Nanometer gamma-ferric oxide/ polyaniline- chlorambucil and preparation method

The technology of chlorambucil and iron oxide is applied in the directions of electrotherapy, pharmaceutical formulations, and medical preparations of inactive ingredients, etc., and can solve the problems of poor specificity, chemical instability and high toxicity of chlorambucil, To achieve the best therapeutic effect, reduce toxic and side effects, good electrical conductivity

Inactive Publication Date: 2012-06-13
YANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the poor specificity, high toxicity and chemical instability of chlorambucil, its application is greatly limited.

Method used

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  • Nanometer gamma-ferric oxide/ polyaniline- chlorambucil and preparation method
  • Nanometer gamma-ferric oxide/ polyaniline- chlorambucil and preparation method
  • Nanometer gamma-ferric oxide/ polyaniline- chlorambucil and preparation method

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Embodiment

[0042] 1. Raw materials: aniline (distilled under reduced pressure to colorless and stored in a 4°C refrigerator for later use), hydrochloric acid, sulfuric acid, camphorsulfonic acid, ammonia water, sodium hydroxide, sodium carbonate, ammonium persulfate, γ-iron oxide, benzene Drugs such as butyric acid mustard are of analytical grade, and the solutions are all prepared with twice distilled water.

[0043] 2. Preparation of γ-iron oxide / polyaniline: the same concentration of 0.1mol L -1 Mix the above aniline with hydrochloric acid solution, add more than 0.1g of gamma-iron oxide into the above mixed solution, stir, slowly add ammonium persulfate with aniline molar ratio not less than 1:1 in the process, continue to stir Less than 2 hours, suction filtration, vacuum drying. Afterwards, soak the product with ethanol, acetone, etc. and suction-filter until the filtrate is colorless, and wash with secondary water. Then use a concentration higher than 0.1mol·L-1 The ammonia wate...

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Abstract

The invention relates to nanometer gamma-ferric oxide / polyaniline- chlorambucil and a preparation method. Aniline and hydrochloric acid solution are mixed, are stirred after being added with gamma-ferric oxide, then are added with ammonium persulfate, are stirred, filtered in a suction manner and dried in a vacuum manner, and are soaked and washed by ethanol or / and acetone, impurities of polyaniline are removed by ammonia water, so that eigenstate gamma-ferric oxide / polyaniline is obtained, undoped gamma-ferric oxide / polyaniline is obtained after vacuum drying, the undoped gamma-ferric oxide / polyaniline and chlorambucil are added into aqueous solution via different ratio of amounts of substances, are stirred, and are filtered in a vacuum pressure-reduction suction manner, products are washed by water or / and ethanol or acetone, and are placed in various protonic acid solution to be stirred, filtered, washed and dried again, so that the final product, namely superparamagnetism conductive nanometer gamma-ferric oxide / polyaniline-chlorambucil is obtained. The nanometer gamma-ferric oxide / polyaniline- chlorambucil and the preparation method overcome shortcomings that chlorambucil is poor in specificity, high in toxicity and the like. Recognition ability to lesion tissues when the nanometer gamma-ferric oxide / polyaniline- chlorambucil is electrically stimulated by cell walls is improved, and toxic and side effects to normal tissues are achieved.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to nanometer gamma-iron oxide / polyaniline-chlorambucil and a preparation method thereof. Background technique [0002] In order to improve the chemotherapy effect of cancer patients, modern biotechnology represented by genetic engineering, cell engineering, enzyme engineering, fermentation engineering and nanotechnology has developed rapidly in the past ten years. However, how to use drug carriers with special recognition ability to cancerous tissues to increase the concentration of chemotherapy drugs in cancerous tissues, improve the in vivo kinetic properties of drugs, and reduce the toxic and side effects of drugs has always been an unsolved problem and research hotspot at home and abroad. Betancourt in the United States proposed the idea of ​​improving the drug delivery system in the body to increase the effect of chemotherapy. The Park Research Group in South Korea s...

Claims

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Application Information

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IPC IPC(8): A61K50/00A61K47/48A61K31/196A61P35/00C08G73/02C08L79/02C08K3/22C08K5/18
Inventor 阚锦晴郎建平
Owner YANGZHOU UNIV
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