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Medicine for treating post-chemotherapy leucopenia and preparation method thereof

A technology for leukopenia and drugs, applied in drug combinations, pharmaceutical formulations, extracellular fluid diseases, etc., can solve problems such as poor efficacy, lack of blood sources, and lack of specific drugs for leukopenia, and achieve significant curative effects.

Inactive Publication Date: 2012-07-18
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, colony-stimulating factors are often used as adjuvant therapy for the treatment of leukopenia caused by chemotherapy drugs. These drugs have significant curative effects but are relatively expensive, with short acting time, unstable curative effect, and relatively large side effects. For example, colony-stimulating factors can cause In addition to side effects such as bone pain, flu-like symptoms, fever, and leukopenia after drug withdrawal, it may also stimulate the growth of certain malignant cells, which limits clinical application to a certain extent
In addition, there are other treatments such as hormone therapy, but the disadvantage is that the curative effect is unreliable and it is easy to induce infection; oral administration of vitamins, batyl alcohol, and leucogen has poor curative effect; a small amount of multiple white blood cell transfusion or whole blood transfusion has the disadvantage of high cost, The operation is complicated, and the blood transfusion itself has certain risks. The survival time of the transfused leukocytes in the body is short, and the blood source is currently scarce.
At present, Western medicine lacks specific drugs with good effect on post-chemotherapy leukopenia

Method used

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  • Medicine for treating post-chemotherapy leucopenia and preparation method thereof
  • Medicine for treating post-chemotherapy leucopenia and preparation method thereof
  • Medicine for treating post-chemotherapy leucopenia and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A medicine for treating leukopenia after chemotherapy, which is composed of the following raw materials in proportion by weight: 3 parts of ginseng, 25 parts of astragalus, 15 parts of codonopsis, 20 parts of Atractylodes macrocephala, 15 parts of epimedium, and 15 parts of psoralen , Angelica 12 parts, Caulis Spatholobus 25 parts, Lycium barbarum 25 parts, Ophiopogon japonicus 10 parts, Bupleurum 6 parts, Cimicifuga 6 parts, Pangolin 3 parts.

[0026] Preparation method: Rinse the Chinese medicine decoction pieces of each raw material, then dry, sterilize with ultraviolet rays, pulverize with a pulverizer, and make a powder.

Embodiment 2

[0028] A medicine for treating leukopenia after chemotherapy, which is composed of the following raw materials in proportion by weight: 8 parts of ginseng, 40 parts of astragalus, 30 parts of codonopsis, 30 parts of Atractylodes macrocephala, 30 parts of epimedium, and 20 parts of psoralen , 20 parts of Angelica, 40 parts of Caulis Spatholobus, 35 parts of Lycium barbarum, 20 parts of Ophiopogon japonicus, 20 parts of Bupleurum, 15 parts of Cimicifuga, and 9 parts of pangolin.

[0029] Preparation method: mix the raw materials in proportion according to the stated weight, add about 1000 parts by weight of water, soak for 1 hour, and decoct with an automatic decoction machine to 1 / 3 of the remaining raw water to obtain a water decoction.

Embodiment 3

[0030] Embodiment 3 (most preferred embodiment)

[0031]A medicine for treating leukopenia after chemotherapy, which is composed of the following raw materials in proportion by weight: 5 parts of ginseng, 30 parts of astragalus, 20 parts of codonopsis, 25 parts of Atractylodes macrocephala, 20 parts of epimedium, and 15 parts of psoralen , 15 parts of angelica, 30 parts of Caulis Spatholobus, 30 parts of medlar, 15 parts of Ophiopogon japonicus, 12 parts of Bupleurum, 10 parts of Cimicifuga, and 5 parts of pangolin.

[0032] Preparation method: Rinse the Chinese herbal decoction pieces of each raw material, dry and mix them, then sterilize them with ultraviolet radiation, crush them with a 300-mesh pulverizer, put them into capsules, and then sterilize the capsules with ultraviolet radiation for 30 minutes to obtain capsule preparations (each 0.5g).

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Abstract

The invention discloses a medicine for treating post-chemotherapy leucopenia and a preparation method thereof. The medicine consists of the following raw materials in part by weight: 2 to 20 parts of ginseng, 5 to 50 parts of astragalus, 5 to 50 parts of gensing, 5 to 50 parts of largehead atractylodes rhizome, 5 to 30 parts of epimedium, 5 to 20 parts of malaytea scurfpea fruit, 5 to 30 parts ofChinese angelica, 5 to 50 parts of suberect spatholobus stem, 5 to 50 parts of medlar, 5 to 30 parts of dwarf lilyturf tuber, 3 to 25 parts of bupleurum, 3 to 35 parts of largetrifoliolious bugbane rhizome and 1 to 15 parts of pangolin scales. According to the preparation method, the Chinese medicinal composition is prepared according to a method for the conventional preparation of Chinese medicines, wherein the conventional preparation comprises a water decoction, an oral liquid, granules, capsules or powder and the like. According to the medicine, a prescription for treating post-chemotherapy leucopenia is created on the basis of clinical experiences of multiple years, and a curative effect is obvious.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a medicine for treating malignant tumor patients with leukopenia after chemotherapy by using Chinese herbal medicine as a raw material and a preparation method thereof. Background technique [0002] Chemotherapy is one of the main methods for the treatment of malignant tumors. It can inhibit and kill cancer cells, but it also has a strong killing effect on normal cells and tissues, especially the destruction of bone marrow hematopoietic cells, so that the normal hematopoietic function of bone marrow cannot be restored. , resulting in decreased leukocytes, multiple infections, decreased resistance of patients, and inability to tolerate chemotherapy. Therefore, it is particularly important to protect the hematopoietic function of the bone marrow, increase the number of white blood cells, and reduce the damage of chemotherapy and cancer toxins to the hematopoietic syste...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P7/00A61K35/36
Inventor 赵飞
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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