Ion generation using wetted porous material
A technique for porous materials, ions, applied in methods using particle spectrometers, analytical materials, ion sources/guns, etc.
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example 1
[0088] Example 1: Constructing MS Probes
[0089] Filter paper was cut into triangular pieces 10 mm long and 5 mm wide and used as nebulizers (Figure 1). Attach the copper clips to the paper, with the paper facing the inlet of the mass spectrometer (Figure 1). Install the copper clip on the 3D mobile stage to adjust its position accurately. A high voltage is applied to the copper clip and controlled by the mass spectrometer to generate analyte ions for mass spectrometric detection.
[0090] Apply the sample directly to the paper surface used as a sample purification and pre-concentration device. The filter paper allows the liquid sample to move through the hydrophilic network driven by capillary action and electric effect, and transports the liquid sample to the paper tip. Separation may occur during this transfer process. Upon application of a high voltage (~4.5 kV) to the paper surface, the sample solution was ejected from the paper tip and ionization and MS detection ...
example 2
[0092] Example 2: Generating a spray
[0093] The spray can be produced by applying a high potential to a moistened paper triangle. Place a paper triangle in front of the inlet of the LTQ with the tip of the paper triangle facing the inlet and separated from the inlet by 3 mm or more. Typically, 10 uL of sample solution was applied to wet the paper triangle. The solution may wet or saturate the paper or form a thin film layer of liquid on the surface of the paper. A high potential (3-5 kV) was applied between the paper triangle and the inlet of the mass spectrometer to generate an electric field, which induced charge accumulation on the liquid at the tip of the paper triangle. Increasing Coulombic forces break up the liquid to form charged droplets, and the solvent evaporates as the droplets splash from the paper tip to the mass spectrometer. Solvent removal using a paper sprayer does not require sheath gas, heat, or any other aids.
[0094] When fluid accumulates on a p...
example 3
[0095] Example 3: Probe Considerations
[0096] Probe material
[0097] A wide variety of porous materials can be tested to generate charged droplets for mass spectrometry. The material may be in the shape of a triangle with a tip, and the sample solution is then applied to the constructed probe. The data in this patent application document shows that any hydrophilic porous substrate can be used successfully, including cotton yarns, fabrics, plant tissue, and different kinds of paper. The porous network or microchannels of these materials provide sufficient space for liquid retention, and the hydrophilic environment enables liquid transport by capillary action. Hydrophobic porous substrates can also be successfully used with an appropriate selection of hydrophobic solvents.
[0098] After further investigation, six commercially available papers were selected and qualitatively tested to assess whether they could be used to detect an analyte. Filter paper and chromatograph...
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