Oligoden droglioma (OG) marker MAP2 (microtubuleassociated protein 2) protein and use thereof

A glioma, marker technology, applied in the field of biotechnology and medicine, can solve the problems of cumbersome process and high cost
CN102408478AInactive Publication Date: 2012-04-11FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUDAN UNIV
Publication Date
2012-04-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biotechnology and medicine, relates to oligoden droglioma (OG) markers, and particularly relates to a protein marker MAP2 (microtubuleassociated protein 2) protein which can differentiate OG that clinically has sensitivity to chemotherapy and 1P loss of heterozygosity (1P LOH), and use thereof. According to the invention, the protein marker MAP2 protein which can differentiate the OG that clinically has sensitivity to chemotherapy and 1P loss is determined through the iTRAQ-LC-MS / MS technology. The MAP2 protein has 90% accuracy for the prognosis of the 1P loss. The marker not only can explain the mechanism for the sensitivity to chemotherapy of an OG sample with the 1P LOH, but also can prognose the sensitivity to chemotherapy of an OG patient with the 1P LOH through a decision tree model. The MAP2 protein can be further used for preparing a clinical kit so as to offer help for the diagnosis, the prognosis and the treatment of the OG.
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Description

technical field

[0001] The invention belongs to the fields of biotechnology and medicine. It relates to markers of human oligodendroglioma, in particular to a human oligodendroglioma (Oligoden droglioma) capable of distinguishing clinically chemotherapy-sensitive, 1p allele heterozygous loss (1p Loss of heterozygosity, 1p LOH) , OG) protein marker MAP2 protein (microtubulea associated protein 2, MAP2) and its use. Background technique

[0002] Biomarkers refer to physical, chemical, or biological indicators that can be objectively measured, indicating normal physiological or pathological processes, or the body's response to drugs. One of the most critical issues in modern tumor research is to find markers for early detection, diagnostic typing, treatment monitoring and prognosis, and drug targets. Studies have revealed a series of changes in the intracellular protein expression profile during the transition from a normal state to a tumor. Tumor markers are a class of subs...

Claims

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