Polyacrylate polymer terminated cyclodextrin polyrotaxane and preparation method thereof

Abstract

The invention discloses polyacrylate polymer terminated cyclodextrin polyrotaxane, which is characterized in that: the molecular formula is shown in the specifications; and the preparation method comprises the following steps of: preparing poly(pseudo)rotaxane physical gel from thiol polyethylene glycol and alpha-cyclodextrin; and reacting the poly(pseudo)rotaxane physical gel with an acrylate monomer under the action of an azodiisobutyronitrile radical initiator so as to connect long molecular chains of polyacrylate to two ends of the poly(pseudo)rotaxane, wherein the long molecular chains of polyacrylate serve as large-volume groups to prevent the cyclodextrin on a polyethylene glycol molecular chain from dropping off, so that the polymer terminated polyrotaxane is obtained. The number of the cyclodextrin passing through the polyethylene glycol molecular chain and the type and the length of the polyacrylate molecular chains at the two ends of the polyrotaxane can be adjusted conveniently by adjusting the using amount of the cyclodextrin and the type and the using amount of the acrylate monomer, so that the performance of the polyrotaxane can be adjusted conveniently. The polyrotaxane is a novel supermolecular system and can be applied to the fields of biodegradable materials, medicine carriers, sustained release materials, biosensors and the like.

Description

technical field

[0001] The invention relates to a polymer-terminated cyclodextrin polyrotaxane and a preparation method thereof, in particular to a polyacrylate polymer-terminated cyclodextrin polyrotaxane and a preparation method thereof. Background technique

[0002] Since Lehn's excellent lecture on supramolecular chemistry in 1988, polyrotaxanes have risen rapidly as important members of this emerging field. The so-called polyrotaxane refers to a supramolecular polymer prepared by using multiple cyclic molecules, such as cyclodextrin, on a long-chain linear molecular axis and capping with bulky groups; Bulk group-terminated, it is called polypseudorotaxane. At present, when polyrotaxanes are used as materials, the main problems include the following aspects: first, the end-capping problem. Because there are no bulky groups at both ends of polypseudorotaxane, the structure is unstable, and cyclodextrin is easy to fall off from the linear molecular chain, thus limiting i...

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