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Preparation method of synthesized D-glucosamine sulfate sodium

A technology of glucosamine sulfate sodium salt and reactor is applied in the field of preparation of synthetic D-glucosamine sulfate sodium salt, and can solve the problems of different material densities of glucosamine sulfate sodium salt, unstable glucosamine sulfate, poor uniformity and the like , to achieve the effect of high purity, less impurities and low cost

Inactive Publication Date: 2012-04-18
YANGZHOU HONGXIN BIOLOGICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The prior art glucosamine sulfate is extremely unstable, hygroscopic and easily oxidized
Moreover, the existing physically mixed glucosamine sulfate sodium salt materials have different densities and poor uniformity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] A preparation method for synthesizing D-glucosamine sulfate sodium salt, comprising the following steps:

[0012] A. Dissolution: Add water into the reactor, heat to 70°C, add sodium sulfate under stirring condition, after it dissolves, lower the temperature to 60°C, add D-glucosamine hydrochloride, continue stirring, wait After it dissolves, raise the temperature of the solution to 65°C, add an organic solvent, cool down to 15°C, and continue to stir for 10 hours, so that all materials are fully reacted in the reactor;

[0013] B. Crystallization: cool down the above-mentioned reacted materials to 0°C, crystallize under stirring conditions for 90 minutes, and then centrifuge and dehydrate in a centrifuge to obtain white crystals;

[0014] C. Drying: drying the centrifuged white crystals under vacuum at a temperature of 55° C. to obtain synthetic D-glucosamine sulfate sodium salt.

Embodiment 2

[0016] A preparation method for synthesizing D-glucosamine sulfate sodium salt, comprising the following steps:

[0017] A. Dissolution: Add water into the reactor, heat to 80°C, add sodium sulfate under stirring condition, after it dissolves, lower the temperature to 65°C, add D-glucosamine hydrochloride, continue stirring, wait After it dissolves, raise the temperature of the solution to 75°C, add an organic solvent, cool down to 25°C, and continue stirring for 15 hours, so that all materials are fully reacted in the reactor;

[0018] B. Crystallization: Cool down the above-mentioned reacted materials to -10°C, crystallize under stirring conditions for 120 minutes, and then centrifuge and dehydrate in a centrifuge to obtain white crystals;

[0019] C. Drying: drying the centrifuged white crystals under vacuum at a temperature of 65° C. to obtain synthetic D-glucosamine sulfate sodium salt.

Embodiment 3

[0021] A preparation method for synthesizing D-glucosamine sulfate sodium salt, comprising the following steps:

[0022] A. Dissolution: Add water into the reactor, heat to 75°C, add sodium sulfate under stirring condition, after it dissolves, lower the temperature to 62°C, add D-glucosamine hydrochloride, continue stirring, wait After it dissolves, the temperature of the solution is raised to 70°C, an organic solvent is added, the temperature is lowered to 20°C, and stirring is continued for 12 hours, so that all materials are fully reacted in the reactor;

[0023] B. Crystallization: Cool down the above-mentioned reacted materials to -5°C, crystallize under stirring conditions for 105 minutes, and then centrifuge and dehydrate in a centrifuge to obtain white crystals;

[0024] C. Drying: drying the centrifuged white crystals under vacuum at a temperature of 60° C. to obtain synthetic D-glucosamine sulfate sodium salt.

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PUM

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Abstract

The invention provides a preparation method of a synthesized D-glucosamine sulfate sodium. The method comprises the following steps of dissolving, crystallization and drying. The synthesized D-glucosamine sulfate sodium of the present invention has advantages of simple process flow, low cost and benefit for industrialized production; and the synthesized D-glucosamine sulfate sodium prepared by the method of the invention has high purity, little impurity and good curative effect.

Description

technical field [0001] The invention belongs to the technical fields of marine resources and medicine and chemical industry, and in particular relates to a preparation method for synthesizing D-glucosamine sulfate sodium salt. Background technique [0002] The prior art glucosamine sulfate is extremely unstable, hygroscopic and easily oxidized. Moreover, the existing physically mixed glucosamine sulfate sodium salt materials have different densities and poor uniformity. Contents of the invention [0003] The purpose of the invention is to overcome the deficiencies in the prior art and provide a preparation method for synthesizing D-glucosamine sulfate sodium salt. [0004] Technical scheme of the present invention is: a kind of preparation method of synthetic D-glucosamine sulfate sodium salt, comprises the following steps: [0005] A. Dissolution: Add water to the reactor, heat to 70°C-80°C, add sodium sulfate under stirring condition, after it dissolves, lower the temp...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H1/00
Inventor 杨生桂
Owner YANGZHOU HONGXIN BIOLOGICAL PRODS
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