Method for synthesizing calcium polycarbophil

A technology of polycarbophil calcium and its synthesis method, which is applied in the field of pharmaceutical preparation, and can solve the problems of inaccurate control of factors such as reaction time and temperature, low calcium content, and low yield of polycarbophil calcium products, etc.

Active Publication Date: 2012-06-27
ZHEJIANG TOP MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The conventional method for synthesizing polycarbophil calcium, due to inaccurate control of factors such as reaction time and temperature of polycarbophil calcium synthesis, often causes the product yield of polycarbophil calcium to be low, and the calcium in the product quality item lower content

Method used

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Embodiment Construction

[0008] The preferred embodiment of the synthetic method of a kind of polycarbophil calcium of the present invention is described in detail below:

[0009] A synthetic method for polycarbophil calcium, comprising the following steps:

[0010] ①Firstly, fully dissolve magnesium sulfate and divinyl glycol in water in a stirred reactor, and heat up to 76°C while stirring to fully dissolve;

[0011] ②Then add the mixture of acrylic acid and azobisisobutyronitrile dropwise, stir evenly, and keep warm for 3 hours;

[0012] ③ wash with 76 DEG C of clear water to obtain the magnesium salt of polycarbophil;

[0013] ④ Fully stir the aqueous solution of magnesium salt of polycarbophil and calcium carbonate in the reaction kettle, and simultaneously raise the temperature to 100°C for 6.5 hours;

[0014] ⑤Put it down for centrifugal dehydration, dry, pulverize, and pack the finished product if it passes the inspection.

[0015] Using the polycarbophil calcium synthesized by the above me...

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PUM

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Abstract

The invention relates to a method for preparing drugs, in particular to a method for synthesizing calcium polycarbophil. The method for synthesizing calcium polycarbophil comprises the following steps of: 1) fully dissolving magnesium sulfate and divinyl glycol in water, increasing the temperature to 76 DEG C; 2) dropwise adding mixed liquor of crylic acid and azodiisobutyronitrile, and reacting for 3 hours under a temperature-keeping condition; 3) washing with clean water at 76 DEG C, thereby obtaining magnesium polycarbophil; 4) fully stirring the magnesium polycarbophil and the aqueous solution of calcium carbonate, increasing the temperature to 100 DEG C, and reacting for 6.5 hours; and 5) putting down, centrifuging, drying and crushing, thereby obtaining the end product. The reaction time and the temperature control are reasonable, so that the yield of the end product of the calcium polycarbophil is close to 100%, the content of calcium in mass item reaches 22%, and the method is obviously progressed, compared with the conventional synthesizing method.

Description

[0001] technical field [0002] The invention relates to a method for preparing medicines, in particular to a method for synthesizing polycarbophil calcium. Background technique [0003] Polycarbophil calcium, as a special macromolecule, has dual functions of treating constipation and diarrhea. Because polycarbophil calcium is a kind of prodrug again, the active ingredient that plays a role is polycarbophil, and under the effect of stomach acid, polycarbophil calcium takes place the ion exchange reaction of decalcification, generates by-product calcium, therefore polycarbophil calcium Calcium carbofil has the unique advantage of calcium supplementation during treatment. [0004] The conventional method for synthesizing polycarbophil calcium, due to inaccurate control of factors such as reaction time and temperature of polycarbophil calcium synthesis, often causes the product yield of polycarbophil calcium to be low, and the calcium in the product quality item The content i...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F8/44
Inventor 姚凤鸣谢再法
Owner ZHEJIANG TOP MEDICINE
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