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Application of total extract composite of Luiwei Dijhuang decoction in preparing medicament for treating diabetic nephropathy

A technology of Liuwei Dihuang Decoction and diabetic nephropathy, which is used in drug combinations, urinary system diseases, metabolic diseases, etc.

Inactive Publication Date: 2012-09-05
ZHEJIANG CHINESE MEDICAL UNIV MEDICAL PIECES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent Application No. "200410062502.3" The preparation method of Liuwei Dihuang preparation takes into account the polysaccharide components and fat-soluble ingredients, but this method is only used in the Liuwei Dihuang prescription Some medicines are extracted with alcohol, not as a whole, and some fat-soluble active ingredients are lost

Method used

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  • Application of total extract composite of Luiwei Dijhuang decoction in preparing medicament for treating diabetic nephropathy
  • Application of total extract composite of Luiwei Dijhuang decoction in preparing medicament for treating diabetic nephropathy
  • Application of total extract composite of Luiwei Dijhuang decoction in preparing medicament for treating diabetic nephropathy

Examples

Experimental program
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Embodiment

[0080] Example: Preparation of Liuwei Dihuang Decoction Extract

[0081] Add rehmannia glutinosa, dogwood (made), yam, Alisma, peony cortex and Poria cocos in Liuwei Dihuang Decoction according to the ratio of 8:4:4:3:3:3, add 10 times the amount of water, soak for 3 hours, and decoct twice At the same time, the volatile oil is recovered, each time for 30 minutes, filtered with gauze, concentrated under reduced pressure to a clear ointment, the relative density of the clear ointment is 1.10-1.25 (50°C), and the remaining medicinal residue after filtration is used for later use; the volatile oil is dissolved in absolute ethanol, β -Cyclodextrin is made into a saturated aqueous solution, inject the ethanol solution of volatile oil into the saturated aqueous solution of β-cyclodextrin and keep stirring, then refrigerate (4°C) for 48 hours, filter, add a small amount of petroleum ether (30-60°C) to wash , Dry at 40°C to obtain β-cyclodextrin inclusion compound of volatile oil. Ad...

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Abstract

The invention provides application of a total extract composite of Luiwei Dihuang decoction in preparing a medicament for treating diabetic nephropathy. The total extract composite of Luiwei Dijhuang decoction consists of prepared rehmannia, prepared dogwood, yam, rhizoma alismatis, tree peony bark and poria in a weight ratio of 8:4:4:3:3:3, and is characterized by comprising the volatile oil beta-cyclodextrin inclusion complex components of the total extract of the Luiwei Dijhuang decoction, the polysaccharide components of the total extract of the Luiwei Dijhuang decoction, the glucoside components of the total extract of the Luiwei Dijhuang decoction and the fat-soluble components of the total extract of the Luiwei Dijhuang decoction. According to the application, the defect that the fat-soluble effective components of the total extract of the Luiwei Dijhuang decoction are ignored in the prior art can be overcome, and the more complete component composition of the total extract of the Luiwei Dijhuang decoction can be obtained by the extraction process, and the composite is possible to treat the diabetic nephropathy. Based on the new indication and new target treatment of the Luiwei Dijhuang decoction, the composite can be used for treating the diabetic nephropathy due to inhibition of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase.

Description

technical field [0001] The invention relates to an application of a traditional Chinese medicine composition, in particular to an application of a total extract composition of Liuwei Dihuang Decoction in preparing a medicine for treating diabetic nephropathy. technical background [0002] Liuwei Dihuang Decoction originated from the "Children's Medicine Syndrome Zhijue" written by Qian Yi, a medical scientist in the Song Dynasty. Yin" basic prescription. Its formula has the characteristics of three tonics and three diarrhea: Liuwei Dihuang Decoction reuses rehmannia glutinosa to nourish yin and kidney, replenish essence and marrow, and is the king's medicine. Cornus officinalis nourishes the liver and kidney, and can astringe the essence, which means that the liver and kidney have the same origin. Chinese yam nourishes the spleen and yin, and can also strengthen the kidney. The combination of three medicines, the kidney, liver, spleen and three yin are supplemented togeth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P3/10A61P13/12
Inventor 丛晓东戴德哉张云戴茵王胜波
Owner ZHEJIANG CHINESE MEDICAL UNIV MEDICAL PIECES