A porous scaffold with network channels and its preparation method

A technology of network channels and porous scaffolds, applied in the field of biomaterials and regenerative medicine, can solve the problem of no difference in function

Inactive Publication Date: 2016-03-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

LuJX et al. [BaiF, et al. Tissue Engineering Part A .2010,16:3791-3803] have done a lot of research on the connection path of scaffold pores. They implanted the β-tricalcium phosphate (β-TCP) porous material with precise pore size and connection path into animals to study the blood vessel. It was found that the connecting diameter is more important than the pore size for blood vessel formation, but when the pore size is larger than 400 μm, there is no difference in the role of the two

Method used

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  • A porous scaffold with network channels and its preparation method
  • A porous scaffold with network channels and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Add 1.8g of β-TCP to 1.1g of 5% polyvinyl alcohol (PVA) aqueous solution, stir and grind, then add 0.45g of 380-550μm diameter paraffin balls and stir evenly, then pour into a mold with 0.054g of loofah (300μm in diameter) Molding, taking out the scaffold, standing at room temperature for 24 hours, putting it into a muffle furnace and heating to 1050°C for sintering, a porous scaffold with network channels is obtained. A three-dimensional porous scaffold with channels (300 μm in diameter) with a pore size of about 450 μm and a porosity of about 50% was obtained.

Embodiment 2

[0036] Example 2 Add 1.8g of hydroxyapatite to 1.1g of 5% PVA aqueous solution, stir, grind, then add 0.45g of 380-550μm diameter paraffin balls and stir evenly, then pour into a mold with 0.054g of loofah (300μm in diameter) and mold it, take it out The scaffold was placed at room temperature for 48 hours, put into a muffle furnace and heated to 1100°C for sintering, and a three-dimensional porous scaffold with a channel (diameter of 300 μm) with a pore diameter of about 450 μm and a porosity of about 50% was obtained.

Embodiment 3

[0037] Example 3 Add 1.8g of β-TCP to 0.54g of 10% PVA aqueous solution, stir, grind, then add 0.45g of 270-380μm diameter paraffin balls and stir evenly, then pour into a mold with 0.054g of loofah (300μm in diameter) and mold it, take out the bracket, Place it at room temperature for 24 hours, put it into a muffle furnace and heat it to 1050°C for sintering to obtain a three-dimensional porous scaffold with a channel (diameter of 300 μm) with a pore diameter of about 300 μm and a porosity of about 50%.

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Abstract

The invention belongs to the technical field of biomaterials and regenerative medicine, in particular to a porous support with network channels and a preparation method thereof. The matrix material of the porous support of the present invention can be inorganic materials such as ceramics, glass, carbon, etc., can also be a polymer material with self-bonding, solubility, and plasticity, and can also be a composite material of inorganic and polymer materials. The preparation method mixes the matrix material, the porogen and the network substance evenly. When the matrix material is an inorganic material, the porogen and the network substance are removed by high-temperature sintering; when the matrix material is a polymer material or a polymer material When compounding with inorganic materials, the porous scaffold with network channels is prepared by normal temperature molding / particle leaching method. The porous stent of the present invention builds a network channel structure on the three-dimensional space structure, which not only increases the connectivity between the pores of the stent, but also provides a favorable space for blood vessels to grow into the stent.

Description

technical field [0001] The invention belongs to the technical field of biomaterials and regenerative medicine, and in particular relates to a porous support with network channels and a preparation method thereof. Background technique [0002] Tissue engineering is the basic principle, basic theory, basic technology and basic method of comprehensive applied engineering and life science. The core of tissue engineering is to establish a three-dimensional complex of cells and scaffold materials, that is, a living tissue with vitality, which is used to reconstruct the shape, structure and function of the diseased tissue and achieve permanent replacement. Tissue induction does not introduce exogenous seed cells, but directly implants porous scaffolds to induce cell entry and even differentiation in the in vivo environment. Porous scaffolds play a key role in regenerative medicine research such as tissue engineering and tissue induction. It not only provides structural support for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02A61L27/12A61L27/26A61L27/18
Inventor 丁建东屈泽华
Owner FUDAN UNIV
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