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Extraction method of morphine from opium

An extraction method and opium technology, applied in the field of pharmaceutical preparations, can solve the problems of complex morphine steps, low extraction yield, and use of toxic organic solvents, and achieve the effects of shortening extraction time, improving extraction efficiency, and facilitating industrialization

Inactive Publication Date: 2012-02-15
NANJING BAIJINGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problems of complex extraction of morphine from opium in the prior art, use of toxic organic solvents, and low extraction yield, and provide a method for extracting morphine from opium with simple preparation method and high yield

Method used

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  • Extraction method of morphine from opium
  • Extraction method of morphine from opium
  • Extraction method of morphine from opium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Morphine was extracted from opium with aqueous ethanol.

[0050] Include the following process steps in turn:

[0051] (1) Use ethanol aqueous solution with an opium weight-to-volume ratio of 10-20 times as the extraction solvent, with a solvent concentration of 40%-60%; heat and reflux extraction for 3 times; each extraction takes 30-60 minutes.

[0052] (2) Concentrate the three extracts obtained in (1) until the morphine content is 1-3%.

[0053] (3) Add 1-2 times the weight of opium to the concentrated solution obtained in (2) with molten solid paraffin, stir evenly, cover and let stand, discard the upper layer of solid paraffin to obtain a purified morphine solution. The morphine content was determined by HPLC, and the morphine yield was calculated.

[0054] The details and results are shown in Table 1.

[0055] Table 1 Ethanol aqueous solution extraction

[0056] serial number Solvent concentration (%) Solvent consumption (weight ...

Embodiment 2

[0058] Example 2 Pure water extraction.

[0059] (1) Use pure water to extract, the dosage is 10-20 times the opium weight, and use 60-100°C to extract 3 times, 30-60min / time.

[0060] (2) Concentrate the three extracts obtained in (1) until the morphine content is 1-3%.

[0061] (3) Add 1-2 times the weight of opium to the concentrated solution obtained in (2) with molten solid paraffin, stir evenly, cover and let stand, discard the upper layer of solid paraffin to obtain a purified morphine solution.

[0062] The details and results are shown in Table 2. The morphine content was determined by HPLC, and the morphine yield was calculated.

[0063] Table 2 Pure water extraction

[0064] serial number Solvent consumption (weight to volume ratio of opium) temperature (°C) time (minutes) yield 1 10 times 60℃ 30min / time 86.03% 2 15 times 80℃ 45min / time 93.28% 3 20 times 100℃ 60min / time 96.05%

[0065] The res...

Embodiment 3

[0066] Example 3 Dilute hydrochloric acid solution (pH=4) for extraction.

[0067] (1) Extract with dilute hydrochloric acid solution with a pH of 4, the dosage is 10-20 times the opium weight, and extract 3 times at 60-100°C, 30min-60min / time.

[0068] (2) Concentrate the three extracts obtained in (1) until the morphine content is 1-3%.

[0069] (3) Add 1-2 times the weight of opium to the concentrated solution obtained in (2) with molten solid paraffin, stir evenly, cover and let stand, discard the upper layer of solid paraffin to obtain a purified morphine solution.

[0070] The details and results are shown in Table 3. The morphine content was determined by HPLC, and the morphine yield was calculated.

[0071] Table 3 pH is 4 dilute hydrochloric acid solution extraction

[0072] serial number Solvent consumption (weight to volume ratio of opium) temperature (°C) time (minutes) yield 1 10 times 60℃ 30min / time 84.25% 2 1...

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Abstract

The invention provides an extraction method of morphine from opium. In the extraction method, the opium is taken as a main raw material, and the extraction method comprises the steps of heating and extracting aqueous solution, concentrating, performing paraffin solid-liquid extraction, removing impurities and the like so as to obtain morphine extract solution. By adopting the method, the impurities can be effectively removed, the yield is high, the preparation process is simple, the repeatability is high, the operability is good, the production cost is low, the energy consumption is low, and the industrialization is easy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a method for extracting morphine from opium. Background technique [0002] Opium, also known as opium, commonly known as opium, comes from the capsule of the poppy plant. Opium is black or brown depending on the place of origin; it has the smell of ammonia or stale urine, bitter taste and strong smell. Raw opium is cooked and fermented to produce refined opium, which is brown or golden in color. It has a sweet smell when inhaled. Opium was originally used as medicine, and it is still used in medicine at present, such as opium powder, opioid tablets, compound Jigeng powder, Tuoshi powder, and Aju tablets, etc., which are mainly used for antitussive and antidiarrheal. [0003] Morphine is the most important alkaloid in opium (content is about 10-15%). It is a kind of psychotropic drug and is an opioid receptor agonist. The molecular chemical formula is C 17 h 19 NO ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D489/02
Inventor 李丽丽陶月宝朱涛赵全如
Owner NANJING BAIJINGYU PHARMA
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