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Externally applied medicine for treating skin disease and application thereof

A technology for external use of drugs and skin diseases, applied in the field of biomedicine, can solve the problems of prolonged treatment time, drug resistance, strong side effects, etc., and achieve the effects of enhanced therapeutic effect, increased tolerance, and improved compliance

Active Publication Date: 2012-08-01
济南龙华医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although diflorasone, adapalene, and acitretin can be used for the treatment of various inflammatory skin diseases, large doses will have strong side effects on the human body, and long-term repeated use will also produce drug resistance, which will make the treatment of diseases difficult. Prolonged time is not beneficial to patients

Method used

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  • Externally applied medicine for treating skin disease and application thereof
  • Externally applied medicine for treating skin disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Diflurasone 0.05g, adapalene 0.01g, petrolatum 700g, liquid paraffin 149.94g, lanolin 100g, stearic acid 50g.

[0024] Difluraxone and adapalene were crushed separately, dispersed evenly with liquid paraffin, and set aside. Heat and melt vaseline, lanolin, and stearic acid, and when cooled to 40°C-50°C, add diflurasone, adapalene, and liquid paraffin, stir evenly, and cool to obtain the product. Each gram of ointment contains 0.05 mg of diflurasone and 0.01 mg of adapalene.

Embodiment 2

[0026] Diflurasone 0.1g, adapalene 0.5g, petrolatum 700g, liquid paraffin 149.4g, lanolin 100g, stearic acid 50g.

[0027] Difluraxone and adapalene were crushed separately, dispersed evenly with liquid paraffin, and set aside. Heat and melt vaseline, lanolin, and stearic acid, and when cooled to 40°C-50°C, add diflurasone, adapalene, and liquid paraffin, stir evenly, and cool to obtain the product. Each gram of ointment contains 0.1 mg of diflurasone and 0.5 mg of adapalene.

Embodiment 3

[0029] Diflurasone 0.25g, adapalene 2.5g, vaseline 700g, liquid paraffin 98.25g, solid paraffin 10g, lanolin 100g, simethicone 39g, stearic acid 50g.

[0030] Diflorathone and adapalene were crushed separately, dispersed evenly with liquid paraffin and simethicone oil, and set aside. Heat and melt vaseline, solid paraffin, lanolin, and stearic acid, and when cooled to 40°C-50°C, add diflurasone, adapalene, liquid paraffin, and simethicone, stir evenly, and cool, that is have to. Each gram of ointment contains 0.25 mg of diflurasone and 2.5 mg of adapalene.

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Abstract

The invention discloses an externally applied medicine for treating skin disease and application thereof. The medicine consists of an active ingredient and pharmaceutically acceptable auxiliary materials, wherein the active ingredient is a mixture of diflorasone and adapalene, or a mixture of diflorasone and acitretin, or a mixture of diflorasone, adapalene and acitretin. The invention overcomes the defects of poor treatment effect and high side effect of single medication, and the diflorasone and the adapalene or / and the acitretin are compounded to form the compound externally applied medicine. The preparation can be prepared into externally applied formulations in different forms; and due to synergic and complementary effects of medicines, the compound externally applied medicine has high treatment effect, lightens the adverse reaction of the patient in clinical application, has an obvious treatment effect on skin disease, and is easily accepted by the patient.

Description

technical field [0001] The invention relates to a medicine for external use for treating skin diseases and its application, in particular to a compound medicine for external use containing diflorasone and adapalene or / and acitretin and its application, belonging to the technical field of biomedicine. Background technique [0002] Dermatosis is a disease related to the skin, and is one of common diseases and frequently-occurring diseases that have a strong impact on people's health, and it has multiple types. [0003] Allergic skin diseases are skin diseases caused by allergens. Specific allergens can be divided into four categories: contact allergens, inhalation allergens, ingestion allergens, and injection allergens. Eczema is a common inflammatory skin disease of the epidermis and superficial dermis caused by various internal and external factors. Allergic dermatitis is a skin disease caused by allergens. It mainly refers to skin symptoms such as redness, swelling, itchin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/192A61K31/203A61P17/00A61P17/04A61P17/06A61P17/10A61P37/08
Inventor 许东升马全龙王浩骅韩丽丽孙山梁海勇
Owner 济南龙华医药技术有限公司
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