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Polymersome and process for producing same

A polymer and vesicle technology, applied in microcapsule preparations, chemical instruments and methods, drug combinations, etc., can solve the problems of unoptimized skin safety, insufficient stability of vesicles over time, etc. The effect of good feeling in use and excellent matrix stability

Active Publication Date: 2012-09-12
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the technology of Patent Document 2 related to hair cosmetics may be unfavorable for skin safety due to the amount of cationic surfactant blended.
Furthermore, in the technology of Patent Document 3, vesicles can be obtained by a simple method using an amino acid-based surfactant, but the stability of the vesicles over time is insufficient

Method used

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  • Polymersome and process for producing same
  • Polymersome and process for producing same
  • Polymersome and process for producing same

Examples

Experimental program
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preparation example Construction

[0062] Next, a method for producing the polymersome of the present invention will be described.

[0063] The polymer vesicles involved in the present invention can be obtained by thoroughly mixing the above-mentioned block-type oxyalkylene derivatives with a specific structure and water-soluble alcohol, and then adding the mixed solution dropwise to an aqueous solvent while stirring to form a polymer vesicle assembly. material for preparation.

[0064] In the preparation method of the present invention, the blending amount of the block-type oxyalkylene derivative is 0.1-20% by mass, more preferably 0.1-10% by mass, relative to the finally produced polymer vesicle composition. When the blending amount of the block-type oxyalkylene derivative is less than 0.1% by mass, the effect by blending may not be sufficiently expressed, and if it exceeds 20% by mass, a sticky feeling may be produced. Moreover, it is preferable to set the compounding quantity of a water-soluble alcohol so ...

Embodiment

[0115] Next, examples will be given to describe the present invention more specifically. The present invention is not limited by them. In addition, unless otherwise specified, all compounding amounts are expressed in mass %.

[0116] First, the evaluation methods used in the respective examples and comparative examples will be described.

[0117] Evaluation (1): Polymer Vesicle Formation Ability

[0118] In each of the obtained samples, whether or not polymer vesicles (vesicle structures) were formed was determined by the following method. Judgment criteria are as follows.

[0119] ○: Particles with a size of 50 to 500 nm were confirmed by dynamic light scattering measurement, and inclusion of a water-soluble dye was confirmed by absorbance measurement (*). In addition, turbidity, precipitation, etc. were not found at all.

[0120] ×: Vesicle particles of 50 to 500 nm were not confirmed by dynamic light scattering measurement. Or even if it is found, turbidity and precip...

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Abstract

Provided is a polymersome composition that has skin disorder remedying effects, that is safe, that provides a pleasant feel upon use and a fresh feel without any stickiness, and that has excellent base-agent stability. The disclosed polymersome contains, as a membrane component, a block-type alkylene oxide derivative represented by the following formula (I): R1O-[(EO)l(AO)m(EO)n]-R2. (In the formula, AO represents an oxyalkylene group having 3 or 4 carbons; EO represents an oxyethylene group; m represents an average addition mole number of the oxyalkylene group and satisfies 1=m=70; and l+n represents an average addition mole number of the oxyethylene group and satisfies 1=l+n=70. The percentage of the oxyethylene group to the sum of the oxyalkylene group having 3 or 4 carbons and the oxyethylene group is 20% to 80% by mass. The oxyalkylene group having 3 or 4 carbons and the oxyethylene group are added blockwise. R1 and R2 each represent a hydrocarbon group having 1 to 4 carbons, which may be the same or different from each other.)

Description

[0001] related application [0002] This application claims the priority of Japanese Patent Application No. 2009-272001 for which it applied on November 30, 2009, and takes in the content here. technical field [0003] The invention relates to a polymer vesicle and a preparation method, in particular to the improvement of its matrix stability, skin irritation and use feeling. Background technique [0004] If the drug is microencapsulated and administered into the living body, the metabolism of the drug in the living body is inhibited, and the drug effect can be maintained for a long time. Various techniques of encapsulation. As one of them, so-called vesicles are attracting attention. Vesicles are closed vesicles with a bimolecular membrane structure formed by amphiphilic substances. Due to their specific structure, they can contain active ingredients and have attracted attention as carriers for drug delivery systems. [0005] Many studies have been conducted on amphiphil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/90A61K8/14A61K8/34A61K8/37A61K9/127A61K47/34A61Q19/00B01J13/00B01J13/04
CPCA61K8/86A61K9/1273A61K2800/75A61Q19/00B01J13/02Y10S977/773A61P17/00A61K8/11A61K8/14A61K9/14C08G18/4833C08G18/4837C08G18/4854
Inventor 杉山由纪大森隆司古贺信义
Owner SHISEIDO CO LTD
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