Bioabsorbable polymeric compositions and medical devices

A technology of mixtures and copolymers, applied in medical science, surgery, etc.

Inactive Publication Date: 2012-05-16
ORBUSNEICH MEDICAL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] While the uses of bioabsorbable polymers are well known, it remains a challenge for biomedical scientists to develop effective bioabsorbable polymers for use in medical devices that withstand high pressures (exposed to stresses such as arterial constriction and blood flow). a huge challenge

Method used

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  • Bioabsorbable polymeric compositions and medical devices
  • Bioabsorbable polymeric compositions and medical devices
  • Bioabsorbable polymeric compositions and medical devices

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0168] Three batches of polymer blends were prepared. The composition of each batch is shown in Table I below.

[0169] Table I: Composition of batches of polymer expressed in weight percent

[0170]

[0171] 1. Poly-L-lactide

[0172] 2. Poly-D-lactide

[0173] 3. Poly-L-lactide-co-ε-caprolactone

[0174] 4. Poly-L-lactide-co-TMC

[0175] 5. Molar ratio L-lactide / ε-caprolactone: Note that these molar ratios represent nominal ratios only, that is, the standard error is ±5%

[0176] 6. Nominal molar ratio poly-L-lactide / TMC

[0177] 7. Nominal molar ratio poly-L-lactide / TMC

[0178] Differential Scanning Calorimetry (DSC) and Wide Angle Scattered X-ray Diffraction ("WAXS") were performed on each sample.

[0179] The polymer blend is extruded into long hollow tubes with varying wall thicknesses. In some cases, the tube is cut into small circles with a width of 1-2 mm. Prior to analysis, the tube or small ring is placed on an annealed mandrel with an outer diameter eq...

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Abstract

The present invention discloses a stent comprising a blend formed from a polymer. The polymer comprises poly-L-lactide, poly-D-lactide or mixtures thereof and a copolymer moiety comprising poly-L-lactide or poly-D-lactide linked with epsilon-caprolactone or trimethylcarbonate. The poly-L-lactide or poly-D-lactide sequence in the copolymer moiety is random with respect to the distribution of epsilon-caprolactone or trimethylcarbonate and the copolymer moiety molecular weight ranges from about 1.2 IV to about 4.8 IV. The polymere blend may have a wide-angle X-ray scattering (W AXS) 2-theta values of ranging from about 1 to about 35. The properties of the bioabsorbable polymers allow for both crimping and expansion of the stent. The crystal properties of the bioabsorbable polymers may change during crimping and / or expansion allowing for improved mechanical properties such as tensile strength and slower degradation kinetics.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of the following U.S. applications: U.S. Application Serial No.: 12 / 578,432 filed October 13, 2009, U.S. Application Serial No. 12 / 576,965 filed October 9, 2009, filed July 22, 2009 U.S. Application Serial No.: 12 / 507,663, U.S. Application Serial No.: 11 / 875,887, filed October 20, 2007, U.S. Application Serial No.: 11 / 875,892, filed October 20, 2007, U.S. Application Serial No., filed July 20, 2007 Application Serial No. 11 / 781,234 and US Application Serial No. 11 / 781,232, filed July 20, 2007, are hereby incorporated by reference in their entirety. This application also claims priority to US Provisional Application No. 61 / 178,878, filed May 15, 2009. Background technique [0003] While the uses of bioabsorbable polymers are well known, it remains a challenge for biomedical scientists to develop effective bioabsorbable polymers for use in medical devices that withstand high pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/32C08G63/91C08L71/00
CPCA61L31/14C08L67/04A61L31/041C08L2666/18
Inventor R・J・科顿
Owner ORBUSNEICH MEDICAL INC
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