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Antihypoxic medicinal composition and preparation method and application thereof

A technology of anti-hypoxic drugs and compositions, applied in drug combinations, pharmaceutical formulas, anti-toxins, etc., can solve problems such as unclear curative effects, large side effects, and difficulty in mass equipment, so as to relieve symptoms of chest tightness and shortness of breath, and enhance hypoxia resistance effect of ability

Inactive Publication Date: 2012-04-11
LOGISTICS UNIV OF CAPF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although our army already has medicines, adjuvants, equipment, programs and manuals for the prevention and treatment of acute altitude sickness, these prevention and control measures have shortcomings such as slow onset of effect, large side effects, unclear curative effect, and difficulty in equipping troops in large numbers.

Method used

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  • Antihypoxic medicinal composition and preparation method and application thereof
  • Antihypoxic medicinal composition and preparation method and application thereof
  • Antihypoxic medicinal composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of an anti-hypoxia pharmaceutical composition, comprising the following steps: weigh Potentilla, Rhodiola rosea and Pueraria lobata root as raw materials in a mass ratio of 3:3:1, pulverize, and add 6 mass times the volume concentration of the raw materials to 30 % Ethanol aqueous solution, heated at reflux for extraction for 2 hours, filtered, concentrated the filtrate to 1 / 8 of the volume of the filtrate to obtain a concentrated solution, and added 6 times the volume of the concentrated solution to the concentrated solution and precipitated with 75% aqueous ethanol solution for 12 hours , Filter, discard the precipitate, and concentrate and dry the filtrate to obtain a brown-yellow anti-hypoxic pharmaceutical composition powder.

Embodiment 2

[0023] A preparation method of an anti-hypoxia pharmaceutical composition, including the following steps: weigh Potentilla, Rhodiola rosea and Pueraria lobata root as raw materials in a mass ratio of 1:1:2, crush them, and add 10 mass times the volume concentration of the raw materials to 40 % Ethanol aqueous solution, heated and refluxed for 1 hour, filtered, and concentrated the filtrate to 1 / 6 of the volume of the filtrate to obtain a concentrated solution. To the concentrated solution, 5 times the volume of the concentrated solution was added to the 85% aqueous solution of ethanol for precipitation for 10 hours , Filter, discard the precipitate, and concentrate and dry the filtrate to obtain a brown-yellow anti-hypoxic pharmaceutical composition powder.

Embodiment 3

[0025] A preparation method of an anti-hypoxia pharmaceutical composition, comprising the following steps: weigh Potentilla, Rhodiola rosea and Pueraria lobata root as raw materials in a mass ratio of 3:3:0.5, pulverize, add 6 mass times water of the raw materials, and heat to reflux Extract for 3 hours, filter, and concentrate the filtrate to 1 / 10 of the volume of the filtrate to obtain a concentrated solution. Add 7 times the volume of the concentrated solution to the concentrated solution with a 65% volume concentration of ethanol aqueous solution for 14 hours, filter, and discard the precipitate. The filtrate is concentrated and dried to obtain a brown-yellow anti-hypoxic pharmaceutical composition powder.

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Abstract

The invention discloses an antihypoxic medicinal composition and a preparation method and application thereof. The preparation method of the medicinal composition comprises the following steps of: weighing argentina anserina, rhodiola rosea and kudzuvine root which are used as the raw materials according to a mass ratio of (1 to 5):(1 to 5): (0.5 to 2); grinding the raw materials; adding an aqueous solution of ethanol with the volume concentration of 0 to 40 percent, wherein the mass of the aqueous solution of ethanol is 6 to 10 times of the mass of the raw materials; heating and carrying out refluxing extraction for 1 to 3 hours; filtering; concentrating filtrate to one sixth to one tenth of the volume of the filtrate so as to obtain a concentrated solution; adding an aqueous solution of ethanol with the volume concentration of 65 to 95 percent to carry out alcohol precipitation for 10 to 14 hours, wherein the volume of the aqueous solution of ethanol is equivalent to 5 to 7 times of the volume of the concentrated solution; filtering; abandoning the precipitates; and drying and concentrating the obtained filtrate to obtain claybank antihypoxic medicinal composition powder. The medicinal composition disclosed by the invention can be used for strengthening the antihypoxic capability of a mouse and can be used for improving the oxyhemoglobin saturation of highland people, reducing heart rate acceleration of people who first enter the plateau, which is caused by oxygen deprivation, and relieving the symptoms of chest distress and shortness of breath.

Description

Technical field [0001] The invention relates to a pharmaceutical composition containing Potentilla anserina, Rhodiola rosea and Pueraria lobata root, and the application of the pharmaceutical composition in the preparation of anti-hypoxia drugs. Background technique: [0002] Oxygen is an important condition for humans and many living things to survive. When the oxygen required for the body's life activities cannot be adequately supplied, it is called hypoxia or hypoxia. Hypoxia will cause abnormal changes in the body's metabolism, function, and even morphology. Severe or long-term hypoxia will bring serious harm to the body, and eventually lead to the death of vital organs such as the heart and brain due to insufficient energy supply. Oxygen and hypoxia are important topics in the basic theories of life sciences. The formation of hypoxia can be divided into three categories: the first category is the decrease in the oxygen content of the external environment, which makes it i...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P9/10A61P39/00
Inventor 李灵芝张永亮崔颖李建宇张丽顾军李宏伟段晓彦郭鹏龚海英
Owner LOGISTICS UNIV OF CAPF