Water-soluble polymer iron chelator as well as preparation method and application thereof

A technology of water-soluble polymerization and chelating agent, used in drug combination, blood diseases, extracellular fluid diseases, etc.

Inactive Publication Date: 2012-07-25
ZHEJIANG GONGSHANG UNIVERSITY
View PDF6 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports about wate...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-soluble polymer iron chelator as well as preparation method and application thereof
  • Water-soluble polymer iron chelator as well as preparation method and application thereof
  • Water-soluble polymer iron chelator as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, a kind of preparation method of polymer chelating agent (1a), the structural formula of this polymer chelating agent is as follows;

[0033]

[0034] Follow the steps in order:

[0035] 1), the synthesis of the benzyl-protected 3-hydroxypyridin-4-one bidentate ligand (8) containing free amino groups (the synthetic route is as follows):

[0036]

[0037] A. Synthesis of benzyl maltol (4):

[0038] Using maltol (3) as raw material, according to literature method (Y.Ma, W.Luo, P.J.Quinn, Z.Liu, and R.C.Hider, Design, Synthesis, Physicochemical Properties, and Evaluation of Novel Iron Chelators with Fluorescent Sensors, J .Med.Chem.2004, 47, 6349-6362) for synthesis;

[0039] Synthesis of B, 3-benzyloxy-1-(2-benzyloxyethyl)-2-methylpyridin-4(1hydrogen)-one (5):

[0040] Take benzyl maltol (4) (10g, 46.3mmol) and dissolve it in 100ml of ethanol, then add 150ml of distilled water and 2-benzyloxyethylamine (17.5g, 116mol), and heat the resulting mixture at...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a water-soluble polymer iron chelator with a structural general formula shown as the specification, wherein R is alkyl from C1 to C3, (CH2)2-6OH, (CH2)2-6OCH3, (CH2CH2O)1-3H or polyhydroxyl group; R' is H or CH3; n is any one integer selected from 2 to 8; X is O or NH; x ranges from 5 to 200; and y ranges from 50 to 2000. The invention also discloses a preparation method and application of the water-soluble polymer iron chelator. The water-soluble polymer iron chelator can be used for preparing medicaments for treating diseases relevant to overhigh iron content or antibacterial drugs for external use and can also be used for preserving cosmetics or foods.

Description

technical field [0001] The invention relates to a class of water-soluble polymer chelating agent and its preparation method and application. The chelating agent has high affinity and selectivity to ferric iron. Background technique [0002] Polymeric chelating agents have been widely used in water treatment, pollution control, metal recovery and analytical chemistry. Recently, the application of polymeric chelating agents in the biomedical field has also been reported. Iron is an essential element for the life processes of all organisms, yet it can be toxic when present in excess in organisms. Therefore, iron chelators have been used to treat diseases associated with excess iron (such as thalassemia, hemochromatosis and other inherited blood diseases). Targeting iron is an effective method for the treatment of microbial infections, and it also has good prospects in the treatment of malaria, tumors, and neurodegenerative diseases (such as Alzheimer's disease, Parkinson's di...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08F220/28C08F222/38A61P7/06A61P7/00A61P31/04
Inventor 周涛罗伯特·查尔斯·海德徐波
Owner ZHEJIANG GONGSHANG UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap