Medicament for treating kidney diseases and preparation method thereof

Abstract

The invention relates to a medicament for treating kidney diseases and a preparation method thereof, and belongs to the field of Chinese medicaments. The medicament is characterized by being prepared from the following raw materials serving as active ingredients in part by weight: 30 to 50 parts of astragalus, 30 to 50 parts of motherwort, 10 to 30 parts of lalang grass rhizome, 10 to 30 parts of polygonum aviculare, 10 to 30 parts of dianthus superbus, 10 to 30 parts of field thistle, 5 to 15 parts of pyrrosia leaf, 5 to 15 parts of garden burnet charcoal, 10 to 30 parts of dock root, and 2 to 4 parts of liquorice. The preparation method comprises the following steps of: (1) performing water extraction and alcohol precipitation on the astragalus, and filtering the extract by using a macroporous resin column to obtain an astragalus extract; (2) adding water or alcohol-water solvent into the motherwort and extracting, and filtering the extract by using an ion exchange resin column to obtain a motherwort extract; (3) adding water or alcohol-water solvent into the dock root and extracting, filtering the extract by using a macroporous adsorption resin or polyamide resin column to obtain a dock root extract; (4) performing water extraction and alcohol precipitation on the field thistle, the lalang grass rhizome, the polygonum aviculare, the dianthus superbus, the pyrrosia leaf, the garden burnet charcoal and the liquorice, to obtain seven extracts; and (5) mixing the four extracts obtained by the steps uniformly to obtain medicinal active substances. The medicinal active substances are used as medicinal effective ingredients and prepared into a preparation by using the conventional technology of pharmaceutics.

Description

Technical field [0001] The invention relates to a medicine for treating nephropathy and a preparation method thereof, and belongs to the field of traditional Chinese medicine. Background technique [0002] Nephritis is the glomerular damage caused by many reasons, which can cause changes in the permeability of the glomerular capillaries, with varying degrees of proteinuria, hematuria, white blood cell urine and cast urine. Chinese medicine believes that this is related to wind, water dampness, heat, and fatigue. [0003] As a hospital preparation, Shenyanqing Tablet has been used in Beidaihe Sanatorium of Beijing Military Region in 1979 and obtained the approval of hospital preparation, and accumulated certain clinical data during its use in the hospital. The prescription and preparation method of Shenyanqing Tablets are: Astragalus 800g, Motherwort 800g, Imperata cylindrica 400g, Acanthus 400g, Dianthus 400g, Small thistle 400g, Shiwei 160g, Sanyu charcoal 120g, Rhubarb 400g, and...

AI Technical Summary

Problems solved by technology

[0005] The traditional technology of Shenyanqing Tablets adopts the technology of water extraction and concentration for direct preparation, which basically follows the technology of traditional Chinese medicine decoction. Although this technology can retain the medicinal ingredients to a certain extent, its disadvantages are also obvious: ①Traditional decoction water The extraction process without any subsequent refining treatment makes the product have a high paste yield (the dry paste yield is more than 30%), and the patient takes a large amount (24 tablets per day), and chronic nephritis requires long-term medication. It is very difficult for patients to take it; ②The use of sugar-coated tablet technology not only greatly increases the size of the tablet, but also is not conducive to taking it by diabetic patients, especially in recent years, the diabetic nephropathy patients whose incidence has continued to rise have to be restricted; ③Extraction The process does not consider the characteristics of each medicinal taste in the prescription, so that the extraction of functional components is not complete. For example, according to literature reports, the main functional components of thistle in the prescription are flavonoids, and the main functional components of rhubarb are anthraquinone, naphthoquinone and flavonoids. , these types of compounds have better alcohol solubility, theoretically should be extracted with ethanol, but this process uses water extraction, so that the transfer rate of functional components is low and the extraction is not complete

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