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Polyacrylate polymer terminated cyclodextrin polyrotaxane and preparation method thereof

A polyacrylate and cyclodextrin technology, applied in the field of polymer-terminated cyclodextrin polyrotaxane and its preparation, can solve problems such as single method, and achieve the effect of low price and widening scope

Inactive Publication Date: 2012-03-28
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the sites available for modification reactions on polyrotaxanes are mainly on cyclodextrins, the modification method is mainly to introduce functional groups on cyclodextrins, and the method is relatively simple.

Method used

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  • Polyacrylate polymer terminated cyclodextrin polyrotaxane and preparation method thereof
  • Polyacrylate polymer terminated cyclodextrin polyrotaxane and preparation method thereof
  • Polyacrylate polymer terminated cyclodextrin polyrotaxane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Step a: at room temperature, 5 grams of polyethylene glycol dimercaptoacetate (average molecular weight 6100) aqueous solution with a mass percent concentration of 15% and 42.5 grams of an α-cyclodextrin aqueous solution with a mass percent concentration of 11.27% were stirred Mix evenly, wherein the molar ratio of polyethylene glycol dimercaptoacetate to α-cyclodextrin is 1:40; the mixed solution is left to stand at room temperature for 24 hours to obtain a non-flowing gel-like polypseudorotaxane physical condensation glue;

[0025] Step b: Add 4 grams of dimethylaminoethyl acrylate monomer and 8 mg of azobisisobutyronitrile free radical initiator powder to the polypseudorotaxane physical gel obtained above, stir and mix evenly to obtain a white Heterogeneous suspension; the above-mentioned white heterogeneous suspension was placed in a 365 nm ultraviolet dark box analyzer and reacted for 28 hours;

[0026] Step c: After the reaction is completed, add 400 milliliters ...

Embodiment 2

[0036]Step a: at room temperature, 5 grams of polyethylene glycol dimercapto propionate (average molecular weight 10200) aqueous solution and 50 grams of α-cyclodextrin aqueous solution with a mass percent concentration of 11.27% were stirred under the condition of stirring Mix evenly, wherein the molar ratio of polyethylene glycol dimercaptopropionate to α-cyclodextrin is 1:47; the mixed solution is allowed to stand at room temperature for 24 hours to obtain a non-flowing gel-like polypseudorotaxane physical condensation glue;

[0037] Step b: Add 10 grams of dimethylformamide solution of 30% n-butyl acrylate monomer and 30 mg of azobisisobutyronitrile free radical to the polypseudorotaxane physical gel obtained above Initiator powder, obtain a kind of white heterogeneous suspension after stirring and mixing; Above-mentioned white heterogeneous suspension is placed in 365 nanometer ultraviolet dark box analyzer and reacted for 18 hours;

[0038] Step c: After the reaction is...

Embodiment 3

[0044] Step a: at room temperature, 5 grams of polyethylene glycol dimercaptopropionate (average molecular weight 4200) aqueous solution and 10 grams of α-cyclodextrin aqueous solution with a mass percent concentration of 11.27% were stirred under the condition of stirring Mix evenly, wherein the molar ratio of polyethylene glycol dimercaptopropionate to α-cyclodextrin is 1:9.7; the mixed solution is allowed to stand at room temperature for 24 hours to obtain a non-flowing gel-like polypseudorotaxane physical condensation glue;

[0045] Step b: Add 20 grams of dimethyl methacrylate monomer solution in dimethylformamide with a mass percent concentration of 20% and 80 mg of azobisisobutyronitrile free Base initiator powder, after stirring and mixing, obtain a kind of white heterogeneous suspension; Above-mentioned white heterogeneous suspension is placed in 365 nanometer ultraviolet dark box analyzer and reacted for 24 hours;

[0046] Step c: After the reaction is completed, ad...

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Abstract

The invention discloses polyacrylate polymer terminated cyclodextrin polyrotaxane, which is characterized in that: the molecular formula is shown in the specifications; and the preparation method comprises the following steps of: preparing poly(pseudo)rotaxane physical gel from thiol polyethylene glycol and alpha-cyclodextrin; and reacting the poly(pseudo)rotaxane physical gel with an acrylate monomer under the action of an azodiisobutyronitrile radical initiator so as to connect long molecular chains of polyacrylate to two ends of the poly(pseudo)rotaxane, wherein the long molecular chains of polyacrylate serve as large-volume groups to prevent the cyclodextrin on a polyethylene glycol molecular chain from dropping off, so that the polymer terminated polyrotaxane is obtained. The number of the cyclodextrin passing through the polyethylene glycol molecular chain and the type and the length of the polyacrylate molecular chains at the two ends of the polyrotaxane can be adjusted conveniently by adjusting the using amount of the cyclodextrin and the type and the using amount of the acrylate monomer, so that the performance of the polyrotaxane can be adjusted conveniently. The polyrotaxane is a novel supermolecular system and can be applied to the fields of biodegradable materials, medicine carriers, sustained release materials, biosensors and the like.

Description

technical field [0001] The invention relates to a polymer-terminated cyclodextrin polyrotaxane and a preparation method thereof, in particular to a polyacrylate polymer-terminated cyclodextrin polyrotaxane and a preparation method thereof. Background technique [0002] Since Lehn's excellent lecture on supramolecular chemistry in 1988, polyrotaxanes have risen rapidly as important members of this emerging field. The so-called polyrotaxane refers to a supramolecular polymer prepared by using multiple cyclic molecules, such as cyclodextrin, on a long-chain linear molecular axis and capping with bulky groups; Bulk group-terminated, it is called polypseudorotaxane. At present, when polyrotaxanes are used as materials, the main problems include the following aspects: first, the end-capping problem. Because there are no bulky groups at both ends of polypseudorotaxane, the structure is unstable, and cyclodextrin is easy to fall off from the linear molecular chain, thus limiting i...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/34C08F220/18C08F220/14C08B37/16
Inventor 于怀清丛日敏
Owner SHANDONG UNIV OF TECH
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