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Novel application of sodium sulfite

A technology of sodium sulfite and disease, applied in the field of compounds, can solve problems such as useless pharmaceutical fields, and achieve the effect of improving the success rate and reducing the degree of bleeding

Inactive Publication Date: 2012-05-23
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Sodium sulfite has long been used as a chemical reagent and as a food additive, but not in pharmaceuticals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, sodium sulfite (Na 2 SO 3 ) Protective effect on high altitude hypoxic injury mice

[0025] Experimental animals: clean grade C57BL / 6J mice, male, 6-7 weeks old, weighing 18±2g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely. In this experiment, the mice were randomly divided into groups.

[0026] Sodium sulfite (Na 2 SO 3 ):Pharmaceutical Grade. Dissolved in 0.9% normal saline, ready for immediate use.

[0027] Administration method: Na 2 SO 3 The administration group was divided into three different concentrations according to 6.25, 12.5, and 25 mg / Kg body weight and given intraperitoneal injection for 3 consecutive days, and injected once a day. The acute plateau hypoxia experiment was started 4 hours after the last injection. The control group was the blank control group and physiological...

Embodiment 2

[0034] Embodiment 2, sodium sulfite (Na 2 SO 3 ) Protective effect on mice injured by hypoxia (mine operation) under atmospheric pressure

[0035] Experimental animals: clean grade C57BL / 6J mice, male, 6-7 weeks old, weighing 18±2g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely. In this experiment, the mice were randomly divided into groups.

[0036] Sodium sulfite (Na 2 SO 3 ):Pharmaceutical Grade. Dissolved in 0.9% normal saline, ready for immediate use.

[0037] Administration method: Na 2 SO 3 The administration group was divided into three different concentrations according to 6.25, 12.5, 25mg / Kg body weight and given intraperitoneal injection, Na 2 SO 3 The intraperitoneal injection was performed once a day for 3 consecutive days, and the acute normal-pressure hypoxia experiment was started 4 hours after...

Embodiment 3

[0044] Embodiment 3: sodium sulfite (Na 2 SO 3 ) Protective effect on ischemic hypoxic injury mice

[0045] Experimental animals: clean grade C57BL / 6J mice, male, 6-7 weeks old, weighing 18±2g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely.

[0046] In this experiment, the mice were randomly divided into groups.

[0047] Sodium sulfite (Na 2 SO 3 ):Pharmaceutical Grade. Dissolved in 0.9% normal saline, ready for immediate use.

[0048] Administration method: Na 2 SO 3 The administration group was divided into three different concentrations according to 6.25, 12.5, and 25 mg / Kg body weight and given intraperitoneal injection for 3 consecutive days, and injected once a day. The ischemic hypoxic injury experiment was started 4 hours after the last injection. The middle cerebral artery infarction (MCAO) model was p...

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Abstract

The invention discloses a novel application of sodium sulfite (Na2SO3), that is, an application in preparing medicines, health products, functional drinks or functional food for preventing hypoxia-induced injury and / or diseases related to ischemia-hypoxia. According to the invention, by using Na2SO3 as an active component in preparing medicines, health products, functional drinks or functional food for preventing hypoxia-induced injury and / or diseases related to ischemia-hypoxia, the body can be in a hypoxia (such as high altitude hypoxia, mine hypoxia, and the like ) preconditioning state, thus the purpose of preventing hypoxia-induced injury and / or diseases related to ischemia-hypoxia (such as high altitude pulmonary edema, high altitude cerebral edema, cerebral ischemia, cardiac ischemia, respiratory distress, and the like) can be achieved. The medicines disclosed herein have the following advantages: 1) obvious curative effect; 2) no toxic and side effect, and high safety; 3) low price of Na2SO3; and 4) convenience in drug use (convenience in carrying and taking).

Description

technical field [0001] The present invention belongs to the new application of compounds, in particular to the application of sodium sulfite in the preparation of medicines and / or health care products for preventing hypoxic injury and / or ischemic hypoxic related diseases. Background technique [0002] Oxygen is the basis of life activities of living organisms. Relatively closed spaces such as plateaus and mines, as well as factors such as vascular blockage and blood circulation disorders can cause hypoxia to varying degrees. Hypoxia can not only change the physiological functions of living organisms, but also cause a series of injuries and diseases in severe cases. For example, cerebral ischemia and hypoxia can cause stroke and nervous system degenerative diseases, while the heart, liver and kidneys and other organs Long-term hypoxia in the mountains can also cause organ damage. At the same time, high-altitude hypoxia can easily cause diseases such as high-altitude cerebral ...

Claims

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Application Information

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IPC IPC(8): A61K33/04A21D2/02A23L1/29A23L1/30A23L1/302A23L1/308A23L2/38A61P9/10A61P11/00A23L33/00A23L33/15
Inventor 张成岗李伟光何国维高艳蒋斌李志慧吴永红
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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