Method for preparing magnetic resonance contrast medium in microminiature and superparamagnetism

A magnetic resonance contrast agent and superparamagnetic technology, applied in the nano field, can solve the problems of poor dispersion effect, high cost, particle agglomeration, etc., and achieve the effects of good safety, cost reduction and high efficiency

Inactive Publication Date: 2005-01-12
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

From the point of view of the preparation process, this method adopts centrifugal separation, which is costly and wasteful; from the published results, the dispersion effect is not good, the particle size is relatively large, generally above 20nm, and many particles are agglomerated together The phenomenon
[0005] In conclusion, the current methods for preparing ultra-small superparamagnetic magnetic resonance contrast agents at home and abroad have problems such as wide particle size steps, high cost, and poor imaging effects.

Method used

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  • Method for preparing magnetic resonance contrast medium in microminiature and superparamagnetism
  • Method for preparing magnetic resonance contrast medium in microminiature and superparamagnetism
  • Method for preparing magnetic resonance contrast medium in microminiature and superparamagnetism

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Embodiment 1

[0024] 10 grams of dextran with a molecular weight of 20,000 was mixed with 2.34 grams of ferric chloride and 0.86 grams of ferrous chloride to form an aqueous solution. At a temperature of 5 ° C and a mechanical stirring speed of 1500 rpm, 30 ml of dextran was gradually added dropwise at 5 ° C. The concentration is 28% ammonia water, after the ammonia water is added dropwise, the temperature is heated to 80° C. within 30 minutes, and the stirring is continued, and the temperature is controlled at 80° C. for about 1 hour. After cooling, dilute hydrochloric acid was added to adjust the pH to 7.4-7.6, and then phosphate buffer (ie PBS) was added to maintain the pH of the buffer system. Sterilize by filtration, add 50% glucose solution, and store at 4°C.

Embodiment 2

[0026] 15 grams of dextran with a molecular weight of 20,000 are mixed with 2.34 grams of ferric chloride and 0.86 gram of ferrous chloride to form an aqueous solution. At a temperature of 5 ° C and a mechanical stirring speed of 1500 rpm, 30 ml of dextran is gradually added dropwise at 5 ° C The concentration is 28% ammonia water, after the ammonia water is added dropwise, the temperature is heated to 80° C. within 30 minutes, and the stirring is continued, and the temperature is controlled at 80° C. for about 1 hour. After cooling, dilute hydrochloric acid was added to adjust the pH to 7.4-7.6, and then phosphate buffer (ie PBS) was added to maintain the pH of the buffer system. Sterilize by filtration, add 50% glucose solution, and store at 10°C.

Embodiment 3

[0028] 25 grams of dextran with a molecular weight of 20,000 are mixed with 2.34 grams of ferric chloride and 0.86 grams of ferrous chloride to form an aqueous solution. At a temperature of 5 ° C and a mechanical stirring speed of 1500 rpm, 30 ml of dextran is gradually added dropwise at 5 ° C. The concentration is 30% ammonia water, after the ammonia water is added dropwise, the temperature is heated to 80°C within 30 minutes, and the stirring is continued, and the temperature is controlled at 80°C for about 1 hour. After cooling, dilute hydrochloric acid was added to adjust the pH to 7.4-7.6, and then phosphate buffer (ie PBS) was added to maintain the pH of the buffer system. Sterilize by filtration, add 50% glucose solution, and store at 10°C.

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Abstract

A process for preparing the superfine ultra-paramagnetic contrast medium for magnetic resonance includes such steps as dropping the ammonia solution into the mixed solution of Fe salt, ferrous salt and polyose at 4-7 deg.C under N2 protection to make pH=9.5-10 while stirring, raising its temp to 60-90 deg.C, holding the temp for 50-70 min while stirring, cooling, adding diluted hydrochloric acid to make pH=7.4-7.6, adding PBS, filtering, adding solution of glucose, and storing at 4-15 deg.C.

Description

technical field [0001] The invention belongs to nanotechnology, and in particular relates to a method for preparing an ultra-small superparamagnetic magnetic resonance contrast agent. Background technique [0002] Magnetic resonance contrast agent is used in magnetic resonance imaging technology to improve the imaging contrast, so that the original tissue structure that lacks contrast difference can be displayed more clearly, so as to better display the structure of tissues and organs in the body, the nature and functional state of lesions, and can greatly improve the quality of life. Accurate and early diagnosis. [0003] At present, the commonly used magnetic resonance contrast agent is gadolinium diethylenediamine acetate, but the distribution of this contrast agent in the body is non-specific, and it quickly enters the intercellular space after entering the blood. To maintain a sufficient concentration during the imaging time, a large dose needs to be injected. Moreover...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
Inventor 刘祖黎胡道予杜玉卿李震杜桂焕褚倩卢强华孙素静
Owner HUAZHONG UNIV OF SCI & TECH
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