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Ropinirole hydrochloride osmotic pump type controlled release tablet

A technology of ropinirole hydrochloride and osmotic pump, which is applied in the directions of non-active ingredients medical preparations, pill delivery, organic active ingredients, etc., can solve the problems of decreased release performance, aging, etc.

Inactive Publication Date: 2012-09-19
内蒙古天衡医院管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Osmotic pump-type controlled-release tablets made of currently commonly used semi-permeable membrane materials, such as cellulose acetate + polyethylene glycol, ethyl cellulose + polyethylene glycol, have good release performance within a period of time just after preparation , but after storage for a period of time, its release performance begins to decline, the longer the storage time, the more obvious the decline, often in the second half of the drug's specified validity period, the release performance declines significantly, the popular saying is aging

Method used

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  • Ropinirole hydrochloride osmotic pump type controlled release tablet
  • Ropinirole hydrochloride osmotic pump type controlled release tablet
  • Ropinirole hydrochloride osmotic pump type controlled release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] 1. Prescription

[0068] 1. Tablet core prescription (based on 1000 tablets, specification: 6mg, based on ropinirole):

[0069] Drug-containing layer:

[0070]

[0071] Boost layer:

[0072]

[0073]

[0074] 2. Prescription of semi-permeable membrane coating solution

[0075]

[0076] 3. Prescription of film coating solution

[0077] composition

Dosage

Gastric type coating powder

10g

water

100ml

[0078] 2. Detailed preparation process

[0079] 1. Preparation process of ropinirole hydrochloride tablet core:

[0080] The tablet core is a double-layer tablet, one layer is a drug-containing layer, and the other layer is a booster layer.

[0081] The preparation process is as follows:

[0082] Drug-containing layer:

[0083] (1) ropinirole hydrochloride is passed through a 100-mesh sieve, sodium lauryl sulfate is crushed through a 100-mesh sieve, and sucrose is crushed through a 80-mesh sieve;

[0084] (2) r...

Embodiment 2

[0121] 1. Prescription

[0122] 1. Tablet core prescription: same as Example 1

[0123] 2. Prescription of semi-permeable membrane coating solution:

[0124]

[0125] 3. Prescription of film coating solution: same as Example 1

[0126] 2. Detailed preparation process

[0127] 1. Preparation process of ropinirole hydrochloride tablet core:

[0128] Same as Example 1

[0129] 2. Preparation process of semi-permeable membrane coating solution

[0130] Weigh the prescribed amount of povidone K30 and ethyl cellulose (N-100), add to ethanol and stir to dissolve completely, to obtain.

[0131] 3. Semi-permeable membrane coating: put the tablet core in a multi-functional coating machine for coating, take a small amount of tablets regularly and weigh them, and calculate the weight gain of the coating. The coating weight gain was 12.0% and 14.0%, respectively.

[0132] 4, heat treatment: with embodiment 1

[0133] 5. Laser drilling: same as Example 1

[0134] 6. Preparation ...

Embodiment 3

[0149] 1. Prescription

[0150] 1. Tablet core prescription: same as Example 1

[0151] 2. Prescription of semi-permeable membrane coating solution

[0152]

[0153] 3. Prescription of film coating solution: same as Example 1

[0154] 2. Detailed preparation process

[0155] 1. Preparation process of ropinirole hydrochloride tablet core: same as Example 1

[0156] 2. Preparation process of semi-permeable membrane coating solution

[0157] Weigh the prescribed amount of povidone K30 and ethyl cellulose (N-100), add to ethanol and stir to dissolve completely, to obtain.

[0158] 3. Semi-permeable membrane coating: put the tablet core in a multi-functional coating machine for coating, take a small amount of tablets regularly and weigh them, and calculate the weight gain of the coating. Coating weight gain was 15.0%, 18.0%, respectively.

[0159] 4, heat treatment: with embodiment 1.

[0160] 5. Laser drilling: same as embodiment 1.

[0161] 6. Preparation process of fi...

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Abstract

The invention provides a ropinirole hydrochloride osmotic pump type controlled release tablet, which adopts ethyl cellulose and polyvinylpyrrolidone as semipermeable membrane formation materials, an asymmetric tablet type is preferable, the ageing phenomenon of the semipermeable membrane can be overcome, and the medicine residue is lowered. The invention also provides a method for improving the anti-ageing performance of the ropinirole hydrochloride osmotic pump type controlled release tablet. The method is characterized in that the ethyl cellulose-polyvinylpyrrolidone is adopted to serve as the semipermeable membrane material. In addition, the invention also provides an application of the ethyl cellulose-polyvinylpyrrolidone composite to prepare the ropinirole hydrochloride osmotic pump type controlled release tablet with the anti-ageing performance.

Description

technical field [0001] The invention relates to a ropinirole hydrochloride osmotic pump-type controlled-release tablet, which uses ethyl cellulose-povidone as a semipermeable membrane material and belongs to the field of pharmaceutical preparations. Background technique [0002] Ropinirole hydrochloride is a dopamine receptor agonist used to treat Parkinson's disease. [0003] This product was first marketed as a common preparation that was taken 3 times a day. Due to the difficulty in taking the medicine, the patient's compliance was poor. In addition, continuous stimulation of dopamine receptors for long-term relief of symptoms is a basic requirement for the treatment of Parkinson's disease. Therefore, a common sustained-release preparation that is taken once a day has been launched abroad. [0004] Since the ropinirole hydrochloride sustained-release preparation is a non-constant release drug, the release and absorption rate of the drug is also affected by factors such ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K9/36A61K31/4045A61K47/38A61P25/16
Inventor 姜庆伟刘全志狄媛吕玉珠唐亚坤杨敏衣伟锋梁希葛振中王丽红姜静
Owner 内蒙古天衡医院管理有限公司