Transdermal absorption medicament used for skins and comprising adjuvant-containing methylprednisolone aceponate and adjuvant-containing water

A technology of methylprednisolone acetonide and pharmaceutical excipients is applied in the directions of medical preparations containing active ingredients, skin diseases, drug combinations, etc., which can solve the problem of particle instability and inability to guarantee the Ostwald ripening of microparticle suspensions. and other problems to achieve the effect of reducing waste and ensuring suspension stability

Inactive Publication Date: 2012-07-11
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems to be solved in pharmacy, but no matter whether by adding excipients or improving the particle structure, there is no guarantee that microparticle suspensions will not appear Osmos during storage. Twald ripening, especially with multiple uses of dermal suspensions, is more likely to occur

Method used

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  • Transdermal absorption medicament used for skins and comprising adjuvant-containing methylprednisolone aceponate and adjuvant-containing water
  • Transdermal absorption medicament used for skins and comprising adjuvant-containing methylprednisolone aceponate and adjuvant-containing water
  • Transdermal absorption medicament used for skins and comprising adjuvant-containing methylprednisolone aceponate and adjuvant-containing water

Examples

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preparation example Construction

[0039] 1. Preparation of drug particles for transdermal absorption

[0040] The capsules packed with the drug microparticles obtained in Examples 1 to 10 are plant capsules, and the capsules are sealed and packaged with aluminum foil blisters after packing. The water containing auxiliary materials obtained in Examples 11 and 12 is sealed and packed in ampoules.

Embodiment 1

[0042] Dissolve 0.2g of methylprednisolone acetin in ethanol, filter, sterilize, spray-dry the filtrate, micronize the particle size to 3 μm, mix it with 1.5 g of crystalline lactose with a particle size of 30 μm, and pass it through a 200-mesh sieve for 3 times After mixing, divide into No. 2 capsules, and each capsule contains 2 mg of methylprednisolone acetone. Electron microscope observation shows that the drug particles are spherical.

[0043] The process conditions are: the inlet temperature is 100°C, the outlet temperature is 70°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0045] Dissolve 1 g of methylprednisolone acetin in ethanol, filter, spray dry the filtrate, micronize the particle size to 3 μm, mix it with 15 g of crystalline lactose with a particle size of 30 μm, mix it with a 200-mesh sieve for 3 times, and then sterilize , divided into No. 2 capsules, and each capsule contains 1 mg of methylprednisolone acetone. Electron microscope observation shows that the particles are spherical.

[0046] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

The invention relates to a transdermal absorption medicament used for skins and comprising adjuvant-containing methylprednisolone aceponate and adjuvant-containing water. The medicament comprises individually packaged methylprednisolone aceponate which contains one or several solid pharmaceutic adjuvants, is insoluble in water and has D90 particle sizes of 0.1-10mum, and individually packaged water containing one or several pharmaceutic adjuvants soluble in water.

Description

Technical field: [0001] The invention relates to a medicine for skin, which is composed of separately packaged one or several skin medicine auxiliary materials and methylprednisolone acetate and water containing the auxiliary materials in the separate package. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by allergic reactions caused by certain allergens. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs with higher solubility cross the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transdermal drug delivery system (transdermal thrapeutic systems, transderm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/10A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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