Medicinal slow release inserted slice possessing layer-by-layer assembly mosaic structure

A layer-by-layer assembly and mosaic technology, which is applied in medical science, making drugs into special physical or ingestible devices, pill delivery, etc., can solve the problems of short validity period, hard material, complicated process, etc., to achieve simple operation, The effect of low cost and simple process

Active Publication Date: 2013-03-13
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The problem to be solved by the present invention is to improve the complex process, hard material, and short validity period of implanting drug sustained-release substances in the background art.

Method used

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  • Medicinal slow release inserted slice possessing layer-by-layer assembly mosaic structure
  • Medicinal slow release inserted slice possessing layer-by-layer assembly mosaic structure
  • Medicinal slow release inserted slice possessing layer-by-layer assembly mosaic structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Prepare the mixed solution of polycaprolactone / triamcinolone acetonide:

[0048] First, dissolve polycaprolactone with a number average molecular weight of 20,000 in dichloromethane to prepare a solution a with a solid phase concentration of 10 mg / ml; then dissolve triamcinolone acetonide in acetone to prepare a drug solution with a concentration of 5 mg / ml b; according to the requirements of the drug loading, take two solutions of appropriate volumes and mix them, and after half an hour of closed ultrasonication, stand-by;

[0049] (2) Spraying:

[0050] Using spraying equipment, the pressure is selected as 0.15MPa, and the mixed solution is sprayed onto the collecting plate that has been heated to 40°C in advance;

[0051] (3) Introduce hot air:

[0052] After 20 seconds of spraying each time, pass hot air at 40°C over the collecting plate for 15 seconds; repeat this process until the plant reaches the actual required thickness;

[0053] (4) Drying:

[0054] P...

Embodiment 2

[0060] (1) Prepare a mixed solution of polycaprolactone / tacrolimus:

[0061] First, dissolve polycaprolactone with a number average molecular weight of 20,000 in dichloromethane to prepare a solution a with a solid phase concentration of 75 mg / ml; then dissolve tacrolimus in acetone to prepare a drug with a concentration of 3 mg / ml Solution b; according to the requirements of the drug loading, take two solutions of appropriate volumes and mix them, and after half an hour of closed ultrasonication, stand-by;

[0062] (2) Spraying:

[0063] Using spraying equipment, the pressure is selected as 0.3MPa, and the mixed solution is sprayed onto the collecting plate that has been heated to 60°C in advance;

[0064] (3) Introduce hot air:

[0065] After 40 seconds of spraying each time, pass hot air at 60°C over the collecting plate for 45 seconds; repeat this process until the plant reaches the actual required thickness;

[0066] (4) Drying:

[0067] The sample is placed in a vacu...

Embodiment 3

[0071] (1) Prepare the mixed solution of polycaprolactone / triamcinolone acetonide:

[0072] First, dissolve polycaprolactone with a number average molecular weight of 80,000 in dichloromethane to prepare a solution a with a solid phase concentration of 10 mg / ml; then dissolve triamcinolone acetonide in acetone to prepare a drug solution with a concentration of 7 mg / ml b; according to the requirements of the drug loading, take two solutions of appropriate volumes and mix them, and after half an hour of closed ultrasonication, stand-by;

[0073] (2) Spraying:

[0074] Using spraying equipment, the pressure is selected as 0.15MPa, and the mixed solution is sprayed onto the collecting plate that has been heated to 40°C in advance;

[0075] (3) Introduce hot air:

[0076] After 20 seconds of spraying each time, pass hot air at 40°C over the collecting plate for 15 seconds; repeat this process until the plant reaches the actual required thickness;

[0077] (4) Drying:

[0078] P...

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Abstract

The invention discloses a medicinal slow release inserted slice possessing a layer-by-layer assembly mosaic structure, the inserted slice is prepared by the following steps: preparing a polymer, mixing a medicine with a solution, spraying, passing through hot air, drying, moulding and the like. During the process of preparing the slow release type drug loaded inserted slice, the structure of the inserted slice can be controlled by adjusting pressure, temperature and spraying time, thereby the medicine release rate and degradation time of the inserted slice can be influenced for meeting the requirement of insertion, simultaneously the mechanical property of the inserted slice is influenced, so that the inserted slice possessing appropriate flexibility is obtained, and is convenient for better clinical application.

Description

technical field [0001] The invention relates to the technical field of drug sustained-release carriers, in particular to a method for preparing implantable drug sustained-release implants capable of long-term administration. Background technique [0002] Implantable controlled-release drug delivery system is a kind of controlled-release drug preparation that is surgically implanted subcutaneously or introduced subcutaneously through a puncture needle. With the development of medical technology, great progress has been made in the research of carrier materials and their application range. The carrier has developed from the initial single silicone rubber to dozens of biodegradable materials such as ε-polycaprolactone, polyanhydride, polylactic acid, polyamino acid, etc., as well as the latest reports of silica sol, hydroxyapatite Wait. Polymer drug sustained-release system is an ideal local slow drug delivery method. Polylactic acid and polyglycolic acid copolymer (PLGA), as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K47/34A61J3/00A61L31/14
Inventor 程凌云孟永春南开辉孙树茂陈浩
Owner WENZHOU MEDICAL UNIV
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