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Chinese medicinal composition for reversing multi-drug resistance of tumor and preparation method and application thereof

A technology of multi-drug resistance and composition, which is applied in the direction of drug combination, antineoplastic drugs, pharmaceutical formulations, etc., to achieve the effect of reversing tumor multi-drug resistance, improving curative effect, and significantly tumor multi-drug resistance

Inactive Publication Date: 2012-04-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Chinese invention patent CN200710070320.4 discloses "the use of curcumin in the preparation of tumor multidrug resistance preventive agents", and Chinese invention patent CN200710143393.1 discloses "the application of artemisinin in the preparation of anti-tumor multidrug resistance drugs" ; but there are fewer reports about the traditional Chinese medicine composition as a tumor multidrug resistance reversal agent at present

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  • Chinese medicinal composition for reversing multi-drug resistance of tumor and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0028] Preparation of traditional Chinese medicine composition for reversing tumor multidrug resistance:

[0029] (1) Weigh 100g of mountain bean root, 300g of Baiying, 100g of kudingcha, 300g of leaves and 100g of bougainvillea, mix them, add 9 times the total weight of each traditional Chinese medicine raw material, soak in water for 2 hours, heat and decoct for 1.5h, Pour out the decoction; the dregs of the medicine are added with 8 times the total weight of each traditional Chinese medicine raw material, heated and decocted for 1.5 hours, poured out the decoction, combined and filtered the decoction obtained from the two decoctions to obtain a clear liquid;

[0030] (2) When the clear liquid is concentrated to a relative density of 1.05, it is sent to a spray dryer for spray drying, the inlet air temperature is controlled at 140°C, the outlet air temperature is 100°C, the atomizer speed is 50 rpm, and the feed speed 3ml / min to obtain 30 grams of spray-dried powder; the spr...

Embodiment 2

[0032] Preparation of traditional Chinese medicine composition for reversing tumor multidrug resistance:

[0033] (1) Weigh 300g of Chinese herbal medicine raw materials Shandougen, 100g of Baiying, 300g of Kudingcha, 100g of Ayurveda frondosa and 300g of Bougainvillea bougainvillea, after mixing, add 10 times the total weight of each Chinese medicine raw material, soak in water for 3 hours, heat and decoct for 2 hours , pouring out the decoction; the dregs plus 8 times the total weight of each traditional Chinese medicine raw material, heated and decocted for 1 hour, poured out the decoction, combined and filtered the decoction obtained from the two decoctions to obtain a clear liquid;

[0034] (2) When the clear liquid is concentrated to a relative density of 1.05, it enters the spray dryer, the inlet air temperature is controlled at 140°C, the outlet air temperature is 100°C, the rotation speed of the atomizer is 50 rpm, and the feed rate is 3ml / min to obtain a spray 50 gra...

Embodiment 3

[0036] Preparation of traditional Chinese medicine composition for reversing tumor multidrug resistance:

[0037] (1) Weigh 120g of Chinese herbal raw materials Shandougen, 120g of Baiying, 180g of Kudingcha, 120g of Ayurveda leaves, and 180g of Bougainvillea, mix them, add 9.5 times the total weight of each Chinese herbal raw material, soak in water for 2.5 hours, heat and decoct for 2 hours , pouring out the decoction; the dregs plus 9 times the total weight of each traditional Chinese medicine raw material, heated for 1 hour, poured out the decoction, combined and filtered the decoction obtained from the two decoctions to obtain a clear liquid;

[0038] (2) When the clear liquid is concentrated to a relative density of 1.06, it enters the spray dryer, the inlet air temperature is controlled at 160°C, the outlet air temperature is 110°C, the rotation speed of the atomizer is 60 rpm, and the feed rate is 5ml / min to obtain a spray 30 grams of dry powder; the spray-dried powder...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses a Chinese medicinal composition for reversing multi-drug resistance of tumor and a preparation method and an application thereof. The Chinese medicinal composition is made of the following Chinese medicinal herb raw materials by weight part: 10 to 30 parts of subprostrate sophora, 10 to 30 parts of climbing nightshade, 10 to 30 parts of broadleaf holly leaves, 10 to 30 parts of Cacumen Biotae and 10 to 30 parts of Bougainvillea spectabilis Willd.; the above Chinese medicinal raw materials are immersed in the water for 2 to 3 hours after being mixed, decocted liquid is poured out after the raw materials are heated and decocted, then water is added into the raw materials to be decocted, the decocted liquid is poured out, the decocted liquid is filtered after being mixed, the obtained clear liquid is concentrated, atomized, dried and screened after being pulverized to obtain the Chinese medicinal composition for reversing the multi-drug resistance of tumor. Blood serum of the Chinese medicinal composition is combined with adriamycin to use, 50% inhibitory concentration of adriamycin on leukemia cell adriamycin persister is remarkably reduced, the reversing times are 2.87 to 4.37 and is positively correlated to the concentration, and a remarkable effect on reversing the multi-drug resistance of tumor can be realized.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for reversing tumor multidrug resistance, a preparation method and application thereof. technical background [0002] Multidrug resistance (MDR) of tumor cells to anticancer drugs is a common factor leading to the failure of tumor chemotherapy. At present, the prevalence of cancer in China is on the rise, and the death of 90% of cancer patients is affected by the drug resistance of tumor cells to varying degrees. Therefore, it is necessary to develop a new generation of drug resistance reversal agents. It is known that some traditional Chinese medicines have calcium antagonistic effects, and the drug effects are relatively mild, and can improve the effect of chemotherapy in reversing MDR, so they have good application and development prospects. [0003] The results of the study showed that a variety of mechanisms are involved i...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P35/00
Inventor 蔡宇张荣华
Owner JINAN UNIVERSITY
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