The invention relates to a production method of a facial tissue capable of being wetted with water. The production method comprises: respectively adding water to needlebush pulp and hardwood pulp, adjusting the needlebush pulp concentration and the hardwood pulp concentration to 5.0-7.0 wt%, and crushing for 8-15 min; adjusting the needlebush pulp concentration to 4.0-5.0 wt%, and carrying out fiber cutting and fibrillation in a grinder; adding water to adjust the hardwood pulp concentration to 4.0-5.0 wt%, and carrying out fiber defibrating in a defibrating machine; mixing 50-60% of the needlebush pulp and 50-40% of the hardwood pulp, adjusting the concentration to 3.0-4.0 wt%, and carrying out further cutting and fibrillation through the grinder; adding a wet strength agent and a softener to the mixed pulp, and adjusting the concentration to 2.9-3.1 wt%; and diluting the obtained mixed pulp to 0.2-0.25 wt% by using a pulp beating pump, feeding into a papermaking machine, molding, squeezing, and drying to finally prepare the product. According to the present invention, when the prepared facial tissue used for water wiping and sweat wiping, the facial tissue is not broken, and no residue paper exists; the prepared facial tissue can be used as the wet wipe and the face washing towel after the prepared facial tissue is wetted with the water; and the hand feeling and the smoothness of the facial tissue are improved, such that the use is comfortable.