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Sibiraea effective-part extract, preparation method and use thereof

A technology of effective parts and extracts, applied in the field of willow tea effective parts extract and its preparation, can solve the problems of deep color, peculiar smell and high cost

Active Publication Date: 2012-08-22
杭州天诚医药研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current literature reports the pharmacological research of willow tea [Digestion Journal of Integrated Traditional Chinese and Western Medicine, 2009, 17, 376; Chinese Medicinal Materials, 2011, 34, 922; Chinese Medicine New Drugs and Clinical Pharmacology, 2010, 21, 148], there are also some patents [CN1857458; CN102188515; CN101732441; CN101077881] disclosed that some extracts of willow tea can reflect a certain degree of weight loss and lipid-lowering , hair growth, promoting digestion, regulating constipation, etc., but these extracts or refining processes are complex and costly, and the extraction rate is too low, have no actual production value and no clinical verification (CN101077881), or the purity of the active ingredients is not high enough, the color is deep, and the curative effect Not noticeable enough and has a strong odor or some side effects, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of effective part extract of willow tea

[0024]Grind 10 kg of dry willow tea, then extract by heating 100 liters of 1% sodium bicarbonate aqueous solution under reflux for 2 hours, filter the insoluble residue, wash and degrease the obtained water extract with 50 liters of petroleum ether, and then concentrate to Dry, and make 1.3 kilograms of willow tea water extraction paste; 6 kilograms of ethanol heating reflux extracts the above-mentioned pulverized willow tea water extraction paste for 2 hours, obtains 0.54 kilograms of ethanol extracts after the ethanol extract is concentrated to dryness; Analysis, the consumption of adsorbent activated carbon is 1 kilogram, is that 20% ethanol aqueous solution is eluted as eluent with volume concentration, uses silica gel thin-layer chromatography to detect eluent and elution process, and spraying volume concentration is 10% sulfuric acid Methanol solution is used as a chromogen, and 110 o Heating at C fo...

Embodiment 2

[0025] Example 2 Safety inspection of the effective part extract of willow tea

[0026] According to the "Examination Method for Abnormal Toxicity" of the third part of the Chinese Pharmacopoeia in 2010: each drug has 5 healthy mice, and the test product is the effective part extract of willow tea prepared in Example 1, intraperitoneal injection, according to the conventional acute toxicity test Testing was carried out, and the result was normal feeding, and no death was seen within 7 days of observation.

Embodiment 3

[0027] Example 3 Health food with effective part extract of willow tea as effective additive

[0028] The effective part extract of willow tea prepared in Example 1 can be included in foods such as bread, noodles, cakes, biscuits, milk, yogurt and beverages or mineral water in the form of additives, condiments such as soy sauce, oils such as rapeseed oil, sesame oil, tea oil , corn oil and peanut oil, wine such as rice wine, beer, liquor and so on. The dosage of the additive is equivalent to 0.01-10% of the weight of the food.

[0029]

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PUM

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Abstract

The invention relates to a Sibiraea effective-part extract, a preparation method and use of the Sibiraea effective-part extrac. The Sibiraea effective-part extract is prepared by the following preparation method comprising the following steps: hotly extracting the grinded Sibiraea with dilute alkaline water, washing and degreasing the obtained aqueous extract with petroleum ether, concentrating, drying and grinding, then further extracting under a heating and refluxing condition with ethanol; concentrating ethanol solution until the ethanol solution is dry to obtain an ethanol extract, and performing chromatography to the extract with an activated carbon or a silica gel column layer to obtain the Sibiraea effective-part extract. Clinical applications prove that the Sibiraea effective-part extract prepared by the method of the invention is safe and effective, so that the Sibiraea effective-part extract can be used for drugs or health care food for reducing fat, and for health food such as beverage and so on as additives.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine and health products, in particular to an extract of effective parts of willow tea and its preparation method and application. Background technique [0002] The development of obesity technology and the advancement of society have freed human beings from heavy physical labor, and completed daily work and life by operating machines, driving cars, and clicking the mouse. On the other hand, due to the great abundance of material life, high-energy and nutritious foods such as chicken, duck and fish have become common dishes in ordinary people's homes. As a result, eating more and moving less, more and more people suffer from affluence diseases: obesity, which in turn leads to hyperglycemia, hyperlipidemia and high blood pressure, seriously endangering the lives and health of ordinary people. Despite the continuous progress and development of medical methods, three High population depends on...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P3/06A61P3/04A23L1/30
Inventor 林旭锋吴承龙
Owner 杭州天诚医药研究院有限公司
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