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Transdermally-absorbed medicament used for skin and consisting of adjuvant-containing fluticasone propionate and adjuvant-containing water

A technology of fluticasone propionate and pharmaceutical excipients, which can be applied to medical preparations containing active ingredients, skin diseases, drug combinations, etc., and can solve the problems of unstable particles and the inability to guarantee the Ostwald ripening of particle suspensions, etc. , to achieve the effect of reducing waste and ensuring the stability of the suspension

Inactive Publication Date: 2012-09-12
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems to be solved in pharmacy, but no matter whether by adding excipients or improving the particle structure, there is no guarantee that microparticle suspensions will not appear Osmos during storage. Twald ripening, especially with multiple uses of dermal suspensions, is more likely to occur

Method used

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  • Transdermally-absorbed medicament used for skin and consisting of adjuvant-containing fluticasone propionate and adjuvant-containing water
  • Transdermally-absorbed medicament used for skin and consisting of adjuvant-containing fluticasone propionate and adjuvant-containing water
  • Transdermally-absorbed medicament used for skin and consisting of adjuvant-containing fluticasone propionate and adjuvant-containing water

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preparation example Construction

[0039] 1. Preparation of drug particles for transdermal absorption

[0040] The capsules packed with the drug microparticles obtained in Examples 1 to 10 are plant capsules, and the capsules are sealed and packaged with aluminum foil blisters after packing. The water containing auxiliary materials obtained in Examples 11 and 12 is sealed and packed in ampoules.

Embodiment 1

[0042] Dissolve 0.2g fluticasone propionate in ethanol, filter, sterilize, spray-dry the filtrate, micronize the particle size to 3μm, mix with 1.5g crystalline lactose with a particle size of 30μm, pass through a 200-mesh sieve for 3 times and mix well Finally, it is divided into No. 2 capsules, and each capsule has 2 mg of fluticasone propionate. Electron microscope observation shows that the drug particles are spherical.

[0043] The process conditions are: the inlet temperature is 100°C, the outlet temperature is 70°C, the air flow rate is 90%, the inner diameter of the nozzle outlet is 0.1cm, the air flow rate of the nozzle is 800ml / min, and the injection speed is 50mL / h

Embodiment 2

[0045] Dissolve 1 g of fluticasone propionate in ethanol, filter, spray-dry the filtrate, micronize the particle size to 3 μm, mix it with 15 g of crystalline lactose with a particle size of 30 μm, mix it with a 200-mesh sieve for 3 times, and then sterilize it. Packed into No. 2 capsules, each capsule contains 1 mg of fluticasone propionate. Electron microscope observation shows that the particles are spherical.

[0046] The process conditions are as follows: inlet temperature is 105°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, and sample injection speed is 50mL / h.

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Abstract

A transdermally-absorbed medicament used for skin and consisting of adjuvant-containing fluticasone propionate and adjuvant-containing water comprises: fluticasone propionate which is single packaged and water-insoluable, has a D90 particle size of 0.1 to 10 [mu]m, and contains one or a plurality of solid pharmaceutic adjuvants; and water which is single packaged and contains one or a plurality of water-soluable pharmaceutic adjuvants.

Description

Technical field: [0001] The invention relates to a medicine for skin, which is composed of separately packaged fluticasone propionate which contains one or several auxiliary materials for skin medicine and hardly soluble in water, and water containing the auxiliary materials which are individually packaged. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by allergic reactions caused by certain allergens. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs are not easy to pass through the effective and selective barrier of human skin. Drugs with higher solubility cross the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal drug delivery system or transdermal drug delivery s...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K9/10A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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