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Hemostatic dressing and production method thereof

A hemostatic dressing and a production method technology, applied in the field of hemostatic dressing and its production, can solve the problems of increased platelet aggregation and coagulation factor concentration time, large particle size, unsatisfactory hemostatic effect, etc. Rapid and reliable effect of tissue and hemostasis

Active Publication Date: 2014-07-23
ZHUHAI HEFAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary powder medicines have large particle size, large number of atoms in the particles, and few atoms distributed on the surface. When the ordinary powder medicine dressing is directly applied to the wound, it will not selectively absorb water molecules in the blood, and will Absorb other components in the blood, which will greatly increase the concentration time of platelet aggregation and coagulation factors, and its hemostatic effect is not very ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A hemostatic dressing, which includes cuttlefish made into nano-level powder.

[0022] The manufacturing method of the above hemostatic dressing includes the following steps:

[0023] Step one, first wash the cuttlefish, and use tap water to remove the impurities and soil on the cuttlefish;

[0024] Step 2: Wash the cuttlefish finely, and soak and clean the cuttlefish with deionized water;

[0025] Step 3: Dry the washed cuttlefish with hot air at 80℃-100℃;

[0026] Step 4: Use mechanical ball milling or jet pulverization to crush the dried cuttlefish until the cuttlefish powder has a diameter of 30-50 microns;

[0027] Step 5: Seal the cuttlefish powder in a plastic film or aluminum foil that can permeate ethylene oxide, package it at 50g / bag or 100g / bag, and put it in a medium epoxy sterilizer for sterilization, or use Cobalt 60 irradiation for sterilization, where the concentration of ethylene oxide is 800MG-1000MG / L, the temperature is 55℃-60℃, the relative humidity is 60-80%...

Embodiment 2

[0030] A hemostatic dressing, which includes cuttlefish made into nano-level powder and Bletilla striata made into nano-level powder, wherein the weight component ratio of cuttlefish and Bletilla striata is: cuttlefish 1-10 parts, Bletilla striata 1- 10 servings. The best weight component ratio of cuttlefish and Bletilla striata is: 1 part of cuttlefish and 1 part of Bletilla striata.

[0031] The manufacturing method of the above hemostatic dressing includes the following steps:

[0032] Step one, first wash the cuttlefish and Bletilla striata, and use tap water to remove the impurities and soil on the cuttlefish and Bletilla striata;

[0033] Step 2: Wash the cuttlefish and Bletilla striata with deionized water to soak and clean the cuttlefish and Bletilla striata;

[0034] Step 3: Dry the washed cuttlefish and Bletilla striata with hot air at 80℃-100℃;

[0035] Step 4: Use mechanical ball milling or jet pulverization to pulverize dried cuttlefish and bletilla striata respectively u...

Embodiment 3

[0040] A hemostatic dressing, which comprises cuttlefish made into nano-level powder and cattail yellow made into nanometer powder, wherein the weight component ratio of cuttlefish to cattail yellow is: sea cuttlebone 1-10 parts, cattail 1-10 servings of yellow. The best weight component ratio of sea cuttlebone to cattail yellow is: 1 part sea cuttlebone and 1 part cattail yellow.

[0041] The manufacturing method of the above hemostatic dressing includes the following steps:

[0042] Step one, first wash the cuttlefish and yellowtail, and remove the impurities and soil on the cuttlefish and yellowtail with tap water;

[0043] Step two, wash the cuttlefish and cattail yellow essence, soak and clean the cuttlefish and cattail yellow with deionized water;

[0044] Step 3: Dry the washed sea octopus and typhae with hot air at 80℃-100℃;

[0045] Step 4: Use mechanical ball milling or jet pulverization to pulverize the dried cuttlefish and cattail yellow separately until the diameter of th...

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Abstract

The invention discloses a hemostatic dressing, which comprises cuttlebone made into nanoscale powder and can also comprise bletilla made into nanoscale powder or pollen typhae made into nanoscale powder or pseudo-ginseng made into nanoscale powder. The invention also discloses a production method of the hemostatic dressing, which comprises the following steps of: cleaning cuttlebone with water and then drying the cuttlebone; crushed the dried cuttlebone into nanoscale powder; and sterilizing the cuttlebone made into the nanoscale powder. The hemostatic dressing has the advantages that the time for thrombin generation can be reduced, the activity of plasmin can be inhibited, the contraction of blood vessels can be realized, bleeding can be stopped rapidly and reliably with no blood stasis, traditional Chinese herbal medicine can be modified into nanoscale powder to prepare hemostatic materials with novel functions, and the blood vessels and tissues on bleeding parts can be recovered.

Description

Technical field [0001] The invention relates to a technology in the field of hemostatic dressings, in particular to a hemostatic dressing and a manufacturing method thereof. Background technique [0002] The existing hemostatic dressing generally directly grinds the medicine into a common powder form, and then sprinkles the medicine powder on the bleeding wound, and then bandages the wound. Ordinary powder medicines have large particles, a large number of atoms in the particles, and few atoms on the surface. When ordinary powdered medicine dressings are directly applied to the wound, they will not selectively absorb water molecules in the blood, and will By absorbing other components in the blood, it will cause platelet aggregation and the concentration of clotting factors to increase greatly, and its hemostatic effect is not very ideal. Summary of the invention [0003] Based on this, it is necessary to propose a hemostatic dressing that can quickly stop bleeding and a manufactu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61K35/56A61K36/258A61K36/88A61K36/898A61P7/04A61K35/618
Inventor 许绍衡和光学樊光辉樊伟刘向东邱健张宜李静宜陈冬玲
Owner ZHUHAI HEFAN MEDICINE
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