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Preparation method of cough-relieving Sichuan fritillary bulb-loguat oral liquid

The technology of loquat oral liquid and Chuanbei is applied in the field of preparation of traditional Chinese medicine preparations, and can solve the problems of low bioavailability, influence on therapeutic effect, influence on drug efficacy, etc. Effect

Inactive Publication Date: 2012-03-14
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above-mentioned extraction method cannot fully extract the active ingredients, and the bioavailability is low, thereby affecting the performance of the drug effect and directly affecting the therapeutic effect. The patient takes a large dose

Method used

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  • Preparation method of cough-relieving Sichuan fritillary bulb-loguat oral liquid
  • Preparation method of cough-relieving Sichuan fritillary bulb-loguat oral liquid

Examples

Experimental program
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Effect test

Embodiment 1

[0018] A preparation method of Chuanbei loquat oral liquid for treating cough is composed of the following steps:

[0019] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0020] (2) Decoct the loquat leaves with water for 2 times, filter, the quality of water added each time is 6 times of the quality of the loquat leaves, and the decoction time is 3 hours, and the filtrate is combined and concentrated to a clear liquid with a relative density of 1.30 at 70°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 8 hours, take the supernatant, and set aside.

[0021] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of adding ethanol is 6 times of the quality of flat fritillaria, platycodon grandiflorum and water pinellia, extracted T...

Embodiment 2

[0024] A preparation method of Chuanbei loquat oral liquid for treating cough is composed of the following steps:

[0025] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0026] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 8 times of the quality of loquat leaves, decocting time is 2 hours, combine the filtrate, concentrate to the clear liquid with a relative density of 1.30 at 60°C paste, add ethanol with 3 times the volume of the clear paste, fully stir, let stand for 10 hours, take the supernatant, and set aside.

[0027] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of ethanol added each time is 5 times of the quality of flat fritillaria, platycodon grandiflora and water pinellia, extracted The time is 2 hours; the...

Embodiment 3

[0030] A preparation method of Chuanbei loquat oral liquid for treating cough is composed of the following steps:

[0031] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0032] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 3 times of the quality of loquat leaves, decocting time is 4 hours, combine the filtrates, and concentrate to a clear liquid with a relative density of 1.30 at 75°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 6 hours, take the supernatant, and set aside.

[0033] (3) Pulverize the flat fritillaria, extract 2 times with ethanol hot reflux with platycodon grandiflorum and Pinellia syringae, filter, and the quality of adding ethanol each time is 7 times of the quality of Fritillaria chinensis, platycodon grandiflorum and pinellia water, extract The time is ...

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Abstract

The invention discloses a preparation method of a cough-relieving Sichuan fritillary bulb-loguat oral liquid. The preparation method consists of the following steps of: (1) weighing raw materials; (2) adding water into loguat leaves for decocting, filtering, concentrating into clear paste, adding ethanol, fully stirring, standing, and taking supernate out for later use; (3) smashing fritillary bulb, performing hot reflux extraction on the ground fritillary bulb, platycodon root and typhonium flagelliforme with ethanol, filtering, combining the filtrate with the supernate obtained in the step (2), recovering the ethanol, concentrating into clear paste, cooling to the room temperature, adding butanone for extracting, recovering butanone, concentrating into thick paste, drying the thick paste, smashing and screening to obtain extract powder; and (4) adding 10-50 parts by mass of distilled water and 5 parts by mass of flavoring agent into 1 part by mass of thick paste, and mixing uniformly to obtain an oral liquid. The oral liquid prepared from raw materials extracted with an extraction method disclosed by the invention has the advantages of small medicament dosage, high content, convenience for taking and carrying, good curative effect, freeness of sugar, and contribution to quantitative taking, storage and transportation.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Chuanbei loquat oral liquid for treating cough. Background technique [0002] Cough Chuanbei Pipa Dew is prepared from traditional Chinese medicine raw materials: loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract and menthol. It has antitussive and expectorant functions. For cough caused by cold and bronchitis. Its formula is: 68g of loquat leaves, 6g of platycodon grandiflorum, 20g of water pinellia, 7ml of flat fritillaria liquid extract, 0.15g of menthol. Once, filter, combine the filtrates, concentrate to an appropriate amount, add preservatives, filter, add 682g of sucrose, add flat fritillaria liquid extract and menthol in turn, add water to adjust to 1000ml, shake well, and get ready. [0003] The above-mentioned extraction method cannot fully extract the active ingredients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/08A61P11/10A61P11/14
Inventor 刘丹刘俊静佟永领
Owner 津药达仁堂集团股份有限公司第六中药厂
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