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Preparation method of medicinal absolute ethyl alcohol

An anhydrous ethanol and water-containing ethanol technology, which is applied in the preparation of organic compounds, chemical instruments and methods, preparation of hydroxyl compounds, etc., can solve the problem of not considering the removal of trace impurities, and achieve good water removal effect, high purity, and preparation method. simple effect

Active Publication Date: 2012-05-02
CHINA NAT MEDICINES GUORUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] From the above-mentioned industrial ethanol and the preparation technology of chemical reagent absolute ethanol, it can be seen that while removing the moisture in the aqueous ethanol, the removal of trace impurities harmful to the human body in the medical absolute ethanol is not considered.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: The preparation method of the dehydrated alcohol that is used for medicine comprises the following steps:

[0039] (1) Take 10 L of 95% ethanol, add it to the still, heat and evaporate to above 120°C to obtain water-containing ethanol vapor, pass the water-containing ethanol vapor through a molecular sieve column, and the filler in the molecular sieve column is 50% each of 3A type molecular sieve and 4A type molecular sieve, Molecular sieve column diameter 20cm, length 65cm, obtain the absolute ethanol of the first stage;

[0040] (2) Add the anhydrous ethanol in the first stage into the reaction kettle, add 1.5kg of quicklime, heat and reflux for 2 hours, install a drying tube above the reflux condenser, the desiccant is block calcium chloride, and heat and reflux for 30-60 minutes Distill and collect the effluent at 78.5°C, which is the absolute ethanol in the second stage;

[0041] (3) Add the absolute ethanol in the second stage into the oxidation kettl...

Embodiment 2

[0044] Example 2: Check according to medicinal standards, three test results are as follows:

[0045] Ethanol content 99.80% 99.70% 99.70%

[0046] Water content 0.2% 0.15% 0.1%

[0047] Methanol content 150ppm 120ppm 180ppm

[0048] Esters content 3ppm 5ppm 2ppm

[0049]The above measurement results show that the absolute ethanol prepared by the method of the present invention meets the quality control requirements for the absolute ethanol used in medicine.

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Abstract

The invention discloses a preparation method of medicinal absolute ethyl alcohol. The method mainly comprises the following steps of: removing moisture from 95 percent ethanol by combining a physical method with a chemical method; treating absolute ethyl alcohol with a potassium permanganate oxidation process to remove methanol therein; removing ethyl acetate with an ordered mesoporous alumina adsorption method; and further rectifying by using a packing tower for removing water and methanol to finally obtain medicinal absolute ethyl alcohol. The preparation method is simple, and is suitable for the field of medicines; and physical adsorption and chemical reaction dehydration are adopted, so that a better water removing effect is achieved, and the purity of the obtained ethanol is high.

Description

technical field [0001] The invention relates to a method for purifying chemical substances, in particular to a method for preparing absolute ethanol used in medicine. Background technique [0002] Absolute ethanol for medicine is different from absolute ethanol for industrial use, and it is also different from absolute ethanol for chemical reagents (chemical pure or analytical pure, etc.). In addition to the content ≥ 99.5%, the limit of impurity content should be strictly limited, such as water ≤ 0.5%, methanol ≤ 0.2%, and ester ≤ 10ppm. [0003] Industrial dehydrated ethanol, chemical reagent The main technology for the preparation of dehydrated ethanol is to remove water, and other trace impurities are basically ignored, so the preparation method is only based on this principle. According to chemical monographs, chemical textbooks, chemical technology works and chemical and chemical literature reports, the main preparation methods of absolute ethanol are: [0004] (1) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C31/08C07C29/92C07C29/76C07C29/80
Inventor 金仁力王健蒋敏王震宇王效山
Owner CHINA NAT MEDICINES GUORUI PHARMA