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Preparation method of traditional Chinese medicinal composition for treating primary hypertension

A technology of essential hypertension and composition, which is applied in the field of medicine to achieve the effects of small side effects, definite curative effect and low price

Inactive Publication Date: 2015-04-01
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are not many proprietary Chinese medicines for essential hypertension caused by anti-metabolic syndrome on the market. , and some discontinued use during the application process due to inaccurate curative effect

Method used

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  • Preparation method of traditional Chinese medicinal composition for treating primary hypertension
  • Preparation method of traditional Chinese medicinal composition for treating primary hypertension
  • Preparation method of traditional Chinese medicinal composition for treating primary hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Embodiment 1, pharmaceutical composition (CT-1) of the present invention

[0152] 6 parts of wine rhubarb, 15 parts of turmeric, 30 parts of cassia seeds

[0153] 30 parts of Uncaria, 30 parts of A. chinensis, 45 parts of Prunella vulgaris

[0154] 30 parts of earthworm, 6 parts of red yeast rice

[0155] Uncaria is soaked in cold water alone (150mL / prescription), and the remaining herbs are soaked in cold water for 20 minutes (700mL / prescription), heated to boiling, and then simmered for 20 minutes. The medicinal materials and decoction liquid are combined with Uncaria and its soaking liquid, boiled with strong fire, decocted with slow fire for 5 minutes, poured out the medicinal liquid, and concentrated to dryness under reduced pressure at 60-65°C.

Embodiment 2

[0156] Embodiment 2, pharmaceutical composition (CT-5) of the present invention

[0157] 6 parts of wine rhubarb, 15 parts of turmeric, 30 parts of cassia seeds

[0158] 30 parts of Uncaria, 30 parts of A. chinensis, 45 parts of Prunella vulgaris

[0159] 30 parts of earthworm, 6 parts of red yeast rice

[0160] Add 8 times of water to soak the whole recipe for 0.5h, heat to boiling, extract for 1h, filter, add 7 times of water to decoct the medicinal residues for 1h, filter, discard the medicinal residues, combine the two extracts, and depressurize at 60-65°C Concentrate to D60=1.05-1.10 to obtain a concentrated solution. After cooling to room temperature, add 95% ethanol to precipitate, and stir while adding, until the supernatant contains 70% alcohol, let stand for 12h, filter, discard the precipitate, and filtrate 60 Concentrate to dryness at ~65°C under reduced pressure.

[0161] The active substance obtained by the above process is mixed with a pharmaceutically accept...

Embodiment 3

[0162] Embodiment 3 pharmaceutical composition (ZY-1) of the present invention

[0163] 6 parts of wine rhubarb, 15 parts of turmeric, 30 parts of cassia seeds

[0164] 30 parts of Uncaria, 30 parts of A. chinensis, 45 parts of Prunella vulgaris

[0165] 30 parts of earthworm, 6 parts of red yeast rice

[0166] Add 8 times of 50% ethanol to wine rhubarb, extract for 1 hour, filter, add 8 times of 50% ethanol to the medicinal residues, extract for 1 hour, filter, discard the medicinal residues, combine the extracts, concentrate under reduced pressure at 60-65°C to 4 times the volume of the medicinal materials , add water and dilute to 15 times the volume of the medicinal material, let stand for 12h, centrifuge to get the supernatant, D101 purification (1.5 times the amount of medicinal material), load the sample, wash with water (5 column volumes), 80% ethanol elution (7 column volumes) volume), and the eluate was concentrated to dryness under reduced pressure at 60-65°C.

...

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Abstract

The invention relates to a preparation method of a traditional Chinese medicinal composition for treating primary hypertension. The preparation method of the composition comprises the following steps of: adding ethanol into rhubarb stir-fried with wine for extraction, filtering, adding ethanol into herb residue for extraction, filtering, removing the herb residue, margining the extracts, condensing, adding water for dilution, followed by centrifugation, taking a supernatant, purifying, loading, washing by water, carrying out elution by ethanol, condensing the eluate until it is dry, adding ethanol into Rhizoma Coptidis for extraction, filtering, adding ethanol into herb residue for extraction, filtering, removing the herb residue, merging extracts, condensing, cooling to room temperature, adjusting pH by the addition of hydrochloric acid, filtering, removing a filtrate, taking the precipitate part, drying, immersing other medicines excluding rhubarb stir-fried with wine and Rhizoma Coptidis by the addition of water, heating to boiling, extracting, filtering, adding water into herb residue and decocting, filtering, removing the herb residue, merging extracts, condensing to obtain a concentrate, cooling to room temperature, adding ethanol for alcohol precipitation while stirring, standing, filtering, removing a precipitate, condensing a filtrate until it is dry, and mixing the above three dry powders according to the proportion of a prescription.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating essential hypertension and a preparation method thereof. Background technique [0002] Diseases of modern civilization represented by metabolic syndrome are closely related to some modern lifestyles and habits. It is a high-risk factor for type 2 diabetes and cardiovascular disease. Early diagnosis and early intervention of metabolic syndrome are helpful for the prevention and treatment of type 2 diabetes and cardiovascular disease. [0003] The definition of metabolic syndrome centers on central obesity with elevated blood pressure, blood glucose, triglycerides, and / or low HDL-C. Among them, waist circumference is used as a diagnostic index for central obesity. [0004] Hypertension is a clinical syndrome mainly manifested by increased systemic arterial pressure. It is the most common cardiovascular disease and can be divided int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61P9/12A61K35/62
Inventor 张兰兰周水平宋兆辉李欣欣蔡楠黄芝娟仝小林朱永宏
Owner TIANJIN TASLY PHARMA CO LTD