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Loxoprofen sodium gel

A technology of loxoprofen sodium and gel, which is applied in the field of pharmaceutical preparations, can solve the problems of difficulty in forming a transdermal drug delivery preparation with stable curative effect, poor drug permeability of loxoprofen sodium, etc., so as to improve the therapeutic effect and Onset time, effect of enhancing transmittance

Inactive Publication Date: 2012-07-04
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Loxoprofen sodium drug itself has poor percutaneous permeability, and it is difficult to form a stable transdermal preparation of curative effect. Therefore, by an appropriate method, preparing a fast-acting loxoprofen sodium transdermal preparation is an important aspect of the present invention. The problem to be solved by the invention

Method used

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  • Loxoprofen sodium gel
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Experimental program
Comparison scheme
Effect test

Embodiment 1-11

[0023] The prescription of table 1 embodiment 1-11

[0024]

[0025] Preparation method 1: feed intake according to the prescription quantity in table 1, get the loxoprofen sodium of the prescription quantity, transdermal enhancer and dissolve in ethanol, add water and stir well, add gel matrix swelling overnight under stirring state, wait for The paste is uniform and transparent, and can be divided into two packages.

[0026] Preparation method 2: Feed according to the prescription amount in Table 1, take the loxoprofen sodium of the prescription amount, dissolve it in ethanol, add water and stir well, add gel matrix under stirring state to swell overnight, then add transdermal promoting Stir the agent evenly until the paste is uniform and transparent to obtain a gel, which can be obtained by sub-packaging.

[0027] Preparation method 3: feed intake according to the prescription quantity in Table 1, take the prescription quantity of loxoprofen sodium, transdermal accelera...

Embodiment 12-23

[0029] The prescription of table 2 embodiment 12-23

[0030]

[0031] Preparation method 1: Feed according to the prescription amount in Table 2, take the preservative, loxoprofen sodium, and skin penetration enhancer of the prescription amount and dissolve them in ethanol, add water and stir well, add gel matrix under stirring state to swell Leave overnight, until the paste is uniform and transparent, then pack it separately.

[0032] Preparation method 2: Feed according to the prescription amount in Table 2, take the preservative of the prescription amount, loxoprofen sodium, dissolve in ethanol, add water and stir well, add the gel matrix under stirring state to swell overnight, then add Stir the skin penetration enhancer evenly until the paste is uniform and transparent to obtain a gel, which can be obtained by sub-packaging.

[0033] Preparation method 3: feed intake according to the prescription quantity in Table 2, take the preservative, loxoprofen sodium, transderm...

Embodiment 24-30

[0035] The prescription of table 3 embodiment 12-22

[0036]

[0037] Preparation method 1: Feed according to the prescription quantity in Table 3, take the prescription quantity of antiseptic, loxoprofen sodium, transdermal enhancer and dissolve it in ethanol, add water and stir well, add gel matrix under stirring state to swell Overnight, if the gel base is carbomer or contains carbomer, you need to use triethanolamine to adjust the pH value to 5-7, and when the paste is uniform and transparent, divide it and get it.

[0038]Preparation method 2: feed intake according to the prescription quantity in Table 3, take the preservative of prescription quantity, loxoprofen sodium, dissolve in ethanol, add water and stir well, add gel matrix under stirring state to swell overnight, if gel If the gel base is carbomer or contains carbomer, it is necessary to adjust the pH value to 5-7 with triethanolamine, then add a transdermal accelerator and stir evenly until the paste is unifor...

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Abstract

The invention relates to loxoprofen sodium gel, which comprises the following components in percentage by weight: 0.1-5.0 percent of loxoprofen sodium, 0.05-25.0 percent of a penetration enhancer, 0.5-8.0 percent of a gel substrate and 65-95 percent of a solvent, wherein the penetration enhancer is selected from azone, oleic acid or a mixture of azone and propylene glycol or / and oleic acid or a mixture of propylene glycol and oleic acid. Due to the adoption of the gel, the endermic permeation amount of loxoprofen sodium can be increased greatly; and the formed gel is uniform and transparent, and is used for treating swelling and pain caused by arthritis deformans and trauma.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a loxoprofen sodium gel composition and application thereof. The composition can greatly increase the transdermal penetration of loxoprofen sodium, and the formed gel is uniform , transparent, the composition preparation is used for the treatment of osteoarthritis, swelling and pain caused by trauma. Background technique [0002] Loxoprofen sodium is the first chemically synthesized precursor non-steroidal anti-inflammatory drug synthesized and developed by Japan Sankyo Company, belonging to the phenylpropionic acid class. As a non-steroidal anti-inflammatory analgesic based on phenylpropionic acid, it has excellent efficacy and is widely used in oral medicine. Its trade name is "Loxonin". The structural formula of loxoprofen sodium is as follows: [0003] [0004] Loxoprofen sodium is mainly used for osteoarthritis, local swelling and pain treatment ca...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/192A61K47/10A61K47/12A61K47/22A61K47/32A61K47/38A61P19/02A61P29/00
Inventor 丁彦吉张涛樊斌邓杰
Owner CHONGQING PHARMA RES INST
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