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Pharmaceutical composition containing clopidogrel and pharmaceutically acceptable salts thereof and preparation method of pharmaceutical composition

A technology of clopidogrel and composition, which is applied in the field of pharmaceutical composition for the treatment of cardiovascular diseases, and can solve problems such as the lack of research reports on compound preparations of clopidogrel and atorvastatin calcium

Inactive Publication Date: 2012-09-05
北京博时安泰科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the same test conditions, oral administration of ticlopyridine 200mg / kg per day inhibited intimal thickening by 57% (P<0.001); oral aspirin was ineffective
There are no research reports on the compound preparation of clopidogrel and atorvastatin calcium

Method used

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  • Pharmaceutical composition containing clopidogrel and pharmaceutically acceptable salts thereof and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing clopidogrel and pharmaceutically acceptable salts thereof and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription (per 1000 tablets):

[0025] Clopidogrel Bisulfate 97.9g

[0026] Atorvastatin Calcium 21.7g

[0027] Croscarmellose Sodium 15g

[0028] 100g pregelatinized starch

[0029] Microcrystalline Cellulose 50g

[0030] Lactose 20g

[0031] Talc powder 10g

[0032] Macrogol 6000 10g

[0033] The clopidogrel bisulfate and atorvastatin calcium were crushed through an 80-mesh sieve. Fully mix clopidogrel bisulfate, atorvastatin calcium with lactose, pregelatinized starch, microcrystalline cellulose and croscarmellose sodium according to the prescribed amount, and mix them with talcum powder, polyethylene glycol 6000 After mixing evenly, press directly into tablets.

Embodiment 2

[0035] Prescription (per 1000 tablets):

[0036] Clopidogrel Bisulfate 97.9g

[0037] Atorvastatin Calcium 21.7g

[0038] 100g pregelatinized starch

[0039] Low-substituted hydroxypropyl cellulose 20g

[0040] Microcrystalline Cellulose 70g

[0041] Hydrogenated Castor Oil 5g

[0042] The clopidogrel bisulfate and atorvastatin calcium were crushed through an 80-mesh sieve. Fully mix clopidogrel bisulfate, atorvastatin calcium, pregelatinized starch, microcrystalline cellulose and low-substituted hydroxypropyl cellulose according to the prescribed amount, mix with hydrogenated castor oil and directly compress into tablets, that is have to.

Embodiment 3

[0044] Prescription (per 1000 capsules):

[0045] Clopidogrel Bisulfate 97.9g

[0046] Atorvastatin Calcium 21.7g

[0047] Croscarmellose Sodium 15g

[0048] 100g pregelatinized starch

[0049] Microcrystalline Cellulose 50g

[0050] 0.2% ethanol solution of hydroxypropyl methylcellulose appropriate amount

[0051] Stearic acid 10g

[0052] Micronized silica gel 5g

[0053] Pass clopidogrel bisulfate and atorvastatin calcium through an 80-mesh sieve. Mix clopidogrel bisulfate, atorvastatin calcium, microcrystalline cellulose, pregelatinized starch, and cross-linked carmellose sodium according to the prescribed amount, then add an appropriate amount of hydroxypropyl methylcellulose ethanol solution Prepare soft material, granulate, dry, granulate with 18-mesh sieve, fully mix with stearic acid and micropowder silica gel in the prescribed amount, and pack into capsules to obtain.

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Abstract

The invention relates to a compound composition preparation, as well as a preparation method and a use thereof, and particularly relates to a pharmaceutical composition taking clopidogrel and pharmaceutically acceptable salts thereof, as well as atorvastatin calcium as active ingredients, and the preparation method of the pharmaceutical composition. The pharmaceutical composition can be used for preventing and treating cardiovascular and cerebrovascular diseases and performing anti-atherosclerotic and anti-thrombotic treatment, and can further improve the single treatment effect of the clopidogrel and realize the synergy. After the pharmaceutical composition disclosed by the invention is used for preparing a pharmaceutical preparation, the compliance of a patient can be improved.

Description

technical field [0001] The invention belongs to a pharmaceutical composition for treating cardiovascular diseases, in particular to a pharmaceutical composition containing clopidogrel and a pharmaceutically acceptable salt thereof and atorvastatin calcium as active components. Background technique [0002] Cardiovascular and cerebrovascular diseases, including hyperlipidemia, hypertension, arteriosclerosis, cerebral thrombosis, coronary heart disease, myocardial infarction, angina pectoris, etc., are the number one killer of modern human health. Their common pathological basis is atherosclerosis. The three highs in human blood vessels (high blood fat, high triacylglycerol, and high cholesterol) are the main causes of cardiovascular and cerebrovascular diseases, and they have the characteristics of four highs and one high, that is, the onset High rate, high recurrence rate, high disability rate, high fatality rate, and many complications. [0003] Thrombosis in atheroscleros...

Claims

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Application Information

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IPC IPC(8): A61K31/4365A61K31/40A61P9/00A61P9/10A61P7/02
Inventor 颜文革漆新国刘念张俭
Owner 北京博时安泰科技发展有限公司
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