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One-spot method for converting lutein ester into zeaxanthin

A technology of zeaxanthin and lutein ester, applied in chemical instruments and methods, organic chemistry, azo dyes, etc., can solve the problems of low conversion rate and cumbersome steps, and achieve high yield, simple operation and simple steps short effect

Inactive Publication Date: 2012-04-04
NANCHANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In the existing technology, there is a technology of converting lutein esters into zeaxanthin, first saponifying the lutein esters, separating and extracting lutein monomers and then converting them into zeaxanthin, but the steps are cumbersome and the conversion rate is not high

Method used

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  • One-spot method for converting lutein ester into zeaxanthin
  • One-spot method for converting lutein ester into zeaxanthin

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Under the protection of nitrogen, measure 5mL of 1,2-propanediol in a 25mL three-neck flask, heat up to 80°C, weigh 0.5g of lutein extract and dissolve it in the solvent. After the lutein is dissolved, weigh 2g of solid hydrogen Potassium oxide was added to the reaction solution, the temperature was raised to 110°C, and the reaction was kept for 48 hours. Add 10 volumes of distilled water, stir evenly, adjust the pH to neutral with 25% acetic acid, then filter, and wash the filter cake with distilled water 3 times to remove residual chemicals and various salts. The cake was vacuum dried. As determined by HPLC, lutein accounts for 6% and zeaxanthin accounts for 88%.

Embodiment 2

[0028] Under the protection of nitrogen, measure 30mL of 1,2-propanediol in a 100 mL three-neck flask, heat up to 60°C, weigh 3g of lutein extract and dissolve it in the solvent. After the lutein extract is dissolved, weigh 15g Solid potassium hydroxide was added to the reaction solution, the temperature was raised to 110°C, and the reaction was kept for 48 hours. Add 10 volumes of distilled water, stir evenly, adjust the pH to neutral with 25% acetic acid, then filter, and wash the filter cake with distilled water 3 times to remove residual chemicals and various salts. The cake was vacuum dried. As determined by HPLC, lutein accounts for 5% and zeaxanthin accounts for 91%.

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Abstract

The invention discloses a one-spot method for converting lutein ester into zeaxanthin, which is characterized by comprising the following steps of: (1) under the protection of nitrogen, heating a solvent to the temperature of between 50 and 80DEG C, adding a lutein extract into the solvent in a mass / volume ratio of 1:(5-20), adding alkali in a mass ratio of the lutein extract to the alkali of 1:(1-6), heating to the temperature of between 80 and 150DEG C, and reacting by keeping the temperature for 10 to 72 hours until the reaction is finished; and (2) adding water to stop the reaction, adding 5 to 45 volume percent acid to neutralize until the pH value is 4-7, filtering, washing, and performing vacuum drying at the temperature of between 30 and 50DEG C to obtain high-purity zeaxanthin. In the method, the lutein extract is not required to be saponified, the steps are simple and short, the operation is simple, the yield is high, and the used organic solvent and reagents have low toxicity or no toxicity. The prepared zeaxanthin can be further purified to form a zeaxanthin monomer and used for preparing zeaxanthin microcapsules.

Description

technical field [0001] The invention relates to a method for converting lutein esters into zeaxanthin in one pot. Background technique [0002] Carotenoids are the general term for two types of pigments, carotene and lutein. Carotenoids are a class of very important pigments that exist in animals and plants, and these pigments are widely used in food additives. Among them, lutein and zeaxanthin are the most widely used. [0003] Lutein is 3,3 ， - Dihydroxy-α-carotene, which belongs to the family of hydroxyl-containing carotenoids. Zeaxanthin is 3,3 , -Dihydroxy-β-carotene, which is isomers with lutein. Their structural formulas are as follows: [0004] [0005] Lutein [0006] [0007] Zeaxanthin [0008] Lutein and zeaxanthin can be used as feed additives for the coloring of poultry meat and eggs, and have also been used as coloring and nutritional health agents in the food industry. Lutein and zeaxanthin are also a class of antioxidants with excellent perf...

Claims

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Application Information

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IPC IPC(8): C07C403/24C09B61/00
Inventor 陆豫陈佳余勃张贵林
Owner NANCHANG UNIV
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