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Production method of high-purity piperine

A production method and technology of piperine, which is applied in the field of high-purity piperine production, can solve the problems of poor piperine solubility, less research on piperine components, and low extraction rate, and achieve simple and easy purification process, less impurities, The effect of high extraction rate

Active Publication Date: 2012-06-20
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Supercritical CO 2 The fluid has good solubility to pepper essential oil and non-volatile oil substances, and the extraction rate is high, but the solubility to piperine is poor, and the extraction rate is low. At present, supercritical CO 2 The extraction equipment is mainly used to extract the essential oil of pepper, but there is less research on the components of piperine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: The production method of this high-purity piperine adopts following processing steps.

[0018] 1. Tablet processing: the pepper raw material is processed by tabletting to obtain 80 kg of pepper sheets with a thickness of 0.5 mm.

[0019] 2. Extraction of pepper essential oil: pepper pressed into supercritical CO 2 Extraction in the extraction tank, extraction pressure 12MPa, extraction temperature 40°C, CO 2 The flow rate is 1100L / h, and the extraction time is 3 hours; the fluid with the extract enters the separation tank for separation, the separation pressure is 9MPa, and the separation temperature is 35°C to collect pepper essential oil and small molecular impurities.

[0020] 3. Extraction of pepper oleoresin: supercritical CO 2 The pepper flakes after extracting pepper essential oil in the extraction kettle were extracted at an extraction pressure of 27MPa and an extraction temperature of 65°C. CO 2 The flow rate is 1500L / h, and the extraction time...

Embodiment 2

[0022] Embodiment 2: The production method of this high-purity piperine adopts following processing steps.

[0023] 1. Tablet processing: Pepper raw materials are processed by tabletting to obtain 82 kg of pepper sheets with a thickness of 0.3 mm.

[0024] 2. Extraction of pepper essential oil: pepper pressed into supercritical CO 2 Extraction in the extraction tank, extraction pressure 15MPa, extraction temperature 45°C, CO 2 The flow rate is 1200L / h, the extraction time is 2.0 hours; the fluid with the extract enters the separation tank for separation, the separation pressure is 10MPa, and the separation temperature is 40°C to collect pepper essential oil.

[0025] 3. Extraction of pepper oleoresin: supercritical CO 2 The pepper flakes after extracting pepper essential oil in the extraction kettle were extracted at an extraction pressure of 29MPa and an extraction temperature of 60°C. CO 2 The flow rate is 1550L / h, and the extraction time is 2.0h; during the extraction pr...

Embodiment 3

[0027] Embodiment 3: The production method of this high-purity piperine adopts following processing steps.

[0028] 1. Tablet processing: Pepper raw materials are processed by tabletting to obtain 80 kg of pepper sheets with a thickness of 0.1 mm.

[0029] 2. Extraction of pepper essential oil: pepper pressed into supercritical CO 2 Extraction in the extraction tank, extraction pressure 10MPa, extraction temperature 35°C, CO 2 The flow rate is 1150L / h, and the extraction time is 2.5 hours; the fluid with the extract enters the separation tank for separation, the separation pressure is 7MPa, and the separation temperature is 32°C to collect pepper essential oil and small molecular impurities.

[0030] 3. Extraction of pepper oleoresin: supercritical CO 2 The pepper flakes after the pepper essential oil is extracted in the extraction kettle are extracted at an extraction pressure of 30MPa and an extraction temperature of 80°C. CO 2 The flow rate is 1400L / h, and the extraction...

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Abstract

The invention discloses a production method of high-purity piperine. The production method comprises the following steps: firstly extracting pepper essential oil from a pepper raw material through a supercritical CO2 fluid; then extracting pepper oil resin through the supercritical CO2 fluid, wherein a mixed solvent of ethanol and water is taken as an entrainer during the extraction process; and mixing the pepper oil resin obtained by supercritical extraction with edible oil for purifying the piperine, and purifying through edible alcohol and denatured alcohol to get the high-purity piperine. The method is as follows: firstly extracting the pepper essential oil; and then extracting a pepper oil resin component by adopting the mixed solvent of the ethanol and the water as the entrainer, then mixing the pepper oil resin with the edible oil for purifying the piperine, and finally purifying through the denatured alcohol and the edible alcohol to get the high-purity piperine. The method adopts a physical method for extraction, the extraction rate is high, impurities are few, a purification process is simple and easy to operate, and an obtained piperine product is high in purity, good in quality and high in added value, and has pure natural feature.

Description

technical field [0001] The invention relates to extraction and purification of pepper, in particular to a production method of high-purity piperine. Background technique [0002] Piperine is an active ingredient of black or white pepper of the piperaceae plant. It has unique curative effects such as analgesia, warming the middle and dispelling cold, appetizing and lowering qi, anti-inflammatory and detoxification. It is a necessary intermediate or additive for many drugs in the pharmaceutical industry. The application value cannot be underestimated. At present, the process of extracting piperine from pepper mostly adopts the process of solvent extraction and crystallization separation. This method extracts impurities such as essential oils, oleoresins, pigments, proteins, sugars, etc. in the raw materials. During the purification process, degreasing, Decolorization, impurity removal and other treatments, the process is complicated and a large amount of essential oils and re...

Claims

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Application Information

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IPC IPC(8): C07D317/60
CPCY02P20/54
Inventor 李凤飞杨文江孙国峰
Owner CHENGUANG BIOTECH GRP CO LTD
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