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Application of 6-benzyl aminopurine compound in terms of preparation of composition for suppressing oxidative injury to brain tissues

A technology for benzylaminopurine and oxidative damage, which is applied in the direction of drug combination, active ingredient of heterocyclic compounds, application, etc., and can solve the problems of difficult extraction and acquisition, high price, troublesome application, etc.

Inactive Publication Date: 2013-12-25
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are many substances that resist oxidative damage to brain tissue on the market, but most of them have disadvantages such as difficult extraction, low purity, unclear active ingredients, and high price, which brings great trouble to the application.

Method used

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  • Application of 6-benzyl aminopurine compound in terms of preparation of composition for suppressing oxidative injury to brain tissues
  • Application of 6-benzyl aminopurine compound in terms of preparation of composition for suppressing oxidative injury to brain tissues
  • Application of 6-benzyl aminopurine compound in terms of preparation of composition for suppressing oxidative injury to brain tissues

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Embodiment

[0020] The role of 6-benzylaminopurine in improving the ability of brain tissue to resist oxidative damage was tested by experimental animals and injury models. D-galactose (D-gal) is a commonly used oxygen free radical inducer. Oxygen free radicals will be generated to construct the oxidative damage environment of brain tissue in mice, and its effect on inhibiting oxidative damage of brain tissue was tested by ingesting 6-benzylaminopurine. This example is only used to illustrate rather than limit the application of the present invention, and it will have the same effect on brain tissue oxidative damage caused by other free radical inducers or natural factors.

[0021] 1. Test drugs and reagents: 6-BA, purchased from Xiamen Xinglongda Chemical Reagent Co., Ltd., produced by Sanland Company in the United States, and prepared into 1000mg / L and 2000mg / L stock solutions with 0.06mol / L hydrochloric acid; Aldehyde (MDA) detection kit, glutathione peroxidase (GSH-Px) detection kit, ...

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Abstract

The invention discloses application of a 6-benzyl aminopurine compound in terms of preparation of a composition for suppressing oxidative injury to brain tissues. Large quantities of experiments prove that 6-BA (benzyl aminopurine) also has an oxidative injury resistant effect for brain tissues of animals. The 6-benzyl aminopurine compound can be used as an active substance for resisting oxidative injury to the brain tissues, and is added into medicines, food or healthcare products to suppress oxidative injury to the brain tissues, delay ageing and resist fatigue, and oxidative injury resistance of the brain tissues is strengthened. Medicines comprising the 6-benzyl aminopurine compound can be made into any pharmaceutically acceptable dosage form, and the dosage of the medicines is about 900mg / kgbw.

Description

technical field [0001] The invention relates to the application of a compound 6-benzylaminopurine for preparing a composition for inhibiting oxidative damage of brain tissue. Background technique [0002] The accumulation of oxidative damage is the main cause of aging and disease. The toxicity of oxygen is not due to the reactivity of the oxygen molecule itself, but is due to many intermediate products produced during the reduction of the oxygen molecule to water, including superoxide anion, hydrogen peroxide molecule, hydroxyl radical, hydroperoxyl, hydroperoxide, etc. Oxides, alkoxy, alkoperoxy and singlet oxygen, these intermediates are customarily called free radicals. Since free radicals are atoms, molecules or ions with unpaired electrons, which tend to gain or lose electrons, they are particularly active and highly reactive, and can easily react with other substances to generate new free radicals or oxidation thing. In the process of organism's life activities, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/52A61P25/00A23L1/30
Inventor 刘玉梅张自强邓雯吕琼霞陈晓光
Owner HENAN UNIV OF SCI & TECH
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