
Inventor 王青雷红
Owner 王青
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